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Strain Name:
C57BL/6J-MtgxR9525Btlr/Mmmh
Stock Number:
069326-MU
Citation ID:
RRID:MMRRC_069326-MU
Other Names:
R9525 (G1)
Major Collection:

Strain Information

Cbx7
Name: chromobox 7
Synonyms: 1600014J01Rik, D15Ertd417e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52609
HGNC: HGNC:1557
Homologene: 65296
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: p70/85s6k, p70s6k, S6K1, 2610318I15Rik, p70S6K1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Emc8
Name: ER membrane protein complex subunit 8
Synonyms: Noc4, Fam158b, Cox4nb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18117
HGNC: HGNC:7864
Homologene: 4424
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: WOX1, 9030416C10Rik, 5330426P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80707
Homologene: 56334
Clasp2
Name: CLIP associating protein 2
Synonyms: 1500004F14Rik, CLASP2gamma, CLASP2beta, CLASP2alpha, CLASP2, 8030404L10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76499
VEGA: 9
Homologene: 24944
Anapc2
Name: anaphase promoting complex subunit 2
Synonyms: expressed during mesenchymal induction 4, Emi4, APC2, 9230107K09Rik, Imi4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99152
Homologene: 8359
Tbck
Name: TBC1 domain containing kinase
Synonyms: A630047E20Rik, 1700120J03Rik, C030007I09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271981
Homologene: 13221
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: PRO2405, 9530003A05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227634
Homologene: 19202
Trhr
Name: thyrotropin releasing hormone receptor
Synonyms: TRH-R1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22045
VEGA: 15
Homologene: 20707
Fnbp1l
Name: formin binding protein 1-like
Synonyms: TOCA1, 2610318I01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214459
Homologene: 134636
Iqcd
Name: IQ motif containing D
Synonyms: 4933433C09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75732
Homologene: 49921
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Timp2
Name: tissue inhibitor of metalloproteinase 2
Synonyms: TIMP-2, Timp-2, D11Bwg1104e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21858
Homologene: 2444
Cd274
Name: CD274 antigen
Synonyms: B7-H1, PD-L1, Pdcd1lg1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 60533
Homologene: 8560
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233552
Homologene: 32741
Hepacam2
Name: HEPACAM family member 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101202
Homologene: 18724
Tomm40
Name: translocase of outer mitochondrial membrane 40
Synonyms: Tom40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53333
Homologene: 101105
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: crn, 1200013P10Rik, 5730590A01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66877
Homologene: 6462
Pot1a
Name: protection of telomeres 1A
Synonyms: 1500031H18Rik, Pot1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101185
Homologene: 32263
Xxylt1
Name: xyloside xylosyltransferase 1
Synonyms: AI480653
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268880
Homologene: 17610
Pcdhb18
Name: protocadherin beta 18
Synonyms: Pcdhb9, PcdhbR
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93889
Homologene: 137649
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: NMDAR1, NR1, Nmdar, M100174, GluRzeta1, Rgsc174
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Fgd2
Name: FYVE, RhoGEF and PH domain containing 2
Synonyms: tcs-2, Tcd-2, tcs2, Tcd2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26382
HGNC: HGNC:3664
Homologene: 8438
Mrm3
Name: mitochondrial rRNA methyltransferase 3
Synonyms: HC90, 4833420N02Rik, Rnmtl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67390
Homologene: 10033
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Trgv5
Name: T cell receptor gamma, variable 5
Synonyms: Tcrg-V5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21639
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Chadl
Name: chondroadherin-like
Synonyms: D930017K21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 214685
Homologene: 130044
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp-gamma, Nalp4b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210045
Homologene: 65242
Ddb2
Name: damage specific DNA binding protein 2
Synonyms: p48, 2610043A19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107986
HGNC: HGNC:2718
Homologene: 83
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545874
Homologene: 135915
Mkrn2
Name: makorin, ring finger protein, 2
Synonyms: 2610002L04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67027
HGNC: HGNC:7113
Homologene: 8392
Aadacl4fm2
Name: AADACL4 family member 2
Synonyms: Gm13124
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627085
Homologene: 135767
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Intin1, Itih-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Gal3st2c
Name: galactose-3-O-sulfotransferase 2C
Synonyms: Gm6086
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619597
Homologene: 41471
Gpr39
Name: G protein-coupled receptor 39
Synonyms: 4933415E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71111
HGNC: HGNC:4496
Homologene: 20380
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Pkp3
Name: plakophilin 3
Synonyms: 2310056L12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56460
HGNC: HGNC:9025
Homologene: 5200
Spmap2l
Name: sperm microtubule associated protein 2 like
Synonyms: 1700023E05Rik, Thegl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71868
Homologene: 128474
Rnf19a
Name: ring finger protein 19A
Synonyms: XYbp, XY body protein, Rnf19, Dorfin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 30945
VEGA: 15
Homologene: 8501
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Tbpl2
Name: TATA box binding protein like 2
Synonyms: LOC227606, Trf3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227606
Homologene: 133152
Epha1
Name: Eph receptor A1
Synonyms: Esk, 5730453L17Rik, Eph
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Or51b6b
Name: olfactory receptor family 51 subfamily B member 6B
Synonyms: GA_x6K02T2PBJ9-6384836-6383883, MOR1-4, Olfr623
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259126
Homologene: 133591
Setdb2
Name: SET domain, bifurcated 2
Synonyms: LOC239122, KMT1F
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Saxo1
Name: stabilizer of axonemal microtubules 1
Synonyms: 4930500O09Rik, Fam154a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75811
Homologene: 27548
Gdf2
Name: growth differentiation factor 2
Synonyms: Bmp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12165
VEGA: 14
HGNC: HGNC:4217
Homologene: 32299
Dbx2
Name: developing brain homeobox 2
Synonyms: LOC383001, 9430056A22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223843
Homologene: 54981
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78895
Homologene: 12842
H2bc15
Name: H2B clustered histone 15
Synonyms: Hist1h2bn
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319187
Homologene: 136772
Or8k20
Name: olfactory receptor family 8 subfamily K member 20
Synonyms: GA_x6K02T2Q125-47756192-47755266, MOR187-5, Olfr1051
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404324
Homologene: 77387
Vmn1r159
Name: vomeronasal 1 receptor 159
Synonyms: Gm16507
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670857
Homologene: 104166
Mylk2
Name: myosin, light polypeptide kinase 2, skeletal muscle
Synonyms: 9830004H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228785
Homologene: 13223
Gpr20
Name: G protein-coupled receptor 20
Synonyms: A430106B11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239530
HGNC: HGNC:4475
Homologene: 3870
Or51i2
Name: olfactory receptor family 51 subfamily I member 2
Synonyms: GA_x6K02T2PBJ9-6773690-6774628, MOR13-3, Olfr641
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259075
Homologene: 17489
Gm8356
Name: predicted gene 8356
Type: Gene
Species: Mouse
Chromosome: 14
Cc2d2b
Name: coiled-coil and C2 domain containing 2B
Synonyms: EG668310
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 668310
Homologene: 141114
Msantd5f3
Name: Myb/SANT DNA binding domain containing 5 family member 3
Synonyms: Gm11238
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100502896
Homologene: 128423
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 94,008,206 bp (GRCm38)
  • T to C, chromosome 1 at 125,872,586 bp (GRCm38)
  • G to T, chromosome 1 at 139,774,512 bp (GRCm38)
  • T to G, chromosome 2 at 24,096,535 bp (GRCm38)
  • T to C, chromosome 2 at 25,276,327 bp (GRCm38)
  • T to C, chromosome 2 at 25,297,460 bp (GRCm38)
  • G to A, chromosome 2 at 25,953,950 bp (GRCm38)
  • A to G, chromosome 2 at 86,276,140 bp (GRCm38)
  • T to G, chromosome 2 at 91,234,835 bp (GRCm38)
  • A to G, chromosome 2 at 145,928,278 bp (GRCm38)
  • T to A, chromosome 2 at 152,917,632 bp (GRCm38)
  • A to T, chromosome 3 at 122,559,054 bp (GRCm38)
  • T to C, chromosome 3 at 132,751,205 bp (GRCm38)
  • G to A, chromosome 4 at 73,654,824 bp (GRCm38)
  • A to T, chromosome 4 at 86,444,949 bp (GRCm38)
  • A to T, chromosome 4 at 118,576,581 bp (GRCm38)
  • T to A, chromosome 4 at 144,555,430 bp (GRCm38)
  • A to G, chromosome 5 at 77,047,291 bp (GRCm38)
  • A to T, chromosome 5 at 109,676,980 bp (GRCm38)
  • T to C, chromosome 5 at 120,600,152 bp (GRCm38)
  • A to G, chromosome 6 at 3,476,046 bp (GRCm38)
  • A to T, chromosome 6 at 25,745,917 bp (GRCm38)
  • A to T, chromosome 6 at 42,367,824 bp (GRCm38)
  • T to A, chromosome 6 at 115,610,525 bp (GRCm38)
  • G to T, chromosome 6 at 123,823,205 bp (GRCm38)
  • A to G, chromosome 7 at 10,714,821 bp (GRCm38)
  • A to G, chromosome 7 at 19,702,887 bp (GRCm38)
  • A to G, chromosome 7 at 22,842,992 bp (GRCm38)
  • A to C, chromosome 7 at 64,372,259 bp (GRCm38)
  • G to A, chromosome 7 at 68,214,934 bp (GRCm38)
  • A to G, chromosome 7 at 99,454,949 bp (GRCm38)
  • A to T, chromosome 7 at 103,660,935 bp (GRCm38)
  • A to G, chromosome 7 at 104,040,613 bp (GRCm38)
  • A to G, chromosome 7 at 141,088,397 bp (GRCm38)
  • T to A, chromosome 8 at 114,706,365 bp (GRCm38)
  • T to C, chromosome 8 at 120,667,917 bp (GRCm38)
  • C to T, chromosome 9 at 95,910,557 bp (GRCm38)
  • T to C, chromosome 9 at 113,911,609 bp (GRCm38)
  • T to A, chromosome 10 at 41,683,226 bp (GRCm38)
  • A to G, chromosome 11 at 76,250,278 bp (GRCm38)
  • C to A, chromosome 11 at 86,519,920 bp (GRCm38)
  • A to C, chromosome 11 at 118,303,852 bp (GRCm38)
  • T to C, chromosome 13 at 19,192,715 bp (GRCm38)
  • G to T, chromosome 13 at 21,754,135 bp (GRCm38)
  • T to C, chromosome 13 at 67,293,428 bp (GRCm38)
  • C to T, chromosome 13 at 81,445,334 bp (GRCm38)
  • G to T, chromosome 13 at 102,736,436 bp (GRCm38)
  • G to T, chromosome 14 at 6,535,192 bp (GRCm38)
  • T to A, chromosome 14 at 7,905,481 bp (GRCm38)
  • T to C, chromosome 14 at 30,936,754 bp (GRCm38)
  • T to C, chromosome 14 at 33,945,607 bp (GRCm38)
  • A to G, chromosome 14 at 33,954,445 bp (GRCm38)
  • T to C, chromosome 14 at 50,891,472 bp (GRCm38)
  • A to T, chromosome 14 at 59,409,392 bp (GRCm38)
  • A to T, chromosome 15 at 36,247,229 bp (GRCm38)
  • T to C, chromosome 15 at 44,197,477 bp (GRCm38)
  • A to T, chromosome 15 at 44,584,926 bp (GRCm38)
  • A to T, chromosome 15 at 73,695,832 bp (GRCm38)
  • A to C, chromosome 15 at 79,930,596 bp (GRCm38)
  • C to A, chromosome 15 at 81,694,019 bp (GRCm38)
  • A to G, chromosome 15 at 94,540,883 bp (GRCm38)
  • G to T, chromosome 15 at 95,654,423 bp (GRCm38)
  • A to G, chromosome 16 at 31,050,775 bp (GRCm38)
  • T to A, chromosome 17 at 29,364,981 bp (GRCm38)
  • T to A, chromosome 18 at 37,491,834 bp (GRCm38)
  • A to G, chromosome 18 at 65,266,217 bp (GRCm38)
  • T to A, chromosome 19 at 29,382,479 bp (GRCm38)
  • T to C, chromosome 19 at 40,784,986 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9525 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069326-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.