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Strain Name:
C57BL/6J-MtgxR9342Btlr/Mmmh
Stock Number:
069153-MU
Citation ID:
RRID:MMRRC_069153-MU
Other Names:
R9342 (G1)
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Ppp1r17
Name: protein phosphatase 1, regulatory subunit 17
Synonyms: G-substrate, Gsbs
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19051
Homologene: 4849
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 170750
Homologene: 6424
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Eca39, BCATc, Bcat-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 14,755,483 bp (GRCm38)
  • A to T, chromosome 1 at 80,592,643 bp (GRCm38)
  • A to G, chromosome 1 at 87,098,664 bp (GRCm38)
  • A to G, chromosome 1 at 90,144,966 bp (GRCm38)
  • A to T, chromosome 1 at 165,855,190 bp (GRCm38)
  • T to C, chromosome 2 at 11,749,603 bp (GRCm38)
  • T to A, chromosome 2 at 13,458,956 bp (GRCm38)
  • T to C, chromosome 2 at 27,230,857 bp (GRCm38)
  • T to A, chromosome 2 at 35,723,093 bp (GRCm38)
  • A to G, chromosome 2 at 74,692,638 bp (GRCm38)
  • A to T, chromosome 2 at 82,988,403 bp (GRCm38)
  • A to T, chromosome 2 at 86,677,150 bp (GRCm38)
  • A to T, chromosome 2 at 104,787,819 bp (GRCm38)
  • A to G, chromosome 2 at 119,948,175 bp (GRCm38)
  • G to A, chromosome 2 at 132,340,870 bp (GRCm38)
  • T to C, chromosome 2 at 132,870,370 bp (GRCm38)
  • T to C, chromosome 2 at 156,035,276 bp (GRCm38)
  • G to A, chromosome 3 at 58,626,680 bp (GRCm38)
  • C to T, chromosome 3 at 58,884,830 bp (GRCm38)
  • T to A, chromosome 3 at 66,244,538 bp (GRCm38)
  • T to G, chromosome 3 at 95,303,048 bp (GRCm38)
  • T to A, chromosome 3 at 101,835,203 bp (GRCm38)
  • T to A, chromosome 3 at 108,413,126 bp (GRCm38)
  • T to C, chromosome 3 at 152,186,635 bp (GRCm38)
  • T to C, chromosome 4 at 43,943,301 bp (GRCm38)
  • T to A, chromosome 4 at 111,779,192 bp (GRCm38)
  • T to C, chromosome 4 at 126,098,067 bp (GRCm38)
  • A to G, chromosome 4 at 143,134,908 bp (GRCm38)
  • G to A, chromosome 5 at 24,573,477 bp (GRCm38)
  • G to A, chromosome 5 at 109,220,562 bp (GRCm38)
  • T to C, chromosome 5 at 130,379,035 bp (GRCm38)
  • A to G, chromosome 5 at 137,653,852 bp (GRCm38)
  • T to A, chromosome 6 at 56,026,539 bp (GRCm38)
  • A to G, chromosome 6 at 90,466,869 bp (GRCm38)
  • A to G, chromosome 6 at 119,057,374 bp (GRCm38)
  • T to C, chromosome 6 at 119,320,973 bp (GRCm38)
  • T to C, chromosome 6 at 125,363,060 bp (GRCm38)
  • A to G, chromosome 6 at 145,048,606 bp (GRCm38)
  • A to G, chromosome 7 at 12,771,685 bp (GRCm38)
  • T to A, chromosome 7 at 30,977,760 bp (GRCm38)
  • A to G, chromosome 7 at 68,194,998 bp (GRCm38)
  • C to A, chromosome 7 at 74,504,289 bp (GRCm38)
  • A to G, chromosome 7 at 85,136,580 bp (GRCm38)
  • A to G, chromosome 7 at 85,233,785 bp (GRCm38)
  • T to C, chromosome 7 at 85,957,416 bp (GRCm38)
  • A to G, chromosome 7 at 86,413,222 bp (GRCm38)
  • A to T, chromosome 7 at 106,927,357 bp (GRCm38)
  • C to A, chromosome 7 at 141,455,418 bp (GRCm38)
  • C to A, chromosome 8 at 9,771,006 bp (GRCm38)
  • T to C, chromosome 8 at 110,222,446 bp (GRCm38)
  • C to T, chromosome 8 at 122,334,569 bp (GRCm38)
  • A to G, chromosome 9 at 49,440,380 bp (GRCm38)
  • A to T, chromosome 9 at 78,095,238 bp (GRCm38)
  • T to C, chromosome 9 at 105,785,973 bp (GRCm38)
  • T to C, chromosome 9 at 120,016,884 bp (GRCm38)
  • A to G, chromosome 10 at 24,874,571 bp (GRCm38)
  • T to C, chromosome 10 at 39,821,462 bp (GRCm38)
  • A to T, chromosome 10 at 121,267,461 bp (GRCm38)
  • T to C, chromosome 11 at 65,690,743 bp (GRCm38)
  • T to A, chromosome 11 at 70,436,637 bp (GRCm38)
  • T to A, chromosome 11 at 99,538,753 bp (GRCm38)
  • T to A, chromosome 11 at 101,258,797 bp (GRCm38)
  • T to C, chromosome 11 at 117,739,894 bp (GRCm38)
  • T to C, chromosome 12 at 72,459,993 bp (GRCm38)
  • A to C, chromosome 12 at 109,592,450 bp (GRCm38)
  • A to G, chromosome 13 at 21,526,532 bp (GRCm38)
  • T to G, chromosome 13 at 54,214,203 bp (GRCm38)
  • A to T, chromosome 13 at 61,287,664 bp (GRCm38)
  • A to G, chromosome 13 at 112,994,381 bp (GRCm38)
  • T to A, chromosome 14 at 14,772,541 bp (GRCm38)
  • G to T, chromosome 14 at 30,797,642 bp (GRCm38)
  • T to C, chromosome 15 at 35,455,054 bp (GRCm38)
  • T to C, chromosome 15 at 53,345,128 bp (GRCm38)
  • A to G, chromosome 16 at 32,479,699 bp (GRCm38)
  • A to G, chromosome 17 at 18,929,106 bp (GRCm38)
  • A to C, chromosome 17 at 31,127,449 bp (GRCm38)
  • A to T, chromosome 17 at 36,460,393 bp (GRCm38)
  • A to G, chromosome 17 at 45,507,076 bp (GRCm38)
  • A to G, chromosome 17 at 86,474,449 bp (GRCm38)
  • T to A, chromosome 18 at 84,965,484 bp (GRCm38)
  • A to G, chromosome 19 at 5,108,631 bp (GRCm38)
  • G to A, chromosome 19 at 8,880,726 bp (GRCm38)
  • T to A, chromosome 19 at 11,142,411 bp (GRCm38)
  • T to A, chromosome 19 at 53,004,817 bp (GRCm38)
  • A to G, chromosome 19 at 55,743,085 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9342 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069153-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.