Strain Name:
C57BL/6J-MtgxR9506Btlr/Mmmh
Stock Number:
069309-MU
Citation ID:
RRID:MMRRC_069309-MU
Other Names:
R9506 (G1)
Major Collection:

Strain Information

Vcp
Name: valosin containing protein
Synonyms: AAA ATPase p97, CDC48, p97, p97/VCP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269523
Homologene: 5168
Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, OTTMUSG00000012483, C030040A15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109241
Homologene: 81861
Chrna9
Name: cholinergic receptor, nicotinic, alpha polypeptide 9
Synonyms: Gm8311, 2410015I05Rik, Acra9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231252
Homologene: 9729
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215303
Homologene: 48706
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Hsf2
Name: heat shock factor 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15500
VEGA: 10
HGNC: HGNC:5225
Homologene: 37931
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: Rab11-FIP3, D030060O14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215445
Homologene: 49396
Txnrd3
Name: thioredoxin reductase 3
Synonyms: Tgr, TR2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232223
Homologene: 60033
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: 2810036I15Rik, Syt3-rs, RIM2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: PMCA1, E130111D10Rik, 2810442I22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Ermard
Name: ER membrane associated RNA degradation
Synonyms: 2210404J11Rik, 2410011O22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381062
Homologene: 19936
Jup
Name: junction plakoglobin
Synonyms: PG, plakoglobin, D930025P04Rik, Ctnng, gamma-catenin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16480
HGNC: HGNC:6207
Homologene: 1680
Nxf1
Name: nuclear RNA export factor 1
Synonyms: Mex67, Mvb1, TAP, Tip associated protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 53319
HGNC: HGNC:8071
Homologene: 38176
Ube3d
Name: ubiquitin protein ligase E3D
Synonyms: Ube2cbp, 2610018I03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70348
Homologene: 18898
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Rap1gap2
Name: RAP1 GTPase activating protein 2
Synonyms: Garnl4, LOC380710
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380711
Homologene: 56695
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: HL-19, Dnahc7l, DHC3, Dnahc12, HL19, LOC380889, Hdhc3, 4921531P07Rik, DLP12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: A630082K20Rik, ENSMUSG00000073143, Jhdm1d, Kdm7a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 338523
Homologene: 25281
Cmpk2
Name: cytidine/uridine monophosphate kinase 2
Synonyms: TDKI, Tyki, 1200004E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22169
VEGA: 12
Homologene: 10748
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627743
Homologene: 129680
Kynu
Name: kynureninase
Synonyms: 4432411A05Rik, L-kynurenine hydrolase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70789
HGNC: HGNC:6469
Homologene: 2925
Nup210
Name: nucleoporin 210
Synonyms: gp190, gp210, Pom210
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54563
Homologene: 41286
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545934
Homologene: 79577
Wnt7b
Name: wingless-type MMTV integration site family, member 7B
Synonyms: Wnt-7b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22422
VEGA: 15
Homologene: 22531
Gsta3
Name: glutathione S-transferase, alpha 3
Synonyms: Gst2-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14859
Homologene: 37355
Tas2r131
Name: taste receptor, type 2, member 131
Synonyms: T2R31, Tas2r31, mGR31, mt2r61
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387356
Homologene: 52298
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230612
Homologene: 17081
Or4a67
Name: olfactory receptor family 4 subfamily A member 67
Synonyms: GA_x6K02T2Q125-50243231-50242221, MOR225-12, Olfr1200
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257887
Homologene: 123770
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: D930038M13Rik, TARSH, 5033411B22Rik, eratin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Tigd3
Name: tigger transposable element derived 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 332359
VEGA: 19
Homologene: 129795
Fstl4
Name: follistatin-like 4
Synonyms: B230374F23Rik, SPIG1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
Best3
Name: bestrophin 3
Synonyms: Vmd2l3, mBest4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382427
VEGA: 10
Homologene: 33850
H4c3
Name: H4 clustered histone 3
Synonyms: Hist1h4c
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319155
Homologene: 136776
Vmn1r234
Name: vomeronasal 1 receptor 234
Synonyms: V1rf1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171232
Slc36a3
Name: solute carrier family 36 (proton/amino acid symporter), member 3
Synonyms: PAT3, TRAMD2, tramdorin2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215332
Homologene: 76175
Mknk2
Name: MAP kinase-interacting serine/threonine kinase 2
Synonyms: Mnk2, 2010016G11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17347
HGNC: HGNC:7111
Homologene: 49674
Cutal
Name: cutA divalent cation tolerance homolog-like
Synonyms: D730039F16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77996
Homologene: 66286
Zfp850
Name: zinc finger protein 850
Synonyms: Gm4636, C130069I09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043772
Elovl1
Name: ELOVL fatty acid elongase 1
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1, Ssc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54325
Homologene: 41322
Mtfmt
Name: mitochondrial methionyl-tRNA formyltransferase
Synonyms: 2310020P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69606
Homologene: 12320
Glrx2
Name: glutaredoxin 2
Synonyms: 1700010P22Rik, thioltransferase, Grx2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69367
Homologene: 41098
Cflar
Name: CASP8 and FADD-like apoptosis regulator
Synonyms: Cash, c-Flip, Flip, 2310024N18Rik, A430105C05Rik, Casper
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12633
HGNC: HGNC:1876
Homologene: 7652
Ilk
Name: integrin linked kinase
Synonyms: ESTM24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16202
HGNC: HGNC:6040
Homologene: 3318
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to C, chromosome 1 at 21,257,362 bp (GRCm38)
  • A to T, chromosome 1 at 58,752,816 bp (GRCm38)
  • C to T, chromosome 1 at 143,746,532 bp (GRCm38)
  • A to G, chromosome 1 at 173,923,999 bp (GRCm38)
  • A to G, chromosome 1 at 193,348,055 bp (GRCm38)
  • A to T, chromosome 2 at 26,429,372 bp (GRCm38)
  • A to G, chromosome 2 at 34,885,882 bp (GRCm38)
  • T to A, chromosome 2 at 43,681,402 bp (GRCm38)
  • T to C, chromosome 2 at 49,272,907 bp (GRCm38)
  • T to C, chromosome 2 at 88,767,496 bp (GRCm38)
  • A to G, chromosome 4 at 42,983,383 bp (GRCm38)
  • G to A, chromosome 4 at 111,893,242 bp (GRCm38)
  • A to G, chromosome 4 at 118,430,715 bp (GRCm38)
  • T to A, chromosome 5 at 65,970,870 bp (GRCm38)
  • C to T, chromosome 5 at 70,782,370 bp (GRCm38)
  • T to A, chromosome 6 at 39,149,371 bp (GRCm38)
  • A to G, chromosome 6 at 73,142,316 bp (GRCm38)
  • A to G, chromosome 6 at 89,661,479 bp (GRCm38)
  • G to A, chromosome 6 at 91,071,874 bp (GRCm38)
  • T to A, chromosome 6 at 132,957,061 bp (GRCm38)
  • T to A, chromosome 7 at 23,702,538 bp (GRCm38)
  • C to A, chromosome 7 at 27,989,562 bp (GRCm38)
  • T to C, chromosome 7 at 105,740,813 bp (GRCm38)
  • A to G, chromosome 8 at 16,200,009 bp (GRCm38)
  • C to T, chromosome 9 at 65,435,865 bp (GRCm38)
  • A to G, chromosome 9 at 86,448,772 bp (GRCm38)
  • G to A, chromosome 10 at 57,505,145 bp (GRCm38)
  • T to C, chromosome 10 at 80,668,084 bp (GRCm38)
  • T to C, chromosome 10 at 99,023,000 bp (GRCm38)
  • T to A, chromosome 10 at 117,003,921 bp (GRCm38)
  • A to G, chromosome 11 at 53,134,123 bp (GRCm38)
  • A to G, chromosome 11 at 55,148,631 bp (GRCm38)
  • A to G, chromosome 11 at 74,414,440 bp (GRCm38)
  • G to A, chromosome 11 at 100,376,878 bp (GRCm38)
  • A to G, chromosome 12 at 26,469,851 bp (GRCm38)
  • G to A, chromosome 12 at 111,294,938 bp (GRCm38)
  • C to T, chromosome 13 at 23,698,281 bp (GRCm38)
  • G to T, chromosome 14 at 26,792,211 bp (GRCm38)
  • G to A, chromosome 15 at 39,472,436 bp (GRCm38)
  • A to G, chromosome 15 at 85,581,412 bp (GRCm38)
  • A to G, chromosome 16 at 56,617,410 bp (GRCm38)
  • T to A, chromosome 17 at 15,061,106 bp (GRCm38)
  • C to T, chromosome 17 at 20,209,142 bp (GRCm38)
  • T to G, chromosome 17 at 21,229,241 bp (GRCm38)
  • T to G, chromosome 17 at 25,994,276 bp (GRCm38)
  • A to G, chromosome 18 at 74,744,760 bp (GRCm38)
  • G to T, chromosome 19 at 5,892,832 bp (GRCm38)
  • A to G, chromosome 19 at 8,772,144 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9506 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069309-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.