Strain Name:
C57BL/6J-MtgxR9578Btlr/Mmmh
Stock Number:
069371-MU
Citation ID:
RRID:MMRRC_069371-MU
Other Names:
R9578 (G1)
Major Collection:

Strain Information

Krt5
Name: keratin 5
Synonyms: Krt2-5, K5, 3300001P10Rik, Tfip8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110308
HGNC: HGNC:6442
Homologene: 55461
Icos
Name: inducible T cell co-stimulator
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54167
HGNC: HGNC:5351
Homologene: 8097
Pomt1
Name: protein-O-mannosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99011
HGNC: HGNC:9202
Homologene: 68548
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 2310047O13Rik, Fam188a, 1810041E18Rik, 5830410F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Rfesd
Name: Rieske (Fe-S) domain containing
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218341
VEGA: 13
Homologene: 18282
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: Zfp403, D330017P12Rik, DIF-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Nol9
Name: nucleolar protein 9
Synonyms: 4632412I24Rik, 6030462G04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74035
Homologene: 32589
Dtna
Name: dystrobrevin alpha
Synonyms: a-DB-1, 2210407P21Rik, alpha-dystrobrevin, A0, 87K protein, adbn, Dtn
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Grm4
Name: glutamate receptor, metabotropic 4
Synonyms: Gprc1d, mGluR4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268934
HGNC: HGNC:4596
Homologene: 20230
Tcea1
Name: transcription elongation factor A (SII) 1
Synonyms: S-II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21399
Homologene: 55984
Gas1
Name: growth arrest specific 1
Synonyms: Gas-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14451
HGNC: HGNC:4165
Homologene: 1548
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Zfp54
Name: zinc finger protein 54
Synonyms: Zfp76, clone 18, Zfp-54, KRAB10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22712
Homologene: 129791
Atp1b3
Name: ATPase, Na+/K+ transporting, beta 3 polypeptide
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11933
HGNC: HGNC:806
Homologene: 37510
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: 2310050N03Rik, mTIA-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21841
Homologene: 20692
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21975
Homologene: 3394
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Dusp4
Name: dual specificity phosphatase 4
Synonyms: MKP2, 2700078F24Rik, E130306H24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319520
HGNC: HGNC:3070
Homologene: 1065
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: LOC382100, D030002L11Rik, Rme8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Kcnk2
Name: potassium channel, subfamily K, member 2
Synonyms: TREK-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16526
HGNC: HGNC:6277
Homologene: 7794
Cfi
Name: complement component factor i
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 5730402K07Rik, 1300003D15Rik, cAMP-GEFII, 6330581N18Rik, Epac2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Or8g35
Name: olfactory receptor family 8 subfamily G member 35
Synonyms: MOR171-34, MOR171-50, GA_x6K02T2PVTD-33167297-33166353, Olfr955
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258242
VEGA: 9
Homologene: 133698
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: C030033M19Rik, RIM1alpha, RIM1, RIM1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Ncdn
Name: neurochondrin
Synonyms: neurochondrin-2, neurochondrin-1, norbin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26562
Homologene: 8064
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: SNM1, 2810043H12Rik, mSNM1, SMN1a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 55947
Homologene: 8920
4933405L10Rik
Name: RIKEN cDNA 4933405L10 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71046
Homologene: 19274
Aldh8a1
Name: aldehyde dehydrogenase 8 family, member A1
Synonyms: RALDH4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237320
Homologene: 23369
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Serpinf2
Name: serine (or cysteine) peptidase inhibitor, clade F, member 2
Synonyms: alpha 2 antiplasmin, Pli
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18816
HGNC: HGNC:9075
Homologene: 719
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54526
Homologene: 10303
Vmn1r230
Name: vomeronasal 1 receptor 230
Synonyms: V1re8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171231
Homologene: 136306
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252905
Homologene: 74318
Pou2f2
Name: POU domain, class 2, transcription factor 2
Synonyms: Oct-2, Otf2, Oct2d, Oct2a, Oct2c, Otf-2, Oct2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18987
HGNC: HGNC:9213
Homologene: 55674
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 620913
Homologene: 83188
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: Miwi2, MIWI2, 9230101H05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330890
Homologene: 45122
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Upk3b
Name: uroplakin 3B
Synonyms: PMS2L14, P35, UpIIIb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100647
Homologene: 18435
Opalin
Name: oligodendrocytic myelin paranodal and inner loop protein
Synonyms: Tmem10, Tmp10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226115
VEGA: 19
Homologene: 13237
Usp18
Name: ubiquitin specific peptidase 18
Synonyms: UBP43, 1110058H21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 24110
Homologene: 8047
B3gnt8
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Synonyms: B3galt7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232984
Homologene: 18886
Dcdc2c
Name: doublecortin domain containing 2C
Synonyms: 1110015M06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68511
Homologene: 131934
Aipl1
Name: aryl hydrocarbon receptor-interacting protein-like 1
Synonyms: A930007I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114230
HGNC: HGNC:359
Homologene: 22806
Pcdha11
Name: protocadherin alpha 11
Synonyms: Cnr7, A830022B16Rik, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 4,890,798 bp (GRCm38)
  • G to A, chromosome 1 at 22,484,742 bp (GRCm38)
  • T to A, chromosome 1 at 60,993,712 bp (GRCm38)
  • G to A, chromosome 1 at 93,335,668 bp (GRCm38)
  • A to G, chromosome 1 at 130,849,613 bp (GRCm38)
  • T to C, chromosome 1 at 181,674,442 bp (GRCm38)
  • CAAA to CAA, chromosome 1 at 189,256,694 bp (GRCm38)
  • C to T, chromosome 2 at 12,356,904 bp (GRCm38)
  • G to A, chromosome 2 at 32,243,531 bp (GRCm38)
  • A to T, chromosome 2 at 72,195,708 bp (GRCm38)
  • A to G, chromosome 2 at 113,839,780 bp (GRCm38)
  • A to G, chromosome 2 at 135,987,524 bp (GRCm38)
  • G to T, chromosome 3 at 129,865,375 bp (GRCm38)
  • C to T, chromosome 4 at 126,752,002 bp (GRCm38)
  • T to C, chromosome 4 at 137,913,822 bp (GRCm38)
  • A to G, chromosome 4 at 152,041,249 bp (GRCm38)
  • A to G, chromosome 5 at 14,766,739 bp (GRCm38)
  • T to A, chromosome 5 at 136,038,882 bp (GRCm38)
  • A to T, chromosome 5 at 136,254,065 bp (GRCm38)
  • T to C, chromosome 6 at 86,430,365 bp (GRCm38)
  • A to G, chromosome 6 at 121,262,767 bp (GRCm38)
  • T to C, chromosome 7 at 11,670,420 bp (GRCm38)
  • C to A, chromosome 7 at 25,097,144 bp (GRCm38)
  • T to C, chromosome 7 at 25,628,664 bp (GRCm38)
  • T to C, chromosome 7 at 85,956,893 bp (GRCm38)
  • G to T, chromosome 8 at 34,807,668 bp (GRCm38)
  • G to A, chromosome 8 at 105,709,873 bp (GRCm38)
  • T to C, chromosome 8 at 122,497,475 bp (GRCm38)
  • A to T, chromosome 9 at 14,727,494 bp (GRCm38)
  • A to T, chromosome 9 at 39,469,905 bp (GRCm38)
  • A to T, chromosome 9 at 96,338,701 bp (GRCm38)
  • A to G, chromosome 9 at 104,238,527 bp (GRCm38)
  • G to A, chromosome 9 at 108,960,282 bp (GRCm38)
  • A to G, chromosome 10 at 21,377,382 bp (GRCm38)
  • A to G, chromosome 10 at 75,754,351 bp (GRCm38)
  • T to A, chromosome 11 at 48,915,581 bp (GRCm38)
  • A to C, chromosome 11 at 60,756,691 bp (GRCm38)
  • C to T, chromosome 11 at 72,037,427 bp (GRCm38)
  • T to A, chromosome 11 at 75,436,789 bp (GRCm38)
  • A to G, chromosome 11 at 84,854,163 bp (GRCm38)
  • G to A, chromosome 11 at 86,702,411 bp (GRCm38)
  • G to T, chromosome 12 at 28,552,235 bp (GRCm38)
  • T to C, chromosome 13 at 60,176,091 bp (GRCm38)
  • C to T, chromosome 13 at 76,008,180 bp (GRCm38)
  • G to T, chromosome 14 at 55,503,836 bp (GRCm38)
  • A to T, chromosome 15 at 89,790,919 bp (GRCm38)
  • T to C, chromosome 15 at 101,711,718 bp (GRCm38)
  • C to A, chromosome 17 at 20,846,901 bp (GRCm38)
  • A to G, chromosome 17 at 21,434,924 bp (GRCm38)
  • A to T, chromosome 17 at 27,450,209 bp (GRCm38)
  • A to G, chromosome 18 at 23,595,555 bp (GRCm38)
  • T to C, chromosome 18 at 37,007,123 bp (GRCm38)
  • A to T, chromosome 19 at 41,072,229 bp (GRCm38)
  • A to G, chromosome 19 at 56,540,302 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9578 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069371-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.