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Strain Name:
C57BL/6J-MtgxR9442Btlr/Mmmh
Stock Number:
069246-MU
Citation ID:
RRID:MMRRC_069246-MU
Other Names:
R9442 (G1)
Major Collection:

Strain Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1, NFATp, NFAT1-D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: SemA, semaV, sema5, SemA, LUCA-1, Semaa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-Ma, H-2Ma, H2-M alpha
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Orc1
Name: origin recognition complex, subunit 1
Synonyms: MmORC1, Orc1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: CGI-72, E130113K22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
St13
Name: suppression of tumorigenicity 13
Synonyms: PRO0786, HSPABP1, SNC6, p48, Hsp70 interacting protein, 3110002K08Rik, 1110007I03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70356
Homologene: 2921
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20133
Homologene: 806
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 75,186,442 bp (GRCm38)
  • T to A, chromosome 1 at 164,137,196 bp (GRCm38)
  • C to A, chromosome 1 at 178,103,709 bp (GRCm38)
  • T to A, chromosome 2 at 67,511,891 bp (GRCm38)
  • T to C, chromosome 2 at 121,008,532 bp (GRCm38)
  • A to G, chromosome 2 at 164,290,259 bp (GRCm38)
  • A to C, chromosome 2 at 168,486,978 bp (GRCm38)
  • T to C, chromosome 4 at 108,612,160 bp (GRCm38)
  • T to A, chromosome 4 at 115,611,225 bp (GRCm38)
  • A to G, chromosome 4 at 118,606,534 bp (GRCm38)
  • A to T, chromosome 4 at 132,234,845 bp (GRCm38)
  • A to T, chromosome 7 at 18,349,260 bp (GRCm38)
  • C to T, chromosome 7 at 20,045,782 bp (GRCm38)
  • A to G, chromosome 7 at 23,952,195 bp (GRCm38)
  • A to G, chromosome 7 at 102,459,391 bp (GRCm38)
  • A to G, chromosome 8 at 4,233,964 bp (GRCm38)
  • A to G, chromosome 8 at 12,973,048 bp (GRCm38)
  • A to T, chromosome 8 at 24,806,494 bp (GRCm38)
  • T to C, chromosome 8 at 105,848,786 bp (GRCm38)
  • T to C, chromosome 9 at 15,874,364 bp (GRCm38)
  • T to A, chromosome 9 at 18,655,328 bp (GRCm38)
  • T to A, chromosome 9 at 100,954,253 bp (GRCm38)
  • A to G, chromosome 9 at 107,601,758 bp (GRCm38)
  • A to C, chromosome 11 at 68,257,659 bp (GRCm38)
  • T to G, chromosome 12 at 114,538,578 bp (GRCm38)
  • T to C, chromosome 13 at 38,012,471 bp (GRCm38)
  • A to G, chromosome 13 at 67,591,218 bp (GRCm38)
  • T to G, chromosome 14 at 59,402,400 bp (GRCm38)
  • CACAACAA to CACAA, chromosome 14 at 61,607,560 bp (GRCm38)
  • T to C, chromosome 14 at 66,171,740 bp (GRCm38)
  • T to C, chromosome 14 at 70,186,938 bp (GRCm38)
  • C to T, chromosome 15 at 66,613,039 bp (GRCm38)
  • G to A, chromosome 15 at 81,388,374 bp (GRCm38)
  • A to C, chromosome 16 at 34,095,879 bp (GRCm38)
  • T to C, chromosome 16 at 60,205,487 bp (GRCm38)
  • T to C, chromosome 16 at 88,825,977 bp (GRCm38)
  • G to A, chromosome 17 at 34,138,158 bp (GRCm38)
  • A to G, chromosome 17 at 37,589,742 bp (GRCm38)
  • T to A, chromosome 17 at 48,036,771 bp (GRCm38)
  • T to C, chromosome 17 at 56,270,428 bp (GRCm38)
  • A to G, chromosome 18 at 5,214,379 bp (GRCm38)
  • A to T, chromosome 18 at 22,769,842 bp (GRCm38)
  • T to A, chromosome 19 at 6,342,784 bp (GRCm38)
  • T to C, chromosome 19 at 6,855,845 bp (GRCm38)
  • T to C, chromosome 19 at 11,472,487 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9442 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069246-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.