Strain Name:
C57BL/6J-MtgxR9536Btlr/Mmmh
Stock Number:
069335-MU
Citation ID:
RRID:MMRRC_069335-MU
Other Names:
R9536 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ank-2, Gm4392, Ankyrin-B, ankyrin B, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd257e, D7Ertd237e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Lars1
Name: leucyl-tRNA synthetase 1
Synonyms: 3110009L02Rik, Lars, 2310045K21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107045
VEGA: 18
HGNC: HGNC:6512
Homologene: 7083
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Gck
Name: glucokinase
Synonyms: MODY2, Hlb62, Gls006, hexokinase 4, HK4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103988
HGNC: HGNC:4195
Homologene: 55440
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LR3, LRP7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
Homologene: 1746
Pcbp3
Name: poly(rC) binding protein 3
Synonyms: AlphaCP-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59093
HGNC: HGNC:8651
Homologene: 23233
Gphn
Name: gephyrin
Synonyms: 5730552E08Rik, geph
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268566
VEGA: 12
Homologene: 10820
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 4932411G06Rik, 1700021E15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, SCP-2, ns-LTP, NSL-TP, nonspecific lipid transfer protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20280
Homologene: 37717
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Arih2
Name: ariadne RBR E3 ubiquitin protein ligase 2
Synonyms: TRIAD1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23807
HGNC: HGNC:690
Homologene: 48424
Drd3
Name: dopamine receptor D3
Synonyms: D3R, D3 receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13490
VEGA: 16
HGNC: HGNC:3024
Homologene: 623
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, A630028O16Rik, LOC380767
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56220
Homologene: 51668
Dennd6a
Name: DENN domain containing 6A
Synonyms: Fam116a, A630054L15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211922
Homologene: 13503
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434179
Homologene: 134004
Rpl5
Name: ribosomal protein L5
Synonyms: Ska23, Skam23Jus, Skax23, U21RNA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503670
Homologene: 110649
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Adamts6
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6
Synonyms: A930019D11Rik, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, ADAM-TS6, b2b2187.1Clo, b2b2228Clo
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108154
VEGA: 13
HGNC: HGNC:222
Homologene: 82573
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
V1rd19
Name: vomeronasal 1 receptor, D19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404287
Homologene: 104166
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 4930431N21Rik, 6530406M24Rik, Ccp3, 2900053G10Rik, Ccp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76223
Homologene: 35330
Gm13941
Name: predicted gene 13941
Type: Gene
Species: Mouse
Chromosome: 2
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: ORP-6, 1110062M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Ubtfl1
Name: upstream binding transcription factor, RNA polymerase I-like 1
Synonyms: B020006M18Rik, Hmgpi
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546118
Homologene: 110115
Cyp26b1
Name: cytochrome P450, family 26, subfamily b, polypeptide 1
Synonyms: CP26, P450RAI-2, retinoic acid B1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232174
Homologene: 23179
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: cI-43, D6Ertd349e, BRAG2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Or52a5b
Name: olfactory receptor family 52 subfamily A member 5B
Synonyms: 3'[b]3, GA_x6K02T2PBJ9-6494485-6493535, Olfr69, MOR22-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18370
Homologene: 128070
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Ccdc62
Name: coiled-coil domain containing 62
Synonyms: LOC208908, G1-485-3, repro29
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208908
Homologene: 82466
Or6c33
Name: olfactory receptor family 6 subfamily C member 33
Synonyms: MOR116-1, Olfr820, GA_x6K02T2PULF-11688441-11689379
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258670
Homologene: 17337
Or2c1
Name: olfactory receptor family 2 subfamily C member 1
Synonyms: Olfr15, GA_x54KRFPKG5P-348087-349025, MOR256-17, OR3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18312
HGNC: HGNC:8242
Homologene: 7459
Gimap9
Name: GTPase, IMAP family member 9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 317758
Homologene: 115637
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70893
Homologene: 72240
Tat
Name: tyrosine aminotransferase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234724
Homologene: 37293
1700013G24Rik
Name: RIKEN cDNA 1700013G24 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69380
Homologene: 124477
Sh2d5
Name: SH2 domain containing 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230863
Homologene: 20002
Chid1
Name: chitinase domain containing 1
Synonyms: 3110023E09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68038
Homologene: 12229
Styxl1
Name: serine/threonine/tyrosine interacting-like 1
Synonyms: Dusp24, 1700011C14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76571
Homologene: 9378
Rps2
Name: ribosomal protein S2
Synonyms: Llrep3, Rps2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16898
Homologene: 37714
Or5p61
Name: olfactory receptor family 5 subfamily P member 61
Synonyms: MOR204-30P, MOR204-40_p, Olfr485, GA_x6K02T2PBJ9-10489044-10488091
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258041
Homologene: 110483
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 2 at 31,445,118 bp (GRCm38)
  • T to A, chromosome 2 at 76,586,210 bp (GRCm38)
  • T to A, chromosome 2 at 76,908,673 bp (GRCm38)
  • T to C, chromosome 2 at 111,088,516 bp (GRCm38)
  • T to C, chromosome 2 at 113,478,917 bp (GRCm38)
  • A to T, chromosome 3 at 89,216,737 bp (GRCm38)
  • T to G, chromosome 3 at 126,942,382 bp (GRCm38)
  • A to G, chromosome 4 at 41,195,661 bp (GRCm38)
  • A to T, chromosome 4 at 108,071,335 bp (GRCm38)
  • A to T, chromosome 4 at 137,455,312 bp (GRCm38)
  • T to A, chromosome 4 at 138,259,109 bp (GRCm38)
  • C to A, chromosome 5 at 41,816,962 bp (GRCm38)
  • G to C, chromosome 5 at 93,636,430 bp (GRCm38)
  • T to A, chromosome 5 at 107,903,855 bp (GRCm38)
  • T to C, chromosome 5 at 108,138,926 bp (GRCm38)
  • T to C, chromosome 5 at 123,954,686 bp (GRCm38)
  • T to C, chromosome 5 at 135,747,780 bp (GRCm38)
  • G to T, chromosome 6 at 34,846,926 bp (GRCm38)
  • T to A, chromosome 6 at 48,677,482 bp (GRCm38)
  • T to G, chromosome 6 at 84,577,017 bp (GRCm38)
  • A to G, chromosome 6 at 90,689,677 bp (GRCm38)
  • A to T, chromosome 7 at 24,003,828 bp (GRCm38)
  • A to C, chromosome 7 at 42,662,921 bp (GRCm38)
  • A to T, chromosome 7 at 80,809,092 bp (GRCm38)
  • A to T, chromosome 7 at 103,767,572 bp (GRCm38)
  • T to C, chromosome 7 at 108,159,868 bp (GRCm38)
  • A to G, chromosome 7 at 141,513,842 bp (GRCm38)
  • G to A, chromosome 8 at 80,615,419 bp (GRCm38)
  • A to T, chromosome 8 at 88,326,398 bp (GRCm38)
  • T to A, chromosome 8 at 109,996,079 bp (GRCm38)
  • A to T, chromosome 9 at 18,409,241 bp (GRCm38)
  • T to C, chromosome 9 at 26,859,633 bp (GRCm38)
  • C to G, chromosome 9 at 108,611,739 bp (GRCm38)
  • G to A, chromosome 10 at 76,763,391 bp (GRCm38)
  • G to A, chromosome 10 at 130,017,476 bp (GRCm38)
  • T to C, chromosome 11 at 5,902,307 bp (GRCm38)
  • T to G, chromosome 12 at 78,562,862 bp (GRCm38)
  • T to A, chromosome 12 at 79,251,272 bp (GRCm38)
  • G to A, chromosome 12 at 116,060,066 bp (GRCm38)
  • A to C, chromosome 13 at 104,352,805 bp (GRCm38)
  • A to T, chromosome 14 at 26,608,603 bp (GRCm38)
  • T to A, chromosome 16 at 3,839,574 bp (GRCm38)
  • C to T, chromosome 16 at 20,595,699 bp (GRCm38)
  • T to C, chromosome 16 at 43,817,005 bp (GRCm38)
  • T to C, chromosome 17 at 14,689,885 bp (GRCm38)
  • C to T, chromosome 17 at 24,721,877 bp (GRCm38)
  • T to A, chromosome 18 at 42,242,981 bp (GRCm38)
  • G to A, chromosome 19 at 3,622,672 bp (GRCm38)
  • A to T, chromosome 19 at 18,786,759 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9536 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069335-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.