Strain Name:
C57BL/6J-MtgxR9582Btlr/Mmmh
Stock Number:
069375-MU
Citation ID:
RRID:MMRRC_069375-MU
Other Names:
R9582 (G1)
Major Collection:

Strain Information

Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, mDomino, p400
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Topors
Name: topoisomerase I binding, arginine/serine-rich
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 106021
Homologene: 4237
Uba3
Name: ubiquitin-like modifier activating enzyme 3
Synonyms: ubiquitin activating enzyme 3, A830034N06Rik, Ube1c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22200
Homologene: 2951
Schip1
Name: schwannomin interacting protein 1
Synonyms: SCHIP-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30953
Homologene: 130673
L2hgdh
Name: L-2-hydroxyglutarate dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217666
VEGA: 12
Homologene: 11767
Nefl
Name: neurofilament, light polypeptide
Synonyms: NF-L, Nfl, NF68, CMT2E
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18039
HGNC: HGNC:7739
Homologene: 4487
Cog7
Name: component of oligomeric golgi complex 7
Synonyms: 5630400E24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233824
Homologene: 33431
Sspn
Name: sarcospan
Synonyms: Krag
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16651
Homologene: 3727
Dact1
Name: dishevelled-binding antagonist of beta-catenin 1
Synonyms: Dapper1, Frd1, THYEX3, Frodo1, Frodo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 59036
Homologene: 9613
Lypla1
Name: lysophospholipase 1
Synonyms: Gm39587, Pla1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18777
HGNC: HGNC:6737
Homologene: 100781
Gp5
Name: glycoprotein 5 platelet
Synonyms: GPV, GP V
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14729
VEGA: 16
HGNC: HGNC:4443
Homologene: 74523
Syt7
Name: synaptotagmin VII
Synonyms: B230112P13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54525
VEGA: 19
Homologene: 20889
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik, sao
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Vwc2
Name: von Willebrand factor C domain containing 2
Synonyms: A930041G11Rik, Brorin, cradin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319922
Homologene: 18542
Itih5
Name: inter-alpha-trypsin inhibitor, heavy chain 5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209378
Homologene: 57115
Srebf1
Name: sterol regulatory element binding transcription factor 1
Synonyms: SREBP-1, ADD-1, SREBP-1c, SREBP-1a, SREBP1, SREBP1c, bHLHd1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20787
Homologene: 3079
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Ddost
Name: dolichyl-di-phosphooligosaccharide-protein glycotransferase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13200
HGNC: HGNC:2728
Homologene: 3821
Stra6
Name: stimulated by retinoic acid gene 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20897
Homologene: 7554
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: DEC1, Sharp2, C130042M06Rik, Stra13, Bhlhb2, eip1 (E47 interaction protein 1), CR8, Stra14, cytokine response gene 8, Clast5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Rpgrip1l
Name: Rpgrip1-like
Synonyms: 1700047E16Rik, Ftm, fantom, Nphp8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244585
Homologene: 18296
Txnip
Name: thioredoxin interacting protein
Synonyms: THIF, VDUP1, mVDUP1, Hyplip1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56338
Homologene: 38186
Pcdhb4
Name: protocadherin beta 4
Synonyms: PcdhbD, Pcdhb5A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Mmp9
Name: matrix metallopeptidase 9
Synonyms: MMP-9, Gel B, gelatinase B, Gelatinase B, Clg4b, B/MMP9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319555
Homologene: 72261
1110002E22Rik
Name: RIKEN cDNA 1110002E22 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102634333
Homologene: 131709
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: ESTM15, 1810073P09Rik, X83337
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75607
Homologene: 19155
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Spag16
Name: sperm associated antigen 16
Synonyms: Pf20, 4930524F24Rik, 4930585K05Rik, Wdr29, 4921511D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66722
Homologene: 11572
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75729
Homologene: 123434
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, Fln2, actin binding protein 280
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Mer, Eyk, Tyro 12, Nyk, nmf12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Mark1
Name: MAP/microtubule affinity regulating kinase 1
Synonyms: Emk3, B930025N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226778
HGNC: HGNC:6896
Homologene: 49552
Dyrk1b
Name: dual-specificity tyrosine phosphorylation regulated kinase 1b
Synonyms: Mirk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13549
HGNC: HGNC:3092
Homologene: 31253
Slc2a4
Name: solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms: Glut-4, Glut4, twgy
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20528
Homologene: 74381
Pde8b
Name: phosphodiesterase 8B
Synonyms: C030047E14Rik, B230331L10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Stoml2
Name: stomatin (Epb7.2)-like 2
Synonyms: 0610038F01Rik, SLP-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66592
Homologene: 8389
Gbp10
Name: guanylate-binding protein 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 626578
Homologene: 128731
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Ol5, ferroportin1, IREG1, FPN1, metal transporting protein 1, MTP1, Dusg, Slc11a3, Pcm
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53945
Homologene: 40959
H2-Bl
Name: histocompatibility 2, blastocyst
Synonyms: blastocyst MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14963
Homologene: 128352
P4ha2
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
Synonyms: P4hl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18452
HGNC: HGNC:8547
Homologene: 55806
Pknox2
Name: Pbx/knotted 1 homeobox 2
Synonyms: Prep2, D230005H23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208076
Homologene: 32527
Vmn1r6
Name: vomeronasal 1 receptor 6
Synonyms: V1rc20
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171193
Homologene: 128340
Ces1a
Name: carboxylesterase 1A
Synonyms: Gm4976
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244595
HGNC: HGNC:1863
Homologene: 134142
Csrnp2
Name: cysteine-serine-rich nuclear protein 2
Synonyms: CSRNP-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207785
VEGA: 15
Homologene: 32743
Ly6g6e
Name: lymphocyte antigen 6 family member G6E
Synonyms: G6e, 2310011I02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70274
Homologene: 41553
Rad18
Name: RAD18 E3 ubiquitin protein ligase
Synonyms: 2810024C04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58186
Homologene: 48572
Leng9
Name: leukocyte receptor cluster (LRC) member 9
Synonyms: 9530024C23Rik, F630035L11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243813
Homologene: 18466
Pced1b
Name: PC-esterase domain containing 1B
Synonyms: Fam113b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239647
VEGA: 15
Homologene: 16301
Arpin
Name: actin-related protein 2/3 complex inhibitor
Synonyms: 2610034B18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70420
Homologene: 128480
Nicn1
Name: nicolin 1
Synonyms: 1500032A17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66257
Homologene: 11936
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 4,841,025 bp (GRCm38)
  • A to G, chromosome 1 at 45,911,339 bp (GRCm38)
  • A to G, chromosome 1 at 69,858,558 bp (GRCm38)
  • A to G, chromosome 1 at 184,919,661 bp (GRCm38)
  • A to G, chromosome 2 at 10,190,202 bp (GRCm38)
  • G to A, chromosome 2 at 128,782,607 bp (GRCm38)
  • A to C, chromosome 2 at 164,949,315 bp (GRCm38)
  • TCTGGCC to TC, chromosome 3 at 68,617,727 bp (GRCm38)
  • T to A, chromosome 3 at 96,558,343 bp (GRCm38)
  • T to A, chromosome 3 at 138,067,005 bp (GRCm38)
  • A to T, chromosome 4 at 40,260,460 bp (GRCm38)
  • A to T, chromosome 4 at 43,030,238 bp (GRCm38)
  • A to T, chromosome 4 at 138,308,272 bp (GRCm38)
  • A to G, chromosome 5 at 105,224,390 bp (GRCm38)
  • A to C, chromosome 5 at 110,676,449 bp (GRCm38)
  • A to T, chromosome 5 at 142,771,373 bp (GRCm38)
  • C to A, chromosome 6 at 29,460,737 bp (GRCm38)
  • A to G, chromosome 6 at 57,002,940 bp (GRCm38)
  • G to T, chromosome 6 at 83,404,244 bp (GRCm38)
  • A to T, chromosome 6 at 97,191,530 bp (GRCm38)
  • A to G, chromosome 6 at 108,661,506 bp (GRCm38)
  • A to G, chromosome 6 at 112,681,337 bp (GRCm38)
  • C to T, chromosome 6 at 145,953,608 bp (GRCm38)
  • A to G, chromosome 7 at 4,149,264 bp (GRCm38)
  • C to T, chromosome 7 at 28,182,603 bp (GRCm38)
  • T to C, chromosome 7 at 79,935,290 bp (GRCm38)
  • T to C, chromosome 7 at 121,936,977 bp (GRCm38)
  • A to G, chromosome 8 at 72,695,289 bp (GRCm38)
  • C to T, chromosome 8 at 91,270,258 bp (GRCm38)
  • C to T, chromosome 8 at 93,039,528 bp (GRCm38)
  • T to A, chromosome 9 at 36,892,956 bp (GRCm38)
  • T to A, chromosome 9 at 58,147,487 bp (GRCm38)
  • C to T, chromosome 9 at 108,294,509 bp (GRCm38)
  • T to A, chromosome 11 at 11,116,129 bp (GRCm38)
  • T to A, chromosome 11 at 54,131,239 bp (GRCm38)
  • C to A, chromosome 11 at 60,207,042 bp (GRCm38)
  • C to T, chromosome 11 at 69,946,624 bp (GRCm38)
  • A to T, chromosome 12 at 21,336,664 bp (GRCm38)
  • A to G, chromosome 12 at 69,692,398 bp (GRCm38)
  • A to T, chromosome 12 at 71,318,845 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • A to G, chromosome 13 at 37,930,758 bp (GRCm38)
  • A to G, chromosome 13 at 49,057,499 bp (GRCm38)
  • A to G, chromosome 13 at 95,032,861 bp (GRCm38)
  • A to G, chromosome 14 at 68,087,400 bp (GRCm38)
  • A to G, chromosome 15 at 79,617,777 bp (GRCm38)
  • A to G, chromosome 15 at 97,384,569 bp (GRCm38)
  • C to T, chromosome 15 at 100,488,186 bp (GRCm38)
  • A to G, chromosome 16 at 30,308,239 bp (GRCm38)
  • T to C, chromosome 17 at 35,077,183 bp (GRCm38)
  • T to A, chromosome 17 at 36,081,483 bp (GRCm38)
  • T to A, chromosome 18 at 37,308,364 bp (GRCm38)
  • T to C, chromosome 19 at 10,439,416 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9582 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069375-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.