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Strain Name:
C57BL/6J-MtgxR9427Btlr/Mmmh
Stock Number:
069231-MU
Citation ID:
RRID:MMRRC_069231-MU
Other Names:
R9427 (G1)
Major Collection:

Strain Information

Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: Stat3-interacting protein, StIP1, Statip1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: 1810048F20Rik, Fthfd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Etv5
Name: ets variant 5
Synonyms: 8430401F14Rik, erm, 1110005E01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104156
HGNC: HGNC:3494
Homologene: 3276
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Prdm5
Name: PR domain containing 5
Synonyms: 6530401I24Rik, E130112L17Rik, PFM2, 4432417F03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to A, chromosome 1 at 59,120,054 bp (GRCm38)
  • G to A, chromosome 1 at 66,554,999 bp (GRCm38)
  • A to T, chromosome 1 at 111,859,695 bp (GRCm38)
  • A to T, chromosome 1 at 136,084,352 bp (GRCm38)
  • C to T, chromosome 2 at 76,885,013 bp (GRCm38)
  • T to C, chromosome 2 at 85,918,360 bp (GRCm38)
  • T to C, chromosome 2 at 103,700,899 bp (GRCm38)
  • A to G, chromosome 3 at 64,134,524 bp (GRCm38)
  • T to C, chromosome 3 at 76,322,276 bp (GRCm38)
  • T to C, chromosome 3 at 87,743,061 bp (GRCm38)
  • C to T, chromosome 3 at 90,199,866 bp (GRCm38)
  • A to G, chromosome 3 at 138,115,201 bp (GRCm38)
  • T to C, chromosome 3 at 148,820,432 bp (GRCm38)
  • G to C, chromosome 4 at 47,288,200 bp (GRCm38)
  • T to C, chromosome 4 at 58,069,804 bp (GRCm38)
  • T to A, chromosome 4 at 76,133,203 bp (GRCm38)
  • G to A, chromosome 4 at 135,698,831 bp (GRCm38)
  • A to G, chromosome 4 at 136,021,624 bp (GRCm38)
  • A to T, chromosome 5 at 134,657,504 bp (GRCm38)
  • A to T, chromosome 6 at 56,779,147 bp (GRCm38)
  • T to C, chromosome 6 at 57,659,737 bp (GRCm38)
  • T to A, chromosome 6 at 65,794,337 bp (GRCm38)
  • A to G, chromosome 6 at 90,559,921 bp (GRCm38)
  • A to G, chromosome 6 at 142,268,275 bp (GRCm38)
  • T to G, chromosome 7 at 3,894,285 bp (GRCm38)
  • T to C, chromosome 7 at 45,358,789 bp (GRCm38)
  • G to GACGGCGGCC, chromosome 7 at 97,579,909 bp (GRCm38)
  • T to A, chromosome 7 at 102,493,999 bp (GRCm38)
  • G to T, chromosome 7 at 126,149,246 bp (GRCm38)
  • A to T, chromosome 9 at 16,377,395 bp (GRCm38)
  • G to A, chromosome 9 at 51,843,691 bp (GRCm38)
  • T to C, chromosome 9 at 79,682,163 bp (GRCm38)
  • T to C, chromosome 9 at 97,365,821 bp (GRCm38)
  • T to C, chromosome 9 at 105,939,793 bp (GRCm38)
  • A to G, chromosome 10 at 78,847,072 bp (GRCm38)
  • C to T, chromosome 10 at 79,035,561 bp (GRCm38)
  • A to G, chromosome 10 at 85,976,265 bp (GRCm38)
  • A to C, chromosome 10 at 115,453,008 bp (GRCm38)
  • T to C, chromosome 10 at 115,833,308 bp (GRCm38)
  • T to C, chromosome 11 at 106,262,477 bp (GRCm38)
  • C to A, chromosome 12 at 111,681,056 bp (GRCm38)
  • T to C, chromosome 13 at 81,584,115 bp (GRCm38)
  • G to A, chromosome 14 at 14,328,456 bp (GRCm38)
  • G to A, chromosome 14 at 30,036,849 bp (GRCm38)
  • T to A, chromosome 14 at 30,689,824 bp (GRCm38)
  • T to C, chromosome 14 at 44,403,609 bp (GRCm38)
  • A to C, chromosome 14 at 74,795,347 bp (GRCm38)
  • A to C, chromosome 16 at 22,399,362 bp (GRCm38)
  • T to C, chromosome 16 at 43,662,152 bp (GRCm38)
  • A to T, chromosome 17 at 17,575,347 bp (GRCm38)
  • CCTGCTGCTGCTGCTGCTG to CCTGCTGCTGCTGCTG, chromosome 17 at 87,370,719 bp (GRCm38)
  • C to G, chromosome 18 at 24,622,503 bp (GRCm38)
  • A to T, chromosome 18 at 62,511,089 bp (GRCm38)
  • T to C, chromosome 19 at 12,422,525 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9427 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069231-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.