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Strain Name:
C57BL/6J-MtgxR9590Btlr/Mmmh
Stock Number:
069383-MU
Citation ID:
RRID:MMRRC_069383-MU
Other Names:
R9590 (G1)
Major Collection:

Strain Information

Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: Tak1-binding protein 1, 2310012M03Rik, Map3k7ip1, b2b449Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Eif1
Name: eukaryotic translation initiation factor 1
Synonyms: Sui1-rs1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20918
HGNC: HGNC:3249
Homologene: 135931
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Cnr1
Name: cannabinoid receptor 1
Synonyms: CB1, CB1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12801
HGNC: HGNC:2159
Homologene: 7273
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: Nix, D14Ertd719e, Nip3L
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, alpha1A, Ccha1a, SCA6, nmf352, smrl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Cfi
Name: complement component factor i
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 674895
Homologene: 130947
Mmp9
Name: matrix metallopeptidase 9
Synonyms: gelatinase B, Gel B, MMP-9, B/MMP9, Clg4b, Gelatinase B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100066
HGNC: HGNC:2634
Homologene: 133819
Faap100
Name: Fanconi anemia core complex associated protein 100
Synonyms: 2310003H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71885
Homologene: 69394
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: Smr, 4930442N21Rik, 9330180L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54650
Homologene: 9472
Man1a
Name: mannosidase 1, alpha
Synonyms: PCR1, mannosyl-oligosaccharide alpha-1,2-mannosidase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17155
HGNC: HGNC:6821
Homologene: 4316
Galnt13
Name: polypeptide N-acetylgalactosaminyltransferase 13
Synonyms: pp-GalNAc-T13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271786
Homologene: 62167
C9orf72
Name: C9orf72, member of C9orf72-SMCR8 complex
Synonyms: 3110043O21Rik, Dennd9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73205
Homologene: 10137
Dnase2b
Name: deoxyribonuclease II beta
Synonyms: DnaseIIb, Dlad
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56629
Homologene: 1052
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Tob2
Name: transducer of ERBB2, 2
Synonyms: 2900090N22Rik, 4930545K18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 57259
VEGA: 15
Homologene: 9447
Mlip
Name: muscular LMNA-interacting protein
Synonyms: 2310046A06Rik, cardiac ISL1-interacting protein, CIP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69642
Homologene: 90445
Ace
Name: angiotensin I converting enzyme
Synonyms: CD143
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Fkbp10
Name: FK506 binding protein 10
Synonyms: FKBP65, Fkbp1-rs, Fkbp-rs1, Fkbp6, 65kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14230
Homologene: 7718
Proser2
Name: proline and serine rich 2
Synonyms: 5430407P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227545
Homologene: 51648
Or5b12b
Name: olfactory receptor family 5 subfamily B member 12B
Synonyms: GA_x6K02T2RE5P-3213352-3214296, MOR202-7, Olfr1445
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258694
Homologene: 133606
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73779
Homologene: 136277
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54667
Homologene: 23226
Padi1
Name: peptidyl arginine deiminase, type I
Synonyms: Pdi1, Pad type 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18599
Homologene: 7881
Ppil6
Name: peptidylprolyl isomerase (cyclophilin)-like 6
Synonyms: 2900084F20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73075
VEGA: 10
Homologene: 52155
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Calml4
Name: calmodulin-like 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75600
VEGA: 9
Homologene: 77215
Or51a7
Name: olfactory receptor family 51 subfamily A member 7
Synonyms: GA_x6K02T2PBJ9-5676385-5677371, MOR8-5, Olfr576
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258248
Homologene: 45856
Pcbp4
Name: poly(rC) binding protein 4
Synonyms: AlphaCP-4, 1200003L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59092
HGNC: HGNC:8652
Homologene: 56926
Gm32742
Name: predicted gene, 32742
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102635385
Homologene: 132734
Or8g29-ps1
Name: olfactory receptor family 8 subfamily G member 29, pseudogene 1
Synonyms: GA_x6K02T2PVTD-32987171-32986232, MOR171-43, Olfr947-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257924
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 2 at 6,100,983 bp (GRCm38)
  • G to T, chromosome 2 at 54,857,961 bp (GRCm38)
  • A to G, chromosome 2 at 66,483,984 bp (GRCm38)
  • T to A, chromosome 2 at 164,948,914 bp (GRCm38)
  • A to T, chromosome 3 at 89,958,386 bp (GRCm38)
  • A to T, chromosome 3 at 129,848,812 bp (GRCm38)
  • A to T, chromosome 3 at 146,584,568 bp (GRCm38)
  • G to T, chromosome 4 at 33,944,849 bp (GRCm38)
  • C to T, chromosome 4 at 35,218,557 bp (GRCm38)
  • T to A, chromosome 4 at 96,307,377 bp (GRCm38)
  • G to A, chromosome 4 at 101,890,421 bp (GRCm38)
  • T to C, chromosome 4 at 140,817,241 bp (GRCm38)
  • C to A, chromosome 5 at 87,843,135 bp (GRCm38)
  • T to A, chromosome 7 at 43,530,213 bp (GRCm38)
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,911 bp (GRCm38)
  • A to G, chromosome 7 at 101,511,550 bp (GRCm38)
  • T to C, chromosome 7 at 102,965,346 bp (GRCm38)
  • C to T, chromosome 8 at 84,601,981 bp (GRCm38)
  • A to T, chromosome 9 at 39,289,780 bp (GRCm38)
  • A to G, chromosome 9 at 51,139,161 bp (GRCm38)
  • A to G, chromosome 9 at 62,875,528 bp (GRCm38)
  • A to G, chromosome 9 at 77,138,552 bp (GRCm38)
  • T to C, chromosome 9 at 106,463,201 bp (GRCm38)
  • T to C, chromosome 10 at 41,490,482 bp (GRCm38)
  • A to G, chromosome 10 at 53,907,964 bp (GRCm38)
  • C to T, chromosome 11 at 100,320,041 bp (GRCm38)
  • A to T, chromosome 11 at 100,415,959 bp (GRCm38)
  • A to G, chromosome 11 at 105,985,680 bp (GRCm38)
  • G to A, chromosome 11 at 120,378,719 bp (GRCm38)
  • A to G, chromosome 13 at 63,061,109 bp (GRCm38)
  • C to A, chromosome 14 at 14,853,888 bp (GRCm38)
  • T to C, chromosome 14 at 30,790,770 bp (GRCm38)
  • T to G, chromosome 14 at 50,892,585 bp (GRCm38)
  • G to A, chromosome 14 at 67,008,765 bp (GRCm38)
  • A to T, chromosome 15 at 80,155,896 bp (GRCm38)
  • A to C, chromosome 15 at 81,850,867 bp (GRCm38)
  • T to C, chromosome 18 at 44,459,910 bp (GRCm38)
  • T to C, chromosome 19 at 12,884,616 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9590 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069383-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.