Strain Name:
C57BL/6J-MtgxR9280Btlr/Mmmh
Stock Number:
069099-MU
Citation ID:
RRID:MMRRC_069099-MU
Other Names:
R9280 (G1)
Major Collection:

Strain Information

Apobec3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms: Rfv-3, CEM15, Rfv3, Gm20117
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 80287
Homologene: 105420
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Tbc1d14
Name: TBC1 domain family, member 14
Synonyms: 2810413P16Rik, D5Ertd110e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100855
Homologene: 10809
Ilf2
Name: interleukin enhancer binding factor 2
Synonyms: TEG-267, 6230405A16Rik, Tex261, Tex267
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67781
HGNC: HGNC:6037
Homologene: 26894
Mmp27
Name: matrix metallopeptidase 27
Synonyms: LOC234911
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234911
Homologene: 23345
Glul
Name: glutamate-ammonia ligase
Synonyms: Glns, GS
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14645
HGNC: HGNC:4341
Homologene: 37567
Rasa1
Name: RAS p21 protein activator 1
Synonyms: p120-rasGAP, Gap
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Eif2a
Name: eukaryotic translation initiation factor 2A
Synonyms: D3Ertd194e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229317
HGNC: HGNC:3254
Homologene: 5969
Slc25a36
Name: solute carrier family 25, member 36
Synonyms: C330005L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 192287
Homologene: 10039
Usp8
Name: ubiquitin specific peptidase 8
Synonyms: Ubpy
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 84092
Homologene: 3782
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: 4932415L06Rik, C330008N13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319651
Homologene: 10858
Rag2
Name: recombination activating gene 2
Synonyms: Rag-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19374
HGNC: HGNC:9832
Homologene: 7507
Kbtbd2
Name: kelch repeat and BTB (POZ) domain containing 2
Synonyms: Bklhd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 210973
Homologene: 17122
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Crppa
Name: CDP-L-ribitol pyrophosphorylase A
Synonyms: 4930579E17Rik, Ispd
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75847
VEGA: 12
Homologene: 45614
Grb7
Name: growth factor receptor bound protein 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14786
HGNC: HGNC:4567
Homologene: 3881
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: aldosterone receptor, Mlr, MR, mineralocorticoid receptor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232854
Homologene: 119890
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320495
Homologene: 32271
Slco1a8
Name: solute carrier organic anion transporter family, member 1a8
Synonyms: Gm6614
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 625716
Homologene: 87075
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209590
Homologene: 16930
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
F830045P16Rik
Name: RIKEN cDNA F830045P16 gene
Synonyms: Sirpb3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228592
Homologene: 136180
Slc39a12
Name: solute carrier family 39 (zinc transporter), member 12
Synonyms: LOC277468
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277468
Homologene: 17654
Acrbp
Name: proacrosin binding protein
Synonyms: sp32, OY-TES-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54137
Homologene: 9641
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55963
Homologene: 20655
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Pappa2
Name: pappalysin 2
Synonyms: placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20649
Homologene: 9618
Mpeg1
Name: macrophage expressed gene 1
Synonyms: Mpg-1, MPS1, Perforin-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17476
VEGA: 19
Homologene: 11216
Ctbs
Name: chitobiase
Synonyms: 2210401K11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74245
HGNC: HGNC:2496
Homologene: 3231
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: 4930415K13Rik, Rgsl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16565
Homologene: 56868
Pcdhb15
Name: protocadherin beta 15
Synonyms: Pcdhb7, PcdhbO
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Mterf1a
Name: mitochondrial transcription termination factor 1a
Synonyms: 9230106K09Rik, 4931431L11Rik, Mterf1, Mterf
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545725
Homologene: 5073
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: LOC382077, 4930535E21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382077
Homologene: 19641
Or5d14
Name: olfactory receptor family 5 subfamily D member 14
Synonyms: GA_x6K02T2Q125-49542541-49541597, MOR174-14, Olfr1162
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258105
Homologene: 79476
Nup50l
Name: nucleoporin 50 like
Synonyms: 1700123L14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78482
HGNC: HGNC:8065
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Aoc1l1
Name: amine oxidase copper containing 1-like 1
Synonyms: Doxl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243376
HGNC: HGNC:80
Homologene: 19443
Mmp8
Name: matrix metallopeptidase 8
Synonyms: Collagenase-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17394
VEGA: 9
HGNC: HGNC:7175
Homologene: 22482
Trappc13
Name: trafficking protein particle complex 13
Synonyms: 2610524F24Rik, 2410002O22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66975
Homologene: 11792
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: 2810457I06Rik, TULA-2, Sts-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72828
Homologene: 13152
Zfp72
Name: zinc finger protein 72
Synonyms: Zfp74
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238722
VEGA: 13
Homologene: 108290
Or7e173
Name: olfactory receptor family 7 subfamily E member 173
Synonyms: GA_x6K02T2PVTD-13768406-13767468, MOR145-5, Olfr866
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258551
HGNC: HGNC:8396
Homologene: 133687
Or5g25
Name: olfactory receptor family 5 subfamily G member 25
Synonyms: GA_x6K02T2Q125-47127746-47126790, MOR175-2, Olfr1002
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258566
Homologene: 104131
Entpd2
Name: ectonucleoside triphosphate diphosphohydrolase 2
Synonyms: NTPDase2, Cd39l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12496
HGNC: HGNC:3364
Homologene: 20333
Fam76b
Name: family with sequence similarity 76, member B
Synonyms: 2810485I05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72826
Homologene: 25107
Pcdhgb7
Name: protocadherin gamma subfamily B, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93704
HGNC: HGNC:8714
Homologene: 75102
Ighv6-3
Name: immunoglobulin heavy variable 6-3
Synonyms: Gm16930
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629845
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Trbj1-1
Name: T cell receptor beta joining 1-1
Synonyms: Gm16646
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100125248
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 74,450,540 bp (GRCm38)
  • T to C, chromosome 1 at 136,171,707 bp (GRCm38)
  • A to T, chromosome 1 at 153,794,152 bp (GRCm38)
  • T to C, chromosome 1 at 153,907,865 bp (GRCm38)
  • G to A, chromosome 1 at 158,847,963 bp (GRCm38)
  • A to T, chromosome 2 at 14,396,192 bp (GRCm38)
  • A to G, chromosome 2 at 25,399,499 bp (GRCm38)
  • G to A, chromosome 2 at 85,648,160 bp (GRCm38)
  • A to T, chromosome 2 at 88,050,114 bp (GRCm38)
  • A to T, chromosome 2 at 101,629,800 bp (GRCm38)
  • T to C, chromosome 2 at 117,282,651 bp (GRCm38)
  • G to C, chromosome 2 at 126,720,024 bp (GRCm38)
  • G to A, chromosome 2 at 129,472,854 bp (GRCm38)
  • T to C, chromosome 3 at 33,816,004 bp (GRCm38)
  • A to G, chromosome 3 at 58,539,588 bp (GRCm38)
  • A to G, chromosome 3 at 83,281,948 bp (GRCm38)
  • A to G, chromosome 3 at 90,487,615 bp (GRCm38)
  • A to T, chromosome 3 at 146,454,387 bp (GRCm38)
  • A to T, chromosome 5 at 3,891,539 bp (GRCm38)
  • A to G, chromosome 5 at 30,371,550 bp (GRCm38)
  • T to C, chromosome 5 at 36,522,924 bp (GRCm38)
  • C to T, chromosome 5 at 139,764,714 bp (GRCm38)
  • C to T, chromosome 5 at 146,525,946 bp (GRCm38)
  • A to G, chromosome 6 at 41,533,896 bp (GRCm38)
  • A to G, chromosome 6 at 48,978,182 bp (GRCm38)
  • A to T, chromosome 6 at 56,137,520 bp (GRCm38)
  • G to A, chromosome 6 at 56,779,012 bp (GRCm38)
  • A to G, chromosome 6 at 67,452,426 bp (GRCm38)
  • A to C, chromosome 6 at 96,165,001 bp (GRCm38)
  • G to T, chromosome 6 at 125,062,975 bp (GRCm38)
  • A to G, chromosome 6 at 141,994,252 bp (GRCm38)
  • A to G, chromosome 7 at 7,181,409 bp (GRCm38)
  • G to A, chromosome 7 at 29,102,964 bp (GRCm38)
  • T to A, chromosome 8 at 76,909,344 bp (GRCm38)
  • A to T, chromosome 8 at 95,770,599 bp (GRCm38)
  • A to G, chromosome 9 at 7,567,291 bp (GRCm38)
  • A to T, chromosome 9 at 7,579,811 bp (GRCm38)
  • A to T, chromosome 9 at 13,839,716 bp (GRCm38)
  • A to C, chromosome 9 at 20,027,343 bp (GRCm38)
  • A to C, chromosome 9 at 41,161,581 bp (GRCm38)
  • A to T, chromosome 9 at 58,058,266 bp (GRCm38)
  • A to C, chromosome 9 at 97,100,180 bp (GRCm38)
  • A to G, chromosome 9 at 107,931,374 bp (GRCm38)
  • T to C, chromosome 10 at 6,900,736 bp (GRCm38)
  • A to T, chromosome 10 at 69,982,191 bp (GRCm38)
  • A to G, chromosome 11 at 20,332,325 bp (GRCm38)
  • G to A, chromosome 11 at 55,310,697 bp (GRCm38)
  • G to A, chromosome 11 at 67,255,309 bp (GRCm38)
  • T to C, chromosome 11 at 98,454,422 bp (GRCm38)
  • T to A, chromosome 12 at 36,521,976 bp (GRCm38)
  • A to G, chromosome 12 at 65,106,838 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • T to A, chromosome 12 at 114,391,800 bp (GRCm38)
  • T to C, chromosome 13 at 74,372,684 bp (GRCm38)
  • C to T, chromosome 13 at 85,288,613 bp (GRCm38)
  • C to T, chromosome 13 at 104,154,301 bp (GRCm38)
  • T to C, chromosome 15 at 55,906,375 bp (GRCm38)
  • A to G, chromosome 15 at 79,313,114 bp (GRCm38)
  • A to C, chromosome 15 at 79,906,881 bp (GRCm38)
  • A to T, chromosome 17 at 30,785,097 bp (GRCm38)
  • A to G, chromosome 18 at 37,474,741 bp (GRCm38)
  • T to C, chromosome 18 at 37,753,532 bp (GRCm38)
  • A to G, chromosome 19 at 12,462,464 bp (GRCm38)
  • A to T, chromosome 19 at 37,318,091 bp (GRCm38)
  • T to C, chromosome 19 at 37,330,402 bp (GRCm38)
  • T to A, chromosome 19 at 41,088,870 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9280 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069099-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.