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Strain Name:
C57BL/6J-MtgxR9290Btlr/Mmmh
Stock Number:
069109-MU
Citation ID:
RRID:MMRRC_069109-MU
Other Names:
R9290 (G1)
Major Collection:

Strain Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: raptor, 4932417H02Rik, Rap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74370
Homologene: 80210
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Cdkn2c
Name: cyclin dependent kinase inhibitor 2C
Synonyms: p18, INK4c, p18INK4c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12580
HGNC: HGNC:1789
Homologene: 966
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Arg, Abll
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Rbpj
Name: recombination signal binding protein for immunoglobulin kappa J region
Synonyms: CBF1, Igkrsbp, RBP-J kappa, RBPjk, Igkjrb, Rbpsuh
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19664
HGNC: HGNC:5724
Homologene: 7511
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 37,624,553 bp (GRCm38)
  • T to G, chromosome 1 at 54,438,838 bp (GRCm38)
  • T to C, chromosome 1 at 88,319,045 bp (GRCm38)
  • C to A, chromosome 1 at 93,271,663 bp (GRCm38)
  • A to G, chromosome 1 at 119,925,651 bp (GRCm38)
  • A to G, chromosome 1 at 156,629,968 bp (GRCm38)
  • A to G, chromosome 1 at 157,546,246 bp (GRCm38)
  • T to C, chromosome 1 at 174,217,638 bp (GRCm38)
  • T to C, chromosome 2 at 58,448,318 bp (GRCm38)
  • G to T, chromosome 2 at 76,647,803 bp (GRCm38)
  • A to G, chromosome 2 at 78,919,980 bp (GRCm38)
  • A to G, chromosome 2 at 87,628,865 bp (GRCm38)
  • A to G, chromosome 2 at 89,097,732 bp (GRCm38)
  • A to T, chromosome 2 at 111,944,622 bp (GRCm38)
  • G to A, chromosome 2 at 118,693,402 bp (GRCm38)
  • A to G, chromosome 2 at 121,300,533 bp (GRCm38)
  • G to T, chromosome 2 at 131,561,978 bp (GRCm38)
  • T to C, chromosome 2 at 146,223,353 bp (GRCm38)
  • A to T, chromosome 2 at 181,795,874 bp (GRCm38)
  • T to C, chromosome 3 at 28,620,975 bp (GRCm38)
  • T to C, chromosome 3 at 88,309,229 bp (GRCm38)
  • G to T, chromosome 3 at 94,324,323 bp (GRCm38)
  • G to A, chromosome 4 at 101,120,190 bp (GRCm38)
  • A to C, chromosome 4 at 109,661,315 bp (GRCm38)
  • G to T, chromosome 4 at 137,018,218 bp (GRCm38)
  • G to A, chromosome 4 at 137,718,911 bp (GRCm38)
  • T to C, chromosome 4 at 144,196,445 bp (GRCm38)
  • T to C, chromosome 5 at 21,739,011 bp (GRCm38)
  • T to C, chromosome 5 at 36,025,881 bp (GRCm38)
  • T to G, chromosome 5 at 38,297,958 bp (GRCm38)
  • T to C, chromosome 5 at 53,653,403 bp (GRCm38)
  • A to T, chromosome 6 at 15,197,121 bp (GRCm38)
  • C to T, chromosome 6 at 37,299,845 bp (GRCm38)
  • A to G, chromosome 6 at 119,320,831 bp (GRCm38)
  • T to C, chromosome 6 at 145,202,962 bp (GRCm38)
  • A to T, chromosome 7 at 12,774,127 bp (GRCm38)
  • A to G, chromosome 7 at 42,265,961 bp (GRCm38)
  • T to C, chromosome 7 at 46,774,907 bp (GRCm38)
  • T to A, chromosome 8 at 35,802,232 bp (GRCm38)
  • A to T, chromosome 8 at 93,302,917 bp (GRCm38)
  • T to A, chromosome 8 at 106,916,196 bp (GRCm38)
  • T to C, chromosome 9 at 38,582,038 bp (GRCm38)
  • A to G, chromosome 9 at 39,218,235 bp (GRCm38)
  • G to T, chromosome 9 at 56,975,263 bp (GRCm38)
  • T to C, chromosome 9 at 96,840,036 bp (GRCm38)
  • C to A, chromosome 9 at 119,061,494 bp (GRCm38)
  • A to T, chromosome 10 at 127,526,677 bp (GRCm38)
  • A to T, chromosome 11 at 119,811,997 bp (GRCm38)
  • T to A, chromosome 12 at 74,976,714 bp (GRCm38)
  • T to A, chromosome 12 at 78,712,254 bp (GRCm38)
  • C to T, chromosome 12 at 118,027,516 bp (GRCm38)
  • G to A, chromosome 13 at 23,163,229 bp (GRCm38)
  • A to G, chromosome 13 at 25,202,330 bp (GRCm38)
  • A to T, chromosome 13 at 40,280,326 bp (GRCm38)
  • A to T, chromosome 13 at 48,586,745 bp (GRCm38)
  • T to C, chromosome 13 at 54,734,196 bp (GRCm38)
  • T to A, chromosome 13 at 78,025,466 bp (GRCm38)
  • A to T, chromosome 13 at 95,750,015 bp (GRCm38)
  • G to A, chromosome 14 at 61,184,050 bp (GRCm38)
  • A to T, chromosome 14 at 65,817,264 bp (GRCm38)
  • A to T, chromosome 14 at 103,188,524 bp (GRCm38)
  • T to A, chromosome 16 at 10,508,649 bp (GRCm38)
  • A to G, chromosome 16 at 49,177,012 bp (GRCm38)
  • C to T, chromosome 17 at 19,591,133 bp (GRCm38)
  • A to G, chromosome 18 at 59,409,856 bp (GRCm38)
  • G to T, chromosome 19 at 17,168,327 bp (GRCm38)
  • A to G, chromosome 19 at 30,078,016 bp (GRCm38)
  • A to T, chromosome 19 at 37,325,248 bp (GRCm38)
  • A to G, chromosome 19 at 60,776,783 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9290 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069109-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.