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Strain Name:
C57BL/6J-MtgxR9414Btlr/Mmmh
Stock Number:
069218-MU
Citation ID:
RRID:MMRRC_069218-MU
Other Names:
R9414 (G1)
Major Collection:

Strain Information

Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: paladin, X99384
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27355
VEGA: 10
Homologene: 8453
Mmp10
Name: matrix metallopeptidase 10
Synonyms: stromelysin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17384
VEGA: 9
HGNC: HGNC:7156
Homologene: 20546
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228829
Homologene: 9507
Prdx2
Name: peroxiredoxin 2
Synonyms: TPx, thioredoxin reductase, TR, Prx II-1, Trx dependent peroxide reductase 1, thiol specific antioxidant protein, TSA, thioredoxin dependent peroxide reductase 1, TDX1, thioredoxin peroxidase, protector protein, PRP, Tdpx1, PrxII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21672
HGNC: HGNC:9353
Homologene: 21182
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: B930007L02Rik, Vprbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Supt20
Name: SPT20 SAGA complex component
Synonyms: p38 interacting protein, p38IP, D3Ertd300e, Fam48a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56790
Homologene: 134155
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 4,243,618 bp (GRCm38)
  • T to C, chromosome 1 at 36,184,426 bp (GRCm38)
  • C to T, chromosome 1 at 88,251,374 bp (GRCm38)
  • T to C, chromosome 1 at 133,657,277 bp (GRCm38)
  • T to G, chromosome 1 at 150,669,436 bp (GRCm38)
  • C to T, chromosome 1 at 170,302,604 bp (GRCm38)
  • T to C, chromosome 1 at 171,599,707 bp (GRCm38)
  • C to T, chromosome 2 at 24,648,502 bp (GRCm38)
  • G to T, chromosome 2 at 71,118,223 bp (GRCm38)
  • C to T, chromosome 2 at 112,670,666 bp (GRCm38)
  • T to C, chromosome 2 at 121,140,140 bp (GRCm38)
  • T to C, chromosome 2 at 156,294,247 bp (GRCm38)
  • T to C, chromosome 2 at 160,761,356 bp (GRCm38)
  • T to C, chromosome 2 at 164,168,458 bp (GRCm38)
  • T to A, chromosome 3 at 54,703,083 bp (GRCm38)
  • T to C, chromosome 3 at 100,182,755 bp (GRCm38)
  • T to C, chromosome 3 at 132,906,355 bp (GRCm38)
  • T to A, chromosome 3 at 138,547,734 bp (GRCm38)
  • G to A, chromosome 4 at 131,974,851 bp (GRCm38)
  • A to G, chromosome 5 at 33,729,954 bp (GRCm38)
  • T to C, chromosome 5 at 52,796,622 bp (GRCm38)
  • T to A, chromosome 5 at 108,419,726 bp (GRCm38)
  • T to C, chromosome 6 at 39,383,921 bp (GRCm38)
  • T to A, chromosome 6 at 87,085,283 bp (GRCm38)
  • T to C, chromosome 7 at 4,010,820 bp (GRCm38)
  • T to C, chromosome 7 at 30,582,882 bp (GRCm38)
  • T to A, chromosome 7 at 45,003,292 bp (GRCm38)
  • A to G, chromosome 7 at 96,896,160 bp (GRCm38)
  • A to C, chromosome 7 at 97,664,558 bp (GRCm38)
  • T to A, chromosome 7 at 109,027,058 bp (GRCm38)
  • G to A, chromosome 7 at 127,881,878 bp (GRCm38)
  • C to A, chromosome 7 at 140,652,350 bp (GRCm38)
  • T to G, chromosome 8 at 3,656,908 bp (GRCm38)
  • CAGCATCTGCTCGGAGCA to CAGCA, chromosome 8 at 26,160,856 bp (GRCm38)
  • T to C, chromosome 8 at 84,970,567 bp (GRCm38)
  • A to T, chromosome 8 at 119,768,342 bp (GRCm38)
  • A to T, chromosome 9 at 7,502,488 bp (GRCm38)
  • G to A, chromosome 9 at 36,867,951 bp (GRCm38)
  • A to G, chromosome 9 at 57,136,746 bp (GRCm38)
  • G to A, chromosome 9 at 106,879,959 bp (GRCm38)
  • A to G, chromosome 9 at 107,515,196 bp (GRCm38)
  • A to G, chromosome 10 at 59,222,669 bp (GRCm38)
  • G to T, chromosome 10 at 61,343,153 bp (GRCm38)
  • T to C, chromosome 10 at 62,839,156 bp (GRCm38)
  • T to G, chromosome 10 at 115,414,011 bp (GRCm38)
  • A to T, chromosome 11 at 59,794,172 bp (GRCm38)
  • G to T, chromosome 11 at 73,111,803 bp (GRCm38)
  • T to A, chromosome 11 at 73,711,197 bp (GRCm38)
  • A to T, chromosome 11 at 110,144,274 bp (GRCm38)
  • G to T, chromosome 12 at 81,918,204 bp (GRCm38)
  • G to T, chromosome 13 at 59,462,088 bp (GRCm38)
  • T to C, chromosome 13 at 95,646,841 bp (GRCm38)
  • T to A, chromosome 13 at 100,161,735 bp (GRCm38)
  • A to G, chromosome 14 at 122,436,192 bp (GRCm38)
  • A to G, chromosome 16 at 4,107,492 bp (GRCm38)
  • A to G, chromosome 16 at 18,397,715 bp (GRCm38)
  • A to G, chromosome 16 at 58,718,153 bp (GRCm38)
  • G to A, chromosome 16 at 58,890,202 bp (GRCm38)
  • T to A, chromosome 17 at 20,029,988 bp (GRCm38)
  • T to C, chromosome 17 at 27,708,011 bp (GRCm38)
  • A to G, chromosome 18 at 31,771,909 bp (GRCm38)
  • T to C, chromosome 19 at 6,344,485 bp (GRCm38)
  • T to C, chromosome 19 at 12,680,348 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9414 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069218-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.