Strain Name:
C57BL/6J-MtgxR9472Btlr/Mmmh
Stock Number:
069275-MU
Citation ID:
RRID:MMRRC_069275-MU
Other Names:
R9472 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: B430219L04Rik, mMTMH1, 4833411B01Rik, SBF2, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Cdh1
Name: cadherin 1
Synonyms: Ecad, E-cadherin, E-cad, L-CAM, UM, uvomorulin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12550
HGNC: HGNC:1748
Homologene: 20917
Gsn
Name: gelsolin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Ino80e
Name: INO80 complex subunit E
Synonyms: Ccdc95
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233875
Homologene: 17792
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328977
Homologene: 138627
Orc4
Name: origin recognition complex, subunit 4
Synonyms: Orc4P, Orc4l, Orc4, mMmORC4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26428
HGNC: HGNC:8490
Homologene: 8059
Agrn
Name: agrin
Synonyms: nmf380, NMF380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms: Ku p70, G22p1, Ku70
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14375
HGNC: HGNC:4055
Homologene: 37483
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Walp3, C030005G16Rik, Tip5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, ALL-1, Mll1, Cxxc7, Mll, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Spast
Name: spastin
Synonyms: Spg4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50850
VEGA: 17
Homologene: 8970
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F37S1, D7H15F32S1, rjs, jdf2, D15F32S1h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Rsbn1l
Name: round spermatid basic protein 1-like
Synonyms: C330002G24Rik, 8430412F05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242860
Homologene: 19435
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Dtgn3, Adam27
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70422
Homologene: 10801
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98432
Homologene: 11015
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229055
Homologene: 11395
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Mt2
Name: metallothionein 2
Synonyms: MT-II, Mt-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17750
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: 1110051E14Rik, Gcn5l2, Gcn5, PCAF-B/GCN5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Sgtb
Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
Synonyms: C630001O05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218544
Homologene: 10409
Tmprss7
Name: transmembrane serine protease 7
Synonyms: matriptase-3, B230219I23Rik, LOC385645
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Ctsb
Name: cathepsin B
Synonyms: CB
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13030
VEGA: 14
HGNC: HGNC:2527
Homologene: 37550
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 4930565N16Rik, LGL3, 0710001E20Rik, tomosyn 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78808
Homologene: 16402
Enkur
Name: enkurin, TRPC channel interacting protein
Synonyms: 4933434I06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71233
Homologene: 17022
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Tmem208
Name: transmembrane protein 208
Synonyms: Hspc171, 2610030K20Rik, 1700006C06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66320
Homologene: 40930
Aox3
Name: aldehyde oxidase 3
Synonyms: 1200011D03Rik, AOH1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71724
Homologene: 90899
Klhl32
Name: kelch-like 32
Synonyms: D4Ertd389e, LOC384000, 6430524H05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212390
Homologene: 14173
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Cyp2c39
Name: cytochrome P450, family 2, subfamily c, polypeptide 39
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13098
Homologene: 117948
Or4c111
Name: olfactory receptor family 4 subfamily C member 111
Synonyms: MOR233-9, Olfr1216, GA_x6K02T2Q125-50494588-50493653
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258895
Homologene: 74241
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: TCF-11, NRF1, TCF11, Lcrf1, LCR-F1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Capn9
Name: calpain 9
Synonyms: nCL-4, GC36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73647
HGNC: HGNC:1486
Homologene: 38208
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Elmo1
Name: engulfment and cell motility 1
Synonyms: C230095H21Rik, 6330578D22Rik, CED-12
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
Pcdhb17
Name: protocadherin beta 17
Synonyms: PcdhbQ, Pcdhb16
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93888
Homologene: 81881
Hycc2
Name: hyccin PI4KA lipid kinase complex subunit 2
Synonyms: Fam126b, D1Ertd53e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213056
Homologene: 18184
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: Lppr3, BC005764
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216152
Homologene: 11769
Slc38a8
Name: solute carrier family 38, member 8
Synonyms: LOC234788
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234788
Homologene: 19028
Ccdc153
Name: coiled-coil domain containing 153
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270150
VEGA: 9
Homologene: 26818
Runx3
Name: runt related transcription factor 3
Synonyms: AML2, Rx3, Cbfa3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12399
Homologene: 37914
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73246
Homologene: 37125
Crisp3
Name: cysteine-rich secretory protein 3
Synonyms: Aeg2, CRISP-3, SGP28, CRS3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11572
Homologene: 135665
Rslcan18
Name: regulator of sex-limitation candidate 18
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432770
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 58,176,510 bp (GRCm38)
  • A to G, chromosome 1 at 58,535,482 bp (GRCm38)
  • T to C, chromosome 1 at 106,380,349 bp (GRCm38)
  • T to C, chromosome 2 at 21,196,779 bp (GRCm38)
  • T to G, chromosome 2 at 35,292,729 bp (GRCm38)
  • T to C, chromosome 2 at 48,905,551 bp (GRCm38)
  • T to A, chromosome 2 at 82,986,941 bp (GRCm38)
  • A to C, chromosome 2 at 89,013,173 bp (GRCm38)
  • A to C, chromosome 3 at 9,278,295 bp (GRCm38)
  • A to G, chromosome 4 at 24,629,273 bp (GRCm38)
  • A to G, chromosome 4 at 106,403,931 bp (GRCm38)
  • A to G, chromosome 4 at 135,171,130 bp (GRCm38)
  • G to A, chromosome 4 at 154,249,453 bp (GRCm38)
  • A to G, chromosome 4 at 156,170,384 bp (GRCm38)
  • A to C, chromosome 5 at 20,908,121 bp (GRCm38)
  • A to T, chromosome 5 at 90,617,713 bp (GRCm38)
  • G to T, chromosome 5 at 109,220,096 bp (GRCm38)
  • T to A, chromosome 7 at 56,164,095 bp (GRCm38)
  • A to G, chromosome 7 at 110,371,591 bp (GRCm38)
  • A to G, chromosome 7 at 126,861,955 bp (GRCm38)
  • T to G, chromosome 8 at 24,637,232 bp (GRCm38)
  • G to A, chromosome 8 at 40,826,314 bp (GRCm38)
  • T to A, chromosome 8 at 94,173,371 bp (GRCm38)
  • T to C, chromosome 8 at 105,328,395 bp (GRCm38)
  • A to T, chromosome 8 at 106,653,616 bp (GRCm38)
  • T to A, chromosome 8 at 119,501,149 bp (GRCm38)
  • T to C, chromosome 8 at 124,598,795 bp (GRCm38)
  • A to T, chromosome 9 at 44,243,626 bp (GRCm38)
  • C to A, chromosome 9 at 44,822,156 bp (GRCm38)
  • T to C, chromosome 10 at 9,843,357 bp (GRCm38)
  • T to C, chromosome 10 at 79,866,877 bp (GRCm38)
  • T to G, chromosome 10 at 128,112,755 bp (GRCm38)
  • T to C, chromosome 11 at 59,003,669 bp (GRCm38)
  • T to C, chromosome 11 at 86,242,998 bp (GRCm38)
  • A to G, chromosome 11 at 96,819,333 bp (GRCm38)
  • A to G, chromosome 11 at 100,705,371 bp (GRCm38)
  • C to T, chromosome 13 at 20,286,727 bp (GRCm38)
  • T to C, chromosome 13 at 67,112,232 bp (GRCm38)
  • A to C, chromosome 13 at 104,111,173 bp (GRCm38)
  • T to C, chromosome 14 at 63,141,737 bp (GRCm38)
  • T to A, chromosome 15 at 82,029,127 bp (GRCm38)
  • T to C, chromosome 16 at 45,680,689 bp (GRCm38)
  • G to A, chromosome 17 at 27,118,677 bp (GRCm38)
  • A to T, chromosome 17 at 40,228,785 bp (GRCm38)
  • T to C, chromosome 17 at 74,374,148 bp (GRCm38)
  • T to A, chromosome 17 at 79,681,667 bp (GRCm38)
  • C to A, chromosome 18 at 37,485,866 bp (GRCm38)
  • A to T, chromosome 18 at 65,623,553 bp (GRCm38)
  • G to T, chromosome 19 at 39,513,599 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9472 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069275-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.