Strain Name:
C57BL/6J-MtgxR9478Btlr/Mmmh
Stock Number:
069281-MU
Citation ID:
RRID:MMRRC_069281-MU
Other Names:
R9478 (G1)
Major Collection:

Strain Information

Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20349
Homologene: 8247
Vps41
Name: VPS41 HOPS complex subunit
Synonyms: Vam2, mVam2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218035
VEGA: 13
Homologene: 69165
Pank4
Name: pantothenate kinase 4
Synonyms: D030031I12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269614
Homologene: 41235
Hgf
Name: hepatocyte growth factor
Synonyms: NK2, SF/HGF, HGF/SF, C230052L06Rik, scatter factor, NK1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: ZMYND8, 2010005I16Rik, 1110013E22Rik, 3632413B07Rik, RACK7, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms: 2410004I17Rik, D030072L07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71988
Homologene: 12432
Dock1
Name: dedicator of cytokinesis 1
Synonyms: 9130006G06Rik, Dock180, D630004B07Rik, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTP-H1, PTPCL, 9530011I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Tgds
Name: TDP-glucose 4,6-dehydratase
Synonyms: 2610025M23Rik, 2610017J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76355
VEGA: 14
Homologene: 129708
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, A330064G03Rik, HELIC2, Ascc3l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Atg14
Name: autophagy related 14
Synonyms: D14Ertd114e, Barkor, D14Ertd436e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504663
VEGA: 14
Homologene: 45423
Kif1b
Name: kinesin family member 1B
Synonyms: A530096N05Rik, KIF1Bp130, KIF1Bp204, N-3 kinesin, D4Mil1e, Kif1b alpha, Kif1b beta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Sumo1
Name: small ubiquitin-like modifier 1
Synonyms: Ubl1, Smt3C, PIC1, SENTRIN
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22218
Homologene: 2514
Klhl24
Name: kelch-like 24
Synonyms: 4930429H24Rik, 1110046J11Rik, 6530402O20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75785
VEGA: 16
Homologene: 32352
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, dynein heavy chain, retrograde transport, Dnchc1, Swl, MAP1C, 9930018I23Rik, Dnec1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Epha8
Name: Eph receptor A8
Synonyms: Eek, EphA8, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Ncbp3
Name: nuclear cap binding subunit 3
Synonyms: 1200014J11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66874
Homologene: 10231
Csf2rb2
Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
Synonyms: Il3rb2, BetaIl3, Bil3, Il3r, AIC2A
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12984
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Sfrp4
Name: secreted frizzled-related protein 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20379
VEGA: 13
Homologene: 2267
Arih2
Name: ariadne RBR E3 ubiquitin protein ligase 2
Synonyms: TRIAD1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23807
HGNC: HGNC:690
Homologene: 48424
Oit3
Name: oncoprotein induced transcript 3
Synonyms: EF-9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18302
Homologene: 7870
Abcf2
Name: ATP-binding cassette, sub-family F member 2
Synonyms: Drr3, 0710005O05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27407
Homologene: 21408
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Atmin
Name: ATM interactor
Synonyms: gpg6, Asciz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234776
Homologene: 35321
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Tcp10a
Name: t-complex protein 10a
Synonyms: Gm10326, D17Leh66A, Tcp-10a, T66A-a, D17Leh66aa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21461
Homologene: 83254
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Dcdc3, mG145, oxygen-regulated protein 1, Orp1, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Il17ra
Name: interleukin 17 receptor A
Synonyms: VDw217, Il17r
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: Olfr743-ps1, Olfr265, MOR106-8P, MOR106-14, GA_x6K02T2PMLR-6243196-6244132, GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, Olfr264, Olfr743
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219019
Homologene: 74163
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Or5p52
Name: olfactory receptor family 5 subfamily P member 52
Synonyms: MOR204-5, GA_x6K02T2PBJ9-10231953-10232885, Olfr472
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258770
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, LOC383304, 1700013J13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms: Spi2/eb.4, alpha-1 antiproteinase, Spi2-2, Spi2.2, antitrypsin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20716
HGNC: HGNC:16
Homologene: 111129
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
3100002H09Rik
Name: RIKEN cDNA 3100002H09 gene
Type: Gene
Species: Mouse
Chromosome: 4
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75453
Homologene: 49919
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338349
Homologene: 9805
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Cfap119
Name: cilia and flagella associated protein 119
Synonyms: Ccdc189, LOC233899, Gm166
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233899
Homologene: 79950
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: Catsperg, A230107C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320225
Homologene: 10915
Krt83
Name: keratin 83
Synonyms: 5430421N21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100126226
Homologene: 68248
Lztfl1
Name: leucine zipper transcription factor-like 1
Synonyms: 6130400H19Rik, 5530402H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93730
HGNC: HGNC:6741
Homologene: 41368
Or6c6
Name: olfactory receptor family 6 subfamily C member 6
Synonyms: GA_x6K02T2PULF-11031172-11032116, MOR110-8, Olfr782
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257985
Homologene: 133581
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Mfsd9
Name: major facilitator superfamily domain containing 9
Synonyms: 4931419K03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211798
Homologene: 13100
Or4b1
Name: olfactory receptor family 4 subfamily B member 1
Synonyms: Olfr1270, MOR227-1, GA_x6K02T2Q125-51584440-51583526
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258987
HGNC: HGNC:8290
Homologene: 133648
Purb
Name: purine rich element binding protein B
Synonyms: Cager-2, D11Bwg0414e, 2310015K15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19291
HGNC: HGNC:9702
Homologene: 69087
Poglut3
Name: protein O-glucosyltransferase 3
Synonyms: 4833410J10Rik, Kdelc2, 2010004J24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68304
VEGA: 9
Homologene: 17805
Mab21l3
Name: mab-21-like 3
Synonyms: BC037703
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242125
Homologene: 17564
Sertad3
Name: SERTA domain containing 3
Synonyms: Rbt1, Sei3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 170742
Homologene: 8361
Rcor2
Name: REST corepressor 2
Synonyms: 1A13, CoREST
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104383
Homologene: 14280
Slc35a5
Name: solute carrier family 35, member A5
Synonyms: D730043G07Rik, D16Ertd450e, 1010001J06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74102
Homologene: 9930
Trav7d-3
Name: T cell receptor alpha variable 7D-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042419
Gale
Name: galactose-4-epimerase, UDP
Synonyms: 2310002A12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74246
HGNC: HGNC:4116
Homologene: 347
Inha
Name: inhibin alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16322
HGNC: HGNC:6065
Homologene: 1652
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 4,347,322 bp (GRCm38)
  • T to C, chromosome 1 at 40,773,781 bp (GRCm38)
  • A to G, chromosome 1 at 59,655,456 bp (GRCm38)
  • A to G, chromosome 1 at 75,509,918 bp (GRCm38)
  • T to A, chromosome 2 at 52,188,776 bp (GRCm38)
  • T to C, chromosome 2 at 66,326,149 bp (GRCm38)
  • C to A, chromosome 2 at 90,149,251 bp (GRCm38)
  • G to A, chromosome 2 at 127,235,073 bp (GRCm38)
  • C to A, chromosome 2 at 165,807,649 bp (GRCm38)
  • T to A, chromosome 3 at 63,699,404 bp (GRCm38)
  • A to T, chromosome 3 at 101,818,671 bp (GRCm38)
  • A to T, chromosome 4 at 57,197,573 bp (GRCm38)
  • G to A, chromosome 4 at 84,979,393 bp (GRCm38)
  • A to G, chromosome 4 at 124,610,358 bp (GRCm38)
  • C to T, chromosome 4 at 135,965,263 bp (GRCm38)
  • G to T, chromosome 4 at 136,938,586 bp (GRCm38)
  • C to T, chromosome 4 at 149,261,159 bp (GRCm38)
  • G to A, chromosome 4 at 154,980,108 bp (GRCm38)
  • T to C, chromosome 5 at 14,236,372 bp (GRCm38)
  • A to G, chromosome 5 at 16,561,031 bp (GRCm38)
  • A to G, chromosome 5 at 24,565,942 bp (GRCm38)
  • T to A, chromosome 5 at 146,098,187 bp (GRCm38)
  • A to G, chromosome 6 at 120,474,375 bp (GRCm38)
  • T to C, chromosome 7 at 27,476,254 bp (GRCm38)
  • G to T, chromosome 7 at 29,198,352 bp (GRCm38)
  • G to A, chromosome 7 at 107,903,031 bp (GRCm38)
  • T to C, chromosome 7 at 127,584,915 bp (GRCm38)
  • T to A, chromosome 7 at 134,766,233 bp (GRCm38)
  • C to T, chromosome 8 at 116,954,798 bp (GRCm38)
  • C to T, chromosome 8 at 129,110,992 bp (GRCm38)
  • T to C, chromosome 9 at 53,391,936 bp (GRCm38)
  • C to G, chromosome 9 at 108,611,739 bp (GRCm38)
  • T to C, chromosome 9 at 123,708,102 bp (GRCm38)
  • T to A, chromosome 10 at 27,015,482 bp (GRCm38)
  • T to G, chromosome 10 at 53,348,779 bp (GRCm38)
  • C to A, chromosome 10 at 59,438,642 bp (GRCm38)
  • T to A, chromosome 10 at 129,351,091 bp (GRCm38)
  • A to G, chromosome 11 at 6,475,424 bp (GRCm38)
  • A to G, chromosome 11 at 73,077,942 bp (GRCm38)
  • A to G, chromosome 12 at 76,107,613 bp (GRCm38)
  • A to T, chromosome 12 at 104,412,413 bp (GRCm38)
  • T to C, chromosome 12 at 110,658,703 bp (GRCm38)
  • A to G, chromosome 13 at 18,862,743 bp (GRCm38)
  • G to T, chromosome 13 at 19,623,440 bp (GRCm38)
  • A to T, chromosome 13 at 77,303,454 bp (GRCm38)
  • G to A, chromosome 14 at 35,321,707 bp (GRCm38)
  • G to T, chromosome 14 at 47,545,681 bp (GRCm38)
  • A to T, chromosome 14 at 50,533,594 bp (GRCm38)
  • A to T, chromosome 14 at 52,744,597 bp (GRCm38)
  • C to A, chromosome 14 at 65,831,208 bp (GRCm38)
  • T to C, chromosome 14 at 118,115,132 bp (GRCm38)
  • T to C, chromosome 15 at 34,345,096 bp (GRCm38)
  • C to A, chromosome 15 at 78,284,765 bp (GRCm38)
  • G to A, chromosome 15 at 101,487,568 bp (GRCm38)
  • T to G, chromosome 16 at 20,123,013 bp (GRCm38)
  • T to C, chromosome 16 at 45,144,063 bp (GRCm38)
  • A to T, chromosome 17 at 7,334,341 bp (GRCm38)
  • G to A, chromosome 18 at 13,817,315 bp (GRCm38)
  • A to T, chromosome 18 at 20,397,951 bp (GRCm38)
  • G to A, chromosome 18 at 22,920,877 bp (GRCm38)
  • C to T, chromosome 19 at 7,271,429 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9478 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069281-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.