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Strain Name:
C57BL/6J-MtgxR9468Btlr/Mmmh
Stock Number:
069271-MU
Citation ID:
RRID:MMRRC_069271-MU
Other Names:
R9468 (G1)
Major Collection:

Strain Information

Krt5
Name: keratin 5
Synonyms: 3300001P10Rik, Tfip8, K5, Krt2-5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110308
HGNC: HGNC:6442
Homologene: 55461
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226409
Homologene: 32770
Ndc80
Name: NDC80 kinetochore complex component
Synonyms: HEC1, 2610020P18Rik, Kntc2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67052
VEGA: 17
Homologene: 38141
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Ccz1
Name: CCZ1 vacuolar protein trafficking and biogenesis associated
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231874
Homologene: 56717
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208628
Homologene: 32227
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 38,800,758 bp (GRCm38)
  • A to G, chromosome 1 at 127,963,759 bp (GRCm38)
  • G to T, chromosome 1 at 130,874,214 bp (GRCm38)
  • A to G, chromosome 1 at 138,117,016 bp (GRCm38)
  • T to A, chromosome 1 at 161,957,167 bp (GRCm38)
  • T to C, chromosome 2 at 25,273,120 bp (GRCm38)
  • T to G, chromosome 2 at 76,705,768 bp (GRCm38)
  • T to A, chromosome 2 at 87,371,772 bp (GRCm38)
  • C to T, chromosome 2 at 88,865,451 bp (GRCm38)
  • T to C, chromosome 2 at 174,091,534 bp (GRCm38)
  • A to T, chromosome 3 at 40,976,555 bp (GRCm38)
  • A to T, chromosome 4 at 41,404,794 bp (GRCm38)
  • A to T, chromosome 4 at 94,638,284 bp (GRCm38)
  • A to G, chromosome 4 at 118,476,179 bp (GRCm38)
  • A to T, chromosome 4 at 120,711,297 bp (GRCm38)
  • A to G, chromosome 4 at 126,907,200 bp (GRCm38)
  • C to T, chromosome 5 at 65,080,188 bp (GRCm38)
  • T to C, chromosome 5 at 123,816,713 bp (GRCm38)
  • G to T, chromosome 5 at 143,992,620 bp (GRCm38)
  • C to T, chromosome 5 at 147,042,479 bp (GRCm38)
  • T to C, chromosome 6 at 34,415,381 bp (GRCm38)
  • T to C, chromosome 6 at 43,559,967 bp (GRCm38)
  • T to C, chromosome 6 at 70,913,643 bp (GRCm38)
  • T to A, chromosome 6 at 90,129,948 bp (GRCm38)
  • G to T, chromosome 7 at 22,790,463 bp (GRCm38)
  • G to A, chromosome 7 at 29,073,085 bp (GRCm38)
  • A to T, chromosome 7 at 29,710,007 bp (GRCm38)
  • A to G, chromosome 7 at 30,585,088 bp (GRCm38)
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,920 bp (GRCm38)
  • A to T, chromosome 7 at 99,735,973 bp (GRCm38)
  • C to T, chromosome 7 at 108,395,642 bp (GRCm38)
  • T to A, chromosome 8 at 40,354,381 bp (GRCm38)
  • G to A, chromosome 8 at 104,420,626 bp (GRCm38)
  • T to A, chromosome 8 at 110,671,106 bp (GRCm38)
  • A to T, chromosome 8 at 122,813,030 bp (GRCm38)
  • T to A, chromosome 9 at 18,302,129 bp (GRCm38)
  • A to G, chromosome 9 at 36,911,199 bp (GRCm38)
  • T to C, chromosome 9 at 42,124,088 bp (GRCm38)
  • A to G, chromosome 9 at 89,998,703 bp (GRCm38)
  • A to G, chromosome 9 at 123,610,351 bp (GRCm38)
  • A to T, chromosome 10 at 62,464,737 bp (GRCm38)
  • A to G, chromosome 10 at 116,277,369 bp (GRCm38)
  • A to G, chromosome 11 at 4,075,200 bp (GRCm38)
  • A to G, chromosome 11 at 5,338,696 bp (GRCm38)
  • T to A, chromosome 11 at 40,723,487 bp (GRCm38)
  • C to T, chromosome 11 at 67,306,904 bp (GRCm38)
  • T to C, chromosome 11 at 72,923,183 bp (GRCm38)
  • G to A, chromosome 11 at 86,490,416 bp (GRCm38)
  • A to G, chromosome 11 at 120,362,457 bp (GRCm38)
  • T to A, chromosome 11 at 120,595,964 bp (GRCm38)
  • C to T, chromosome 12 at 76,560,235 bp (GRCm38)
  • A to G, chromosome 12 at 100,140,009 bp (GRCm38)
  • T to A, chromosome 13 at 44,919,830 bp (GRCm38)
  • T to A, chromosome 14 at 33,544,475 bp (GRCm38)
  • A to G, chromosome 14 at 61,024,174 bp (GRCm38)
  • T to C, chromosome 15 at 84,805,098 bp (GRCm38)
  • C to A, chromosome 15 at 101,707,545 bp (GRCm38)
  • G to T, chromosome 15 at 103,753,769 bp (GRCm38)
  • A to T, chromosome 16 at 17,336,315 bp (GRCm38)
  • C to T, chromosome 16 at 90,229,399 bp (GRCm38)
  • T to A, chromosome 16 at 91,657,551 bp (GRCm38)
  • G to A, chromosome 17 at 21,929,441 bp (GRCm38)
  • G to T, chromosome 17 at 36,260,600 bp (GRCm38)
  • G to A, chromosome 17 at 71,499,311 bp (GRCm38)
  • T to A, chromosome 18 at 37,478,429 bp (GRCm38)
  • A to T, chromosome 19 at 4,294,924 bp (GRCm38)
  • A to T, chromosome 19 at 4,447,716 bp (GRCm38)
  • A to T, chromosome 19 at 39,307,722 bp (GRCm38)
  • A to G, chromosome 19 at 40,180,445 bp (GRCm38)
  • G to A, chromosome 19 at 56,342,200 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9468 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069271-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.