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Strain Name:
C57BL/6J-MtgxR9278Btlr/Mmmh
Stock Number:
069097-MU
Citation ID:
RRID:MMRRC_069097-MU
Other Names:
R9278 (G1)
Major Collection:

Strain Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Col1a-1, Mov-13, Cola1, Cola-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, C230047C07Rik, 8030492O04Rik, AIP4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16396
Homologene: 88442
Slc2a1
Name: solute carrier family 2 (facilitated glucose transporter), member 1
Synonyms: Glut-1, Glut1, M100200, Rgsc200
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20525
Homologene: 68520
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106585
Homologene: 9059
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to A, chromosome 1 at 74,236,882 bp (GRCm38)
  • C to A, chromosome 1 at 135,973,447 bp (GRCm38)
  • T to C, chromosome 1 at 152,383,347 bp (GRCm38)
  • A to C, chromosome 2 at 18,699,174 bp (GRCm38)
  • T to C, chromosome 2 at 40,597,064 bp (GRCm38)
  • C to T, chromosome 2 at 52,256,178 bp (GRCm38)
  • T to C, chromosome 2 at 75,977,031 bp (GRCm38)
  • G to T, chromosome 2 at 84,678,631 bp (GRCm38)
  • A to C, chromosome 2 at 89,609,604 bp (GRCm38)
  • C to T, chromosome 2 at 126,164,808 bp (GRCm38)
  • A to G, chromosome 2 at 155,203,297 bp (GRCm38)
  • T to C, chromosome 2 at 165,360,090 bp (GRCm38)
  • A to T, chromosome 3 at 32,454,438 bp (GRCm38)
  • A to G, chromosome 3 at 38,891,022 bp (GRCm38)
  • A to T, chromosome 4 at 119,133,410 bp (GRCm38)
  • A to G, chromosome 4 at 134,195,459 bp (GRCm38)
  • T to A, chromosome 4 at 149,995,850 bp (GRCm38)
  • T to C, chromosome 5 at 38,302,815 bp (GRCm38)
  • A to G, chromosome 5 at 77,323,638 bp (GRCm38)
  • A to G, chromosome 6 at 24,876,695 bp (GRCm38)
  • C to A, chromosome 6 at 56,780,346 bp (GRCm38)
  • C to T, chromosome 6 at 122,561,895 bp (GRCm38)
  • T to A, chromosome 6 at 123,204,265 bp (GRCm38)
  • T to C, chromosome 6 at 123,274,690 bp (GRCm38)
  • G to T, chromosome 6 at 123,274,692 bp (GRCm38)
  • G to T, chromosome 7 at 45,231,352 bp (GRCm38)
  • A to G, chromosome 7 at 46,790,973 bp (GRCm38)
  • T to A, chromosome 7 at 85,620,580 bp (GRCm38)
  • A to T, chromosome 7 at 107,197,842 bp (GRCm38)
  • T to C, chromosome 7 at 114,028,953 bp (GRCm38)
  • T to A, chromosome 7 at 118,434,257 bp (GRCm38)
  • T to C, chromosome 7 at 140,611,023 bp (GRCm38)
  • A to G, chromosome 8 at 57,512,752 bp (GRCm38)
  • A to T, chromosome 8 at 61,977,978 bp (GRCm38)
  • A to T, chromosome 8 at 71,474,486 bp (GRCm38)
  • A to T, chromosome 8 at 75,057,255 bp (GRCm38)
  • A to G, chromosome 8 at 94,511,280 bp (GRCm38)
  • C to T, chromosome 9 at 21,505,681 bp (GRCm38)
  • A to G, chromosome 9 at 39,289,485 bp (GRCm38)
  • C to T, chromosome 9 at 42,046,561 bp (GRCm38)
  • G to T, chromosome 9 at 44,135,176 bp (GRCm38)
  • C to T, chromosome 10 at 40,007,334 bp (GRCm38)
  • T to A, chromosome 10 at 74,991,605 bp (GRCm38)
  • T to C, chromosome 10 at 80,325,390 bp (GRCm38)
  • A to G, chromosome 10 at 123,171,207 bp (GRCm38)
  • T to C, chromosome 11 at 73,324,454 bp (GRCm38)
  • T to A, chromosome 11 at 94,947,277 bp (GRCm38)
  • G to A, chromosome 11 at 98,372,105 bp (GRCm38)
  • T to C, chromosome 11 at 119,435,942 bp (GRCm38)
  • A to T, chromosome 12 at 26,469,569 bp (GRCm38)
  • A to T, chromosome 12 at 70,994,382 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • T to C, chromosome 13 at 11,883,090 bp (GRCm38)
  • A to T, chromosome 13 at 23,184,088 bp (GRCm38)
  • A to G, chromosome 13 at 56,463,739 bp (GRCm38)
  • A to G, chromosome 13 at 95,976,081 bp (GRCm38)
  • G to A, chromosome 14 at 52,235,170 bp (GRCm38)
  • A to G, chromosome 14 at 79,462,046 bp (GRCm38)
  • C to T, chromosome 14 at 118,874,235 bp (GRCm38)
  • A to G, chromosome 15 at 9,727,409 bp (GRCm38)
  • A to G, chromosome 15 at 73,586,357 bp (GRCm38)
  • A to G, chromosome 15 at 76,636,771 bp (GRCm38)
  • A to G, chromosome 15 at 83,892,893 bp (GRCm38)
  • G to A, chromosome 16 at 15,816,659 bp (GRCm38)
  • T to G, chromosome 16 at 36,969,578 bp (GRCm38)
  • C to A, chromosome 16 at 45,825,945 bp (GRCm38)
  • T to A, chromosome 16 at 91,505,125 bp (GRCm38)
  • C to A, chromosome 17 at 12,695,353 bp (GRCm38)
  • T to A, chromosome 17 at 13,804,008 bp (GRCm38)
  • A to G, chromosome 17 at 17,402,949 bp (GRCm38)
  • A to T, chromosome 17 at 18,914,500 bp (GRCm38)
  • A to T, chromosome 17 at 20,472,299 bp (GRCm38)
  • A to T, chromosome 17 at 37,924,384 bp (GRCm38)
  • A to T, chromosome 17 at 38,130,802 bp (GRCm38)
  • C to T, chromosome 17 at 66,037,604 bp (GRCm38)
  • A to G, chromosome 18 at 37,308,872 bp (GRCm38)
  • T to C, chromosome 18 at 45,592,379 bp (GRCm38)
  • A to G, chromosome 18 at 69,633,581 bp (GRCm38)
  • C to T, chromosome 19 at 17,123,780 bp (GRCm38)
  • C to T, chromosome 19 at 39,609,255 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9278 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069097-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.