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Strain Name:
C57BL/6J-MtgxR9541Btlr/Mmmh
Stock Number:
069340-MU
Citation ID:
RRID:MMRRC_069340-MU
Other Names:
R9541 (G1)
Major Collection:

Strain Information

Hdgfl2
Name: HDGF like 2
Synonyms: HRP-2, Hdgfrp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15193
VEGA: 17
Homologene: 7355
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Trib2
Name: tribbles pseudokinase 2
Synonyms: TRB2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217410
Homologene: 41445
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, 2310047O13Rik, Fam188a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Btbd9
Name: BTB domain containing 9
Synonyms: 1700023F20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224671
VEGA: 17
Homologene: 14995
Med25
Name: mediator complex subunit 25
Synonyms: ESTM2, 2610529E18Rik, 2610034E13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75613
Homologene: 12614
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730455C01Rik, 9130215G10Rik, 5730555F13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226442
Homologene: 8270
Coq5
Name: coenzyme Q5 methyltransferase
Synonyms: 1810014G04Rik, D5Ertd33e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52064
Homologene: 6559
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, C030034P18Rik, TRPP2, PC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Dennd5b
Name: DENN domain containing 5B
Synonyms: 9330160C06Rik, D030011O10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320560
Homologene: 44911
Adamts4
Name: ADAM metallopeptidase with thrombospondin type 1 motif 4
Synonyms: aggrecanase-1, ADAM-TS4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240913
HGNC: HGNC:220
Homologene: 36169
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Kdm5d
Name: lysine demethylase 5D
Synonyms: Smcy, Jarid1d, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Ak9
Name: adenylate kinase 9
Synonyms: LOC215946, Akd2, Gm7127, Akd1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 633979
Homologene: 67934
B4gat1
Name: beta-1,4-glucuronyltransferase 1
Synonyms: BETA3GNT1, iGNT, 1500032M01Rik, B3gnt6, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108902
VEGA: 19
Homologene: 38239
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Sky, Dtk, Etk-2, Tif, Brt, Rse, Sky
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22174
Homologene: 4585
Syne4
Name: spectrin repeat containing, nuclear envelope family member 4
Synonyms: 0610012K07Rik, AI428936, nesprin-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233066
Homologene: 17716
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Rd3
Name: retinal degeneration 3
Synonyms: rd-3, 3322402L07Rik, rd3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74023
Homologene: 11373
Mindy2
Name: MINDY lysine 48 deubiquitinase 2
Synonyms: B230380D07Rik, Fam63b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235461
VEGA: 9
Homologene: 101023
Filip1
Name: filamin A interacting protein 1
Synonyms: 5730485H21Rik, FILIP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Ptpre
Name: protein tyrosine phosphatase receptor type E
Synonyms: PTPe, PTPepsilon, RPTPepsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Fscn2
Name: fascin actin-bundling protein 2
Synonyms: C630046B20Rik, ahl8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 238021
HGNC: HGNC:3960
Homologene: 22722
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Khnyn
Name: KH and NYN domain containing
Synonyms: 9130227C08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219094
VEGA: 14
Homologene: 23611
Or5ak25
Name: olfactory receptor family 5 subfamily AK member 25
Synonyms: GA_x6K02T2Q125-46915844-46914897, MOR203-3, Olfr995
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258426
Homologene: 105170
Gpatch3
Name: G patch domain containing 3
Synonyms: D930035B09Rik, Gpatc3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242691
Homologene: 11122
Rusc1
Name: RUN and SH3 domain containing 1
Synonyms: 2210403N08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72296
Homologene: 75028
Or4f52
Name: olfactory receptor family 4 subfamily F member 52
Synonyms: GA_x6K02T2Q125-72283260-72282322, MOR245-18, Olfr1275
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257980
Homologene: 79419
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Or2h2c
Name: olfactory receptor family 2 subfamily H member 2C
Synonyms: MOR256-29, GA_x6K02T2PSCP-1552066-1551128, Olfr92
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8253
Homologene: 115562
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: CD122, Il-2Rbeta, IL15Rbeta, IL-2/15Rbeta, IL-15 receptor beta chain, IL-15Rbeta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Gmppa
Name: GDP-mannose pyrophosphorylase A
Synonyms: 1810012N01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69080
Homologene: 8346
Slc22a7
Name: solute carrier family 22 (organic anion transporter), member 7
Synonyms: OAT2, NLT
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108114
VEGA: 17
Homologene: 21328
Lmcd1
Name: LIM and cysteine-rich domains 1
Synonyms: dyxin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30937
HGNC: HGNC:6633
Homologene: 22823
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: LOC380650, C030032C09Rik, E530015N03Rik, AIDA-1b, Gm10937
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Npas2
Name: neuronal PAS domain protein 2
Synonyms: MOP4, bHLHe9
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Ciart
Name: circadian associated repressor of transcription
Synonyms: LOC229599, Gm129
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229599
Homologene: 79670
Timm22
Name: translocase of inner mitochondrial membrane 22
Synonyms: 2610511O07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56322
Homologene: 32173
Rasd2
Name: RASD family, member 2
Synonyms: TEM2, TEM-2, Rhes, 4930526B11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75141
Homologene: 8628
Igkv4-81
Name: immunoglobulin kappa variable 4-81
Synonyms: LOC243453
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243453
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 39,338,113 bp (GRCm38)
  • T to A, chromosome 1 at 75,440,450 bp (GRCm38)
  • G to T, chromosome 1 at 136,627,565 bp (GRCm38)
  • C to A, chromosome 1 at 171,257,126 bp (GRCm38)
  • C to A, chromosome 1 at 191,985,333 bp (GRCm38)
  • T to C, chromosome 2 at 12,386,638 bp (GRCm38)
  • T to C, chromosome 2 at 41,344,588 bp (GRCm38)
  • C to T, chromosome 2 at 76,885,013 bp (GRCm38)
  • T to A, chromosome 2 at 85,438,681 bp (GRCm38)
  • T to A, chromosome 2 at 111,230,930 bp (GRCm38)
  • T to C, chromosome 2 at 119,812,108 bp (GRCm38)
  • T to G, chromosome 3 at 89,091,615 bp (GRCm38)
  • C to A, chromosome 3 at 95,881,215 bp (GRCm38)
  • A to T, chromosome 4 at 88,571,773 bp (GRCm38)
  • G to A, chromosome 4 at 133,578,284 bp (GRCm38)
  • A to G, chromosome 5 at 104,460,061 bp (GRCm38)
  • T to C, chromosome 5 at 115,279,842 bp (GRCm38)
  • A to G, chromosome 5 at 115,616,357 bp (GRCm38)
  • A to G, chromosome 6 at 68,990,941 bp (GRCm38)
  • A to T, chromosome 6 at 112,329,863 bp (GRCm38)
  • A to G, chromosome 6 at 148,998,374 bp (GRCm38)
  • G to A, chromosome 7 at 30,316,918 bp (GRCm38)
  • A to G, chromosome 7 at 44,891,843 bp (GRCm38)
  • T to C, chromosome 7 at 46,151,655 bp (GRCm38)
  • A to G, chromosome 7 at 85,407,001 bp (GRCm38)
  • A to G, chromosome 7 at 135,665,011 bp (GRCm38)
  • A to G, chromosome 8 at 41,327,579 bp (GRCm38)
  • T to C, chromosome 8 at 75,218,572 bp (GRCm38)
  • G to A, chromosome 9 at 45,909,470 bp (GRCm38)
  • A to G, chromosome 9 at 58,860,402 bp (GRCm38)
  • A to T, chromosome 9 at 70,297,346 bp (GRCm38)
  • A to T, chromosome 9 at 70,573,775 bp (GRCm38)
  • G to A, chromosome 9 at 70,605,226 bp (GRCm38)
  • T to A, chromosome 9 at 79,819,853 bp (GRCm38)
  • C to T, chromosome 10 at 41,367,177 bp (GRCm38)
  • A to T, chromosome 10 at 90,577,085 bp (GRCm38)
  • A to G, chromosome 11 at 21,997,052 bp (GRCm38)
  • T to A, chromosome 11 at 76,409,815 bp (GRCm38)
  • G to A, chromosome 11 at 120,367,945 bp (GRCm38)
  • T to A, chromosome 12 at 15,816,826 bp (GRCm38)
  • T to C, chromosome 12 at 81,560,950 bp (GRCm38)
  • C to T, chromosome 13 at 44,914,777 bp (GRCm38)
  • T to C, chromosome 14 at 55,886,652 bp (GRCm38)
  • T to A, chromosome 15 at 78,488,193 bp (GRCm38)
  • G to T, chromosome 16 at 29,422,726 bp (GRCm38)
  • A to G, chromosome 17 at 30,220,464 bp (GRCm38)
  • C to T, chromosome 17 at 37,111,932 bp (GRCm38)
  • T to C, chromosome 17 at 46,438,158 bp (GRCm38)
  • T to A, chromosome 17 at 56,098,976 bp (GRCm38)
  • G to A, chromosome 18 at 36,624,644 bp (GRCm38)
  • C to T, chromosome 19 at 5,039,868 bp (GRCm38)
  • T to G, chromosome Y at 910,801 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9541 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069340-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.