Strain Name:
C57BL/6J-MtgxR9591Btlr/Mmmh
Stock Number:
069384-MU
Citation ID:
RRID:MMRRC_069384-MU
Other Names:
R9591 (G1)
Major Collection:

Strain Information

Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: D17Rp17e, Mekk4, T-associated sex reversal, D17Rp17, MTK1, MAPKKK4, RP17, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Btbd9
Name: BTB domain containing 9
Synonyms: 1700023F20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224671
VEGA: 17
Homologene: 14995
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Tbck
Name: TBC1 domain containing kinase
Synonyms: 1700120J03Rik, C030007I09Rik, A630047E20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271981
Homologene: 13221
Lpcat1
Name: lysophosphatidylcholine acyltransferase 1
Synonyms: LPCAT, Aytl2, 2900035H07Rik, rd11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210992
Homologene: 9871
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: D14Ertd719e, Nip3L, Nix
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Sec1
Name: secretory blood group 1
Synonyms: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III, Fut3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56546
Homologene: 431
Zfp148
Name: zinc finger protein 148
Synonyms: BERF-1, 2210405J08Rik, beta enolase repressor factor 1, BFCOL1, ZBP-89
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, C230081A13Rik, NKF3 kinase family member
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC382129, 9430076A06Rik, LOC234973
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Gm20114, Shn-2, MIBP1, Schnurri-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Ccdc116
Name: coiled-coil domain containing 116
Synonyms: 4930432J16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76872
Homologene: 51873
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Dhrs11
Name: dehydrogenase/reductase 11
Synonyms: dehydrogenase/reductase (SDR family) member 11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192970
Homologene: 41560
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434341
Homologene: 88935
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC5, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
C4b
Name: complement C4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12268
Homologene: 36030
Rnpepl1
Name: arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms: 1110014H17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108657
Homologene: 36367
Cd19
Name: CD19 antigen
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12478
HGNC: HGNC:1633
Homologene: 1341
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319713
VEGA: 18
Homologene: 69175
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
C9orf72
Name: C9orf72, member of C9orf72-SMCR8 complex
Synonyms: 3110043O21Rik, Dennd9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73205
Homologene: 10137
Crygn
Name: crystallin, gamma N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 214301
Homologene: 16986
Adam24
Name: ADAM metallopeptidase domain 24
Synonyms: Dtgn5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Neu1
Name: neuraminidase 1
Synonyms: sialidase 1, lysosomal sialidase, Bat7, Aglp, Apl, Neu-1, G9, Map-2, Bat-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18010
HGNC: HGNC:7758
Homologene: 375
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rlf, Rab2l, KE1.5, Rgt2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Nfam1
Name: Nfat activating molecule with ITAM motif 1
Synonyms: Nfam1, 4921501M20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74039
Homologene: 12528
Arhgap25
Name: Rho GTPase activating protein 25
Synonyms: A130039I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232201
Homologene: 45507
Opn1sw
Name: opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
Synonyms: UV cone pigment, SWS opsin, Blue Opsin, Short Wavelength Sensitive opsin, Blue/UV Opsin, Bcp, S Opsin, Blue Cone Opsin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12057
HGNC: HGNC:1012
Homologene: 1291
Sprr2a3
Name: small proline-rich protein 2A3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100042514
Ankrd13d
Name: ankyrin repeat domain 13 family, member D
Synonyms: 0710001P18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68423
Homologene: 27612
Or51b6
Name: olfactory receptor family 51 subfamily B member 6
Synonyms: 5'[b]3, MOR1-2, GA_x6K02T2PBJ9-6634906-6633983, Olfr65
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18365
Homologene: 66459
2510039O18Rik
Name: RIKEN cDNA 2510039O18 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77034
Homologene: 12668
Tmprss11a
Name: transmembrane protease, serine 11a
Synonyms: LOC194597
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 194597
Homologene: 62723
Cldn19
Name: claudin 19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242653
HGNC: HGNC:2040
Homologene: 17528
Iapp
Name: islet amyloid polypeptide
Synonyms: amylin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15874
HGNC: HGNC:5329
Homologene: 36024
Gm3667
Name: predicted gene 3667
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042100
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 82,288,248 bp (GRCm38)
  • T to C, chromosome 1 at 92,919,587 bp (GRCm38)
  • T to A, chromosome 3 at 92,288,654 bp (GRCm38)
  • T to A, chromosome 3 at 132,694,434 bp (GRCm38)
  • C to T, chromosome 4 at 35,218,557 bp (GRCm38)
  • A to G, chromosome 4 at 119,257,160 bp (GRCm38)
  • T to A, chromosome 4 at 147,945,031 bp (GRCm38)
  • G to T, chromosome 5 at 24,756,075 bp (GRCm38)
  • C to T, chromosome 5 at 86,420,038 bp (GRCm38)
  • T to A, chromosome 6 at 29,378,927 bp (GRCm38)
  • T to C, chromosome 6 at 87,463,120 bp (GRCm38)
  • T to A, chromosome 6 at 142,303,337 bp (GRCm38)
  • G to A, chromosome 7 at 45,678,678 bp (GRCm38)
  • A to T, chromosome 7 at 103,907,263 bp (GRCm38)
  • A to G, chromosome 7 at 126,412,124 bp (GRCm38)
  • A to G, chromosome 7 at 141,858,779 bp (GRCm38)
  • C to A, chromosome 8 at 40,679,659 bp (GRCm38)
  • T to G, chromosome 8 at 94,522,681 bp (GRCm38)
  • A to T, chromosome 8 at 125,492,373 bp (GRCm38)
  • T to C, chromosome 9 at 16,377,040 bp (GRCm38)
  • C to A, chromosome 9 at 56,259,550 bp (GRCm38)
  • A to G, chromosome 10 at 14,143,896 bp (GRCm38)
  • T to G, chromosome 11 at 84,828,758 bp (GRCm38)
  • T to G, chromosome 13 at 73,511,352 bp (GRCm38)
  • T to C, chromosome 14 at 6,873,057 bp (GRCm38)
  • G to A, chromosome 14 at 67,008,765 bp (GRCm38)
  • T to C, chromosome 15 at 83,016,380 bp (GRCm38)
  • T to C, chromosome 16 at 17,142,734 bp (GRCm38)
  • T to A, chromosome 16 at 33,495,367 bp (GRCm38)
  • C to A, chromosome 17 at 12,235,908 bp (GRCm38)
  • A to T, chromosome 17 at 19,811,659 bp (GRCm38)
  • T to C, chromosome 17 at 30,517,248 bp (GRCm38)
  • C to T, chromosome 17 at 33,932,477 bp (GRCm38)
  • A to T, chromosome 17 at 34,738,955 bp (GRCm38)
  • T to C, chromosome 17 at 34,931,498 bp (GRCm38)
  • G to A, chromosome 17 at 71,394,833 bp (GRCm38)
  • T to C, chromosome 18 at 61,821,913 bp (GRCm38)
  • A to G, chromosome 19 at 4,270,222 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9591 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069384-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.