Strain Name:
C57BL/6J-MtgxR9519Btlr/Mmmh
Stock Number:
069321-MU
Citation ID:
RRID:MMRRC_069321-MU
Other Names:
R9519 (G1)
Major Collection:

Strain Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1-D, NFATp, NFAT1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: D630035I23Rik, TRIP8, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Smg7
Name: SMG7 nonsense mediated mRNA decay factor
Synonyms: Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), 9430023P16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226517
Homologene: 32235
Snrnp70
Name: small nuclear ribonucleoprotein 70 (U1)
Synonyms: U1-70, Srnp70, Rnulp70, Snrp70, 2700022N21Rik, 3200002N22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20637
Homologene: 20672
Arid2
Name: AT-rich interaction domain 2
Synonyms: zipzap/p200, 1700124K17Rik, 4432409D24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77044
Homologene: 14601
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Prom1
Name: prominin 1
Synonyms: AC133, Prom-1, CD133, 4932416E19Rik, Prom
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
Soat1
Name: sterol O-acyltransferase 1
Synonyms: ACAT-1, Acact, hid, 8430426K15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20652
Homologene: 2333
Smarce1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms: 9030408N19Rik, 2810417B20Rik, BAF57, 5830412H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57376
Homologene: 37727
Peg3
Name: paternally expressed 3
Synonyms: Zfp102, End4, Gcap4, Pw1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Far1
Name: fatty acyl CoA reductase 1
Synonyms: 2900034E22Rik, 2600011M19Rik, Mlstd2, 3732409C05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67420
Homologene: 41718
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, Gm21044, LOC385009
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69710
Homologene: 12326
Golm1
Name: golgi membrane protein 1
Synonyms: Golph2, GP73, PSEC0257, D030064E01Rik, 2310001L02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Inpp5f
Name: inositol polyphosphate-5-phosphatase F
Synonyms: SAC2, 5830435P03Rik, cI-27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101490
Homologene: 8962
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: Pdgfr-2, CD140a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, Slc9a10, spermNHE
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Hek, Hek4, Mek4, End3, Cek4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Kcnn4
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Synonyms: IK1, mIKCa1, SK4, IKCa1, KCa3.1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16534
HGNC: HGNC:6293
Homologene: 1696
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, b2b1000Clo, LTBP-1, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp-zeta, Nalp9c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Zfp790
Name: zinc finger protein 790
Synonyms: 6330581L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233056
Homologene: 51695
Dll3
Name: delta like canonical Notch ligand 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13389
HGNC: HGNC:2909
Homologene: 7291
Lipm
Name: lipase, family member M
Synonyms: 4632427C23Rik, Lipl3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78753
VEGA: 19
Homologene: 28267
Kif9
Name: kinesin family member 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16578
Homologene: 65620
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Snx25
Name: sorting nexin 25
Synonyms: LOC382008, SBBI31
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102141
Homologene: 23744
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110893
Homologene: 62645
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381260
Homologene: 124277
Speg
Name: SPEG complex locus
Synonyms: SPEGalpha, SPEG, D1Bwg1450e, Apeg1, SPEGbeta, BPEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Sult1d1
Name: sulfotransferase family 1D, member 1
Synonyms: tyrosine-ester sulfotransferase, Sultn, 5033411P13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53315
Homologene: 124464
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mdrap, MRP, Mrp1, Abcc1a, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: mABH2, Abh2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231642
Homologene: 18393
Or51a10
Name: olfactory receptor family 51 subfamily A member 10
Synonyms: GA_x6K02T2PBJ9-6784380-6783436, MOR13-6, Olfr642
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258326
Homologene: 17196
Atxn1l
Name: ataxin 1-like
Synonyms: D8Ertd587e, C330011L24Rik, ENSMUSG00000069895, Boat
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52335
Homologene: 19471
Ms4a13
Name: membrane-spanning 4-domains, subfamily A, member 13
Synonyms: 1700060E18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73466
Homologene: 77851
Parp16
Name: poly (ADP-ribose) polymerase family, member 16
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214424
VEGA: 9
Homologene: 9878
Snx20
Name: sorting nexin 20
Synonyms: 9130017C17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71607
Homologene: 12399
Flot1
Name: flotillin 1
Synonyms: reggie-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14251
HGNC: HGNC:3757
Homologene: 31337
Stoml3
Name: stomatin (Epb7.2)-like 3
Synonyms: SRO, SLP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229277
Homologene: 16628
Gpr85
Name: G protein-coupled receptor 85
Synonyms: 2900026B03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64450
HGNC: HGNC:4536
Homologene: 10355
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: WARP, 4932416A11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246228
Homologene: 11270
Sds
Name: serine dehydratase
Synonyms: SDH
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231691
Homologene: 38235
Or1p1b
Name: olfactory receptor family 1 subfamily P member 1B
Synonyms: MOR133-5P, Olfr404-ps1, GA_x6K02T2P1NL-4385196-4386167
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257920
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to C, chromosome 1 at 58,334,767 bp (GRCm38)
  • A to G, chromosome 1 at 59,541,452 bp (GRCm38)
  • C to T, chromosome 1 at 75,415,736 bp (GRCm38)
  • G to T, chromosome 1 at 152,859,445 bp (GRCm38)
  • T to C, chromosome 1 at 156,432,209 bp (GRCm38)
  • T to C, chromosome 2 at 168,570,758 bp (GRCm38)
  • T to A, chromosome 3 at 53,497,981 bp (GRCm38)
  • C to G, chromosome 3 at 87,995,657 bp (GRCm38)
  • C to A, chromosome 3 at 87,995,660 bp (GRCm38)
  • T to C, chromosome 3 at 87,995,661 bp (GRCm38)
  • G to A, chromosome 4 at 155,772,879 bp (GRCm38)
  • A to G, chromosome 5 at 44,056,061 bp (GRCm38)
  • A to T, chromosome 5 at 75,176,689 bp (GRCm38)
  • T to C, chromosome 5 at 76,882,725 bp (GRCm38)
  • A to T, chromosome 5 at 87,556,862 bp (GRCm38)
  • T to C, chromosome 5 at 114,127,733 bp (GRCm38)
  • T to A, chromosome 5 at 120,481,545 bp (GRCm38)
  • T to C, chromosome 6 at 13,836,999 bp (GRCm38)
  • T to C, chromosome 7 at 6,711,395 bp (GRCm38)
  • T to A, chromosome 7 at 24,382,516 bp (GRCm38)
  • T to A, chromosome 7 at 26,385,877 bp (GRCm38)
  • A to G, chromosome 7 at 28,296,339 bp (GRCm38)
  • C to A, chromosome 7 at 29,823,142 bp (GRCm38)
  • G to A, chromosome 7 at 44,312,918 bp (GRCm38)
  • C to T, chromosome 7 at 45,387,451 bp (GRCm38)
  • G to GACGGCGGCC, chromosome 7 at 97,579,909 bp (GRCm38)
  • G to A, chromosome 7 at 101,394,739 bp (GRCm38)
  • C to A, chromosome 7 at 104,049,429 bp (GRCm38)
  • A to G, chromosome 7 at 113,551,352 bp (GRCm38)
  • A to C, chromosome 7 at 128,676,791 bp (GRCm38)
  • A to G, chromosome 8 at 46,033,746 bp (GRCm38)
  • A to G, chromosome 8 at 88,627,772 bp (GRCm38)
  • C to T, chromosome 8 at 109,732,056 bp (GRCm38)
  • A to T, chromosome 9 at 18,586,920 bp (GRCm38)
  • T to A, chromosome 9 at 65,229,940 bp (GRCm38)
  • A to G, chromosome 9 at 66,400,074 bp (GRCm38)
  • A to G, chromosome 9 at 110,521,276 bp (GRCm38)
  • A to G, chromosome 10 at 67,158,019 bp (GRCm38)
  • T to C, chromosome 10 at 107,685,100 bp (GRCm38)
  • A to T, chromosome 11 at 74,240,001 bp (GRCm38)
  • A to G, chromosome 11 at 94,373,979 bp (GRCm38)
  • A to T, chromosome 11 at 99,214,107 bp (GRCm38)
  • G to A, chromosome 11 at 120,021,483 bp (GRCm38)
  • A to T, chromosome 12 at 81,315,552 bp (GRCm38)
  • T to C, chromosome 13 at 59,645,100 bp (GRCm38)
  • T to C, chromosome 14 at 12,546,290 bp (GRCm38)
  • A to G, chromosome 15 at 96,289,067 bp (GRCm38)
  • T to C, chromosome 16 at 14,389,817 bp (GRCm38)
  • A to T, chromosome 16 at 45,575,407 bp (GRCm38)
  • T to A, chromosome 16 at 63,652,305 bp (GRCm38)
  • T to C, chromosome 16 at 89,811,934 bp (GRCm38)
  • T to G, chromosome 17 at 35,825,471 bp (GRCm38)
  • C to T, chromosome 17 at 75,385,195 bp (GRCm38)
  • C to G, chromosome 19 at 11,169,968 bp (GRCm38)
  • T to C, chromosome 19 at 34,112,992 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9519 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069321-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.