Strain Name:
C57BL/6J-MtgxR9442Btlr/Mmmh
Stock Number:
069246-MU
Citation ID:
RRID:MMRRC_069246-MU
Other Names:
R9442 (G1)
Major Collection:

Strain Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1-D, NFATp, NFAT1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: LUCA-1, SemA, sema5, Semaa, semaV, SemA
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-Ma, H2-M alpha, H-2Ma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Orc1
Name: origin recognition complex, subunit 1
Synonyms: Orc1l, MmORC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: E130113K22Rik, CGI-72
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
St13
Name: suppression of tumorigenicity 13
Synonyms: 3110002K08Rik, p48, PRO0786, Hsp70 interacting protein, 1110007I03Rik, SNC6, HSPABP1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70356
Homologene: 2921
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20133
Homologene: 806
Stag1
Name: STAG1 cohesin complex component
Synonyms: SA-1, Scc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20842
Homologene: 21191
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Gmeb1
Name: glucocorticoid modulatory element binding protein 1
Synonyms: 1110050A04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56809
HGNC: HGNC:4370
Homologene: 10647
Ntn1
Name: netrin 1
Synonyms: Netrin-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18208
HGNC: HGNC:8029
Homologene: 21008
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: C130040G20Rik, Dbs
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17207
Homologene: 11804
Epha6
Name: Eph receptor A6
Synonyms: m-ehk2, Hek12, Ehk2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13840
Homologene: 56396
Ms4a6c
Name: membrane-spanning 4-domains, subfamily A, member 6C
Synonyms: 2210417N07Rik, 2200009H22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73656
Homologene: 130765
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Nlrp9b
Name: NLR family, pyrin domain containing 9B
Synonyms: Nalp9b, Nalp-delta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243874
Homologene: 18530
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Cenpt
Name: centromere protein T
Synonyms: G630055P03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320394
Homologene: 41610
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, LOC383304, 1700013J13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Or14j3
Name: olfactory receptor family 14 subfamily J member 3
Synonyms: Olfr114, GA_x6K02T2PSCP-2049802-2048870, MOR218-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258284
Homologene: 133642
Ccndbp1
Name: cyclin D-type binding-protein 1
Synonyms: stage specific embryonic cDNA-8, Maid, DIP1, GCIP, SSEC-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17151
HGNC: HGNC:1587
Homologene: 7826
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: Raftk, CAKbeta, cellular adhesion kinase beta, proline-rich tyrosine kinase 2, related adhesion focal tyrosine kinase, E430023O05Rik, PYK2, calcium-dependent tyrosine kinase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Lrrc8e
Name: leucine rich repeat containing 8 family, member E
Synonyms: 1810049O03Rik, C87354
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72267
Homologene: 11817
Zfp438
Name: zinc finger protein 438
Synonyms: 9430091M14Rik, B830013J05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240186
VEGA: 18
Homologene: 18695
Psg18
Name: pregnancy specific beta-1-glycoprotein 18
Synonyms: Cea-3, Cea3, mmCGM6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26438
HGNC: HGNC:9524
Homologene: 110989
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mt2, Mel1b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Cyp4a32
Name: cytochrome P450, family 4, subfamily a, polypeptide 32
Synonyms: OTTMUSG00000008689
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100040843
HGNC: HGNC:2642
Homologene: 128044
Setdb2
Name: SET domain, bifurcated 2
Synonyms: KMT1F, LOC239122
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Svs3a
Name: seminal vesicle secretory protein 3A
Synonyms: Svp3, 9530026M05Rik, SVS III, Svp-3, Svs3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64335
Homologene: 110771
Cage1
Name: cancer antigen 1
Synonyms: Ctag3, 4933427I01Rik, CAGE1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71213
Homologene: 18484
Sorbs3
Name: sorbin and SH3 domain containing 3
Synonyms: SH3P3, vinexin beta, vinexin alpha, Sh3d4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20410
VEGA: 14
Homologene: 4218
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Kcnrg
Name: potassium channel regulator
Synonyms: E030012H22Rik, LOC328424
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328424
VEGA: 14
Homologene: 35259
Vmn1r180
Name: vomeronasal 1 receptor 180
Synonyms: LOC232962, V1rd16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232962
Homologene: 104166
Krtap14
Name: keratin associated protein 14
Synonyms: Pmg1, mKAP13
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23927
Homologene: 56600
Selp
Name: selectin, platelet
Synonyms: P-selectin, CD62P, Grmp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20344
Homologene: 2260
1700122O11Rik
Name: RIKEN cDNA 1700122O11 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76651
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Catspere2
Name: cation channel sperm associated auxiliary subunit epsilon 2
Synonyms: EG545391, Gm30473, Gm16432
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545391
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 75,186,442 bp (GRCm38)
  • T to A, chromosome 1 at 164,137,196 bp (GRCm38)
  • C to A, chromosome 1 at 178,103,709 bp (GRCm38)
  • T to A, chromosome 2 at 67,511,891 bp (GRCm38)
  • T to C, chromosome 2 at 121,008,532 bp (GRCm38)
  • A to G, chromosome 2 at 164,290,259 bp (GRCm38)
  • A to C, chromosome 2 at 168,486,978 bp (GRCm38)
  • T to C, chromosome 4 at 108,612,160 bp (GRCm38)
  • T to A, chromosome 4 at 115,611,225 bp (GRCm38)
  • A to G, chromosome 4 at 118,606,534 bp (GRCm38)
  • A to T, chromosome 4 at 132,234,845 bp (GRCm38)
  • A to T, chromosome 7 at 18,349,260 bp (GRCm38)
  • C to T, chromosome 7 at 20,045,782 bp (GRCm38)
  • A to G, chromosome 7 at 23,952,195 bp (GRCm38)
  • A to G, chromosome 7 at 102,459,391 bp (GRCm38)
  • A to G, chromosome 8 at 4,233,964 bp (GRCm38)
  • A to G, chromosome 8 at 12,973,048 bp (GRCm38)
  • A to T, chromosome 8 at 24,806,494 bp (GRCm38)
  • T to C, chromosome 8 at 105,848,786 bp (GRCm38)
  • T to C, chromosome 9 at 15,874,364 bp (GRCm38)
  • T to A, chromosome 9 at 18,655,328 bp (GRCm38)
  • T to A, chromosome 9 at 100,954,253 bp (GRCm38)
  • A to G, chromosome 9 at 107,601,758 bp (GRCm38)
  • A to C, chromosome 11 at 68,257,659 bp (GRCm38)
  • T to G, chromosome 12 at 114,538,578 bp (GRCm38)
  • T to C, chromosome 13 at 38,012,471 bp (GRCm38)
  • A to G, chromosome 13 at 67,591,218 bp (GRCm38)
  • T to G, chromosome 14 at 59,402,400 bp (GRCm38)
  • CACAACAA to CACAA, chromosome 14 at 61,607,560 bp (GRCm38)
  • T to C, chromosome 14 at 66,171,740 bp (GRCm38)
  • T to C, chromosome 14 at 70,186,938 bp (GRCm38)
  • C to T, chromosome 15 at 66,613,039 bp (GRCm38)
  • G to A, chromosome 15 at 81,388,374 bp (GRCm38)
  • A to C, chromosome 16 at 34,095,879 bp (GRCm38)
  • T to C, chromosome 16 at 60,205,487 bp (GRCm38)
  • T to C, chromosome 16 at 88,825,977 bp (GRCm38)
  • G to A, chromosome 17 at 34,138,158 bp (GRCm38)
  • A to G, chromosome 17 at 37,589,742 bp (GRCm38)
  • T to A, chromosome 17 at 48,036,771 bp (GRCm38)
  • T to C, chromosome 17 at 56,270,428 bp (GRCm38)
  • A to G, chromosome 18 at 5,214,379 bp (GRCm38)
  • A to T, chromosome 18 at 22,769,842 bp (GRCm38)
  • T to A, chromosome 19 at 6,342,784 bp (GRCm38)
  • T to C, chromosome 19 at 6,855,845 bp (GRCm38)
  • T to C, chromosome 19 at 11,472,487 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9442 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069246-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.