Strain Name:
C57BL/6J-MtgxR9581Btlr/Mmmh
Stock Number:
069374-MU
Citation ID:
RRID:MMRRC_069374-MU
Other Names:
R9581 (G1)
Major Collection:

Strain Information

Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: NO, 2310005C01Rik, nNOS, bNOS, Nos-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81897
Homologene: 68126
Slamf6
Name: SLAM family member 6
Synonyms: KAL1b, SF2000, NTB-A, Ly108, KAL1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30925
Homologene: 49945
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: RPTP-LAR, LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22643
Homologene: 137226
Mib1
Name: MIB E3 ubiquitin protein ligase 1
Synonyms: E430019M12Rik, mindbomb, Mib, mind bomb-1, skeletrophin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225164
Homologene: 10810
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: 2900001A12Rik, ANCO-2, GAC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106585
Homologene: 9059
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Schip1
Name: schwannomin interacting protein 1
Synonyms: SCHIP-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30953
Homologene: 130673
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240725
Homologene: 49408
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: C130023C01Rik, 6330576B01Rik, Fbxo13, Fbx13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50758
Homologene: 79859
Zfp106
Name: zinc finger protein 106
Synonyms: Cd-1, H3a, sirm, Sh3bp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20402
Homologene: 40787
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Dact1
Name: dishevelled-binding antagonist of beta-catenin 1
Synonyms: Frd1, Frodo, THYEX3, Frodo1, Dapper1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 59036
Homologene: 9613
Zfp90
Name: zinc finger protein 90
Synonyms: NK10, Zfp64, 6430515L01Rik, KRAB17, Nk10 expressed protein, Zfp83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22751
Homologene: 86800
Golga1
Name: golgin A1
Synonyms: Golgi97, golgin-97, awag, 0710001G09Rik, 2210418B03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76899
HGNC: HGNC:4424
Homologene: 68223
Adat1
Name: adenosine deaminase, tRNA-specific 1
Synonyms: mADAT1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 30947
HGNC: HGNC:228
Homologene: 8096
Tjp1
Name: tight junction protein 1
Synonyms: ZO-1, ZO1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21872
Homologene: 2445
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKKbeta, IKK2, IKK-2, IKK-beta, IKK[b]
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Tut1
Name: terminal uridylyl transferase 1, U6 snRNA-specific
Synonyms: PAPD2, Tent1, TUTase6, 2700038E08Rik, Rbm21
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70044
VEGA: 19
Homologene: 69361
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: 5830435C13Rik, D2Ertd794e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Foxn3
Name: forkhead box N3
Synonyms: 5430426H20Rik, Ches1l, Ches1, HTLFL1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71375
HGNC: HGNC:1928
Homologene: 135955
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
Synonyms: Ahd-2, ALDH1, E1, Raldh1, Ahd2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11668
HGNC: HGNC:402
Homologene: 110441
Ell2
Name: elongation factor for RNA polymerase II 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 192657
VEGA: 13
Homologene: 8094
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL19, DLP12, LOC380889, Dnahc7l, 4921531P07Rik, Hdhc3, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 545260
Homologene: 44428
Aff3
Name: AF4/FMR2 family, member 3
Synonyms: Laf4, 3222402O04Rik, LAF-4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16764
HGNC: HGNC:6473
Homologene: 1718
Chia1
Name: chitinase, acidic 1
Synonyms: Chia, AMCase, 2200003E03Rik, YNL
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81600
Homologene: 75168
Trim16
Name: tripartite motif-containing 16
Synonyms: EBBP, 9130006M08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94092
Homologene: 4726
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: b2b585Clo, PC6, SPC6, PC5/6A, PC5A, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Mybpc3
Name: myosin binding protein C, cardiac
Synonyms: cardiac C-protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17868
HGNC: HGNC:7551
Homologene: 215
Drc7
Name: dynein regulatory complex subunit 7
Synonyms: Ccdc135, SRG-L, LOC330830
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330830
Homologene: 12996
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140476
Homologene: 15401
Farp1
Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms: Cdep
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Nox3
Name: NADPH oxidase 3
Synonyms: nmf250, het
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224480
HGNC: HGNC:7890
Homologene: 49435
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Cdh2
Name: cadherin 2
Synonyms: N-cadherin, N-CAD, Ncad
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Abcd4
Name: ATP-binding cassette, sub-family D member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Trim7
Name: tripartite motif-containing 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94089
Homologene: 14113
Zfp518a
Name: zinc finger protein 518A
Synonyms: Zfp518, 2810401C22Rik, 6330417C12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Or10h28
Name: olfactory receptor family 10 subfamily H member 28
Synonyms: Olfr63, M4, MOR267-1, GA_x6K02T2NTC5-9778-8828
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258939
Homologene: 130665
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: Raftk, CAKbeta, cellular adhesion kinase beta, proline-rich tyrosine kinase 2, related adhesion focal tyrosine kinase, E430023O05Rik, PYK2, calcium-dependent tyrosine kinase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Herc6
Name: hect domain and RLD 6
Synonyms: 1700121D12Rik, CEB1, Herc5, 4930427L17Rik, 2510038N07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67138
Homologene: 70768
Nmt2
Name: N-myristoyltransferase 2
Synonyms: A930001K02Rik, hNMT-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18108
HGNC: HGNC:7858
Homologene: 101539
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: D11Moh44e, 4932418K24Rik, D11Moh43e, t8130b59
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237930
Homologene: 18229
Tmtc4
Name: transmembrane and tetratricopeptide repeat containing 4
Synonyms: 5730419O14Rik, 4930403J22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70551
Homologene: 32796
Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Synonyms: P-glycoprotein, mdr-3, Mdr1a, Pgy3, MDR3, Pgp, Pgy-3, Evi32, multiple drug resistant 1a, P-gp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
Pdilt
Name: protein disulfide isomerase-like, testis expressed
Synonyms: 1700007B13Rik, PDILT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71830
Homologene: 18382
Or52a20
Name: olfactory receptor family 52 subfamily A member 20
Synonyms: Olfr627, GA_x6K02T2PBJ9-6440320-6440766, MOR22-4, GA_x6K02T2L9TJ-1933-2295, Olfr243
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436002
Homologene: 8420
Lrrc61
Name: leucine rich repeat containing 61
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243371
Homologene: 41538
Cela1
Name: chymotrypsin-like elastase family, member 1
Synonyms: Ela-1, 1810062B19Rik, Ela1, PC-TsF, 1810009A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109901
VEGA: 15
HGNC: HGNC:3308
Homologene: 20454
Pcdhgc4
Name: protocadherin gamma subfamily C, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93707
HGNC: HGNC:8717
Homologene: 110932
Nicn1
Name: nicolin 1
Synonyms: 1500032A17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66257
Homologene: 11936
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 12,805,254 bp (GRCm38)
  • T to A, chromosome 1 at 38,210,185 bp (GRCm38)
  • T to A, chromosome 1 at 58,330,896 bp (GRCm38)
  • A to G, chromosome 1 at 171,934,330 bp (GRCm38)
  • T to C, chromosome 2 at 3,316,175 bp (GRCm38)
  • C to T, chromosome 2 at 26,438,635 bp (GRCm38)
  • G to T, chromosome 2 at 39,019,561 bp (GRCm38)
  • T to C, chromosome 2 at 59,968,956 bp (GRCm38)
  • A to G, chromosome 2 at 91,119,271 bp (GRCm38)
  • C to T, chromosome 2 at 120,535,326 bp (GRCm38)
  • A to G, chromosome 2 at 121,377,447 bp (GRCm38)
  • A to T, chromosome 2 at 182,000,254 bp (GRCm38)
  • TCTGGCC to TC, chromosome 3 at 68,617,727 bp (GRCm38)
  • T to C, chromosome 3 at 106,128,563 bp (GRCm38)
  • T to C, chromosome 4 at 118,235,060 bp (GRCm38)
  • T to G, chromosome 5 at 8,740,428 bp (GRCm38)
  • A to G, chromosome 5 at 117,905,394 bp (GRCm38)
  • G to A, chromosome 6 at 48,568,719 bp (GRCm38)
  • A to T, chromosome 6 at 57,658,116 bp (GRCm38)
  • A to G, chromosome 7 at 65,299,724 bp (GRCm38)
  • GGCGGCGGC to GGCGGCGGCCGCGGCGGC, chromosome 7 at 97,579,918 bp (GRCm38)
  • A to G, chromosome 7 at 103,716,581 bp (GRCm38)
  • A to T, chromosome 7 at 119,500,410 bp (GRCm38)
  • G to T, chromosome 7 at 141,810,062 bp (GRCm38)
  • T to C, chromosome 8 at 22,665,559 bp (GRCm38)
  • C to T, chromosome 8 at 71,359,899 bp (GRCm38)
  • T to C, chromosome 8 at 95,059,154 bp (GRCm38)
  • T to A, chromosome 8 at 106,425,082 bp (GRCm38)
  • C to T, chromosome 8 at 111,979,314 bp (GRCm38)
  • A to G, chromosome 9 at 106,224,311 bp (GRCm38)
  • C to T, chromosome 9 at 108,294,509 bp (GRCm38)
  • A to T, chromosome 10 at 107,711,910 bp (GRCm38)
  • T to C, chromosome 11 at 48,848,060 bp (GRCm38)
  • T to A, chromosome 11 at 62,836,731 bp (GRCm38)
  • A to T, chromosome 11 at 96,158,746 bp (GRCm38)
  • G to A, chromosome 11 at 116,229,834 bp (GRCm38)
  • T to A, chromosome 12 at 64,474,348 bp (GRCm38)
  • A to T, chromosome 12 at 71,318,845 bp (GRCm38)
  • A to G, chromosome 12 at 84,603,988 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • C to T, chromosome 12 at 99,196,776 bp (GRCm38)
  • A to G, chromosome 13 at 75,764,029 bp (GRCm38)
  • G to T, chromosome 13 at 100,214,686 bp (GRCm38)
  • C to T, chromosome 14 at 26,770,028 bp (GRCm38)
  • A to T, chromosome 14 at 66,213,340 bp (GRCm38)
  • A to T, chromosome 14 at 121,243,429 bp (GRCm38)
  • T to C, chromosome 14 at 122,950,586 bp (GRCm38)
  • T to A, chromosome 15 at 95,094,387 bp (GRCm38)
  • C to A, chromosome 15 at 100,181,374 bp (GRCm38)
  • C to T, chromosome 15 at 100,675,380 bp (GRCm38)
  • G to A, chromosome 17 at 3,650,053 bp (GRCm38)
  • C to A, chromosome 17 at 33,269,021 bp (GRCm38)
  • A to T, chromosome 17 at 33,386,756 bp (GRCm38)
  • A to G, chromosome 17 at 63,499,530 bp (GRCm38)
  • A to G, chromosome 17 at 65,983,420 bp (GRCm38)
  • A to G, chromosome 18 at 10,775,701 bp (GRCm38)
  • T to A, chromosome 18 at 16,670,055 bp (GRCm38)
  • A to G, chromosome 18 at 37,817,136 bp (GRCm38)
  • A to G, chromosome 18 at 60,917,088 bp (GRCm38)
  • G to T, chromosome 18 at 67,847,394 bp (GRCm38)
  • T to C, chromosome 19 at 8,964,617 bp (GRCm38)
  • T to C, chromosome 19 at 17,454,832 bp (GRCm38)
  • T to A, chromosome 19 at 20,620,053 bp (GRCm38)
  • T to A, chromosome 19 at 40,911,712 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9581 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069374-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.