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Strain Name:
C57BL/6J-MtgxR9594Btlr/Mmmh
Stock Number:
069387-MU
Citation ID:
RRID:MMRRC_069387-MU
Other Names:
R9594 (G1)
Major Collection:

Strain Information

Sufu
Name: SUFU negative regulator of hedgehog signaling
Synonyms: Su(Fu), 2810026F04Rik, b2b273Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24069
Homologene: 9262
Apobec3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms: Rfv-3, CEM15, Rfv3, Gm20117
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 80287
Homologene: 105420
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Hcn2
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Synonyms: HAC1, trls
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15166
HGNC: HGNC:4846
Homologene: 31022
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319939
Homologene: 49713
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Atf6
Name: activating transcription factor 6
Synonyms: ESTM49, 9130025P16Rik, Atf6alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226641
HGNC: HGNC:791
Homologene: 32015
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Synonyms: SHP-1, Ptp1C, hcp, Hcph
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15170
HGNC: HGNC:9658
Homologene: 56589
Ehmt2
Name: euchromatic histone lysine N-methyltransferase 2
Synonyms: NG36, G9a, D17Ertd710e, Bat8, KMT1C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110147
Homologene: 48460
Btg1
Name: BTG anti-proliferation factor 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12226
VEGA: 10
HGNC: HGNC:1130
Homologene: 37521
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Olfm3
Name: olfactomedin 3
Synonyms: optimedin, B230206G02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229759
Homologene: 17103
Dync1li2
Name: dynein, cytoplasmic 1 light intermediate chain 2
Synonyms: LIC2, Dncli2, Dnclic2, Dlic2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234663
HGNC: HGNC:2966
Homologene: 4474
Brd3
Name: bromodomain containing 3
Synonyms: RINGL3, ORFX, 2410084F24Rik, Fsrg2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67382
HGNC: HGNC:1104
Homologene: 81801
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329002
Homologene: 7198
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 252972
Homologene: 9905
Foxn3
Name: forkhead box N3
Synonyms: HTLFL1, 5430426H20Rik, Ches1l, Ches1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71375
HGNC: HGNC:1928
Homologene: 135955
Grm2
Name: glutamate receptor, metabotropic 2
Synonyms: mGluR2, 4930441L02Rik, Gprc1b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108068
HGNC: HGNC:4594
Homologene: 20229
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Akap3
Name: A kinase anchor protein 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11642
HGNC: HGNC:373
Homologene: 4688
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Stk31
Name: serine threonine kinase 31
Synonyms: C330007K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77485
Homologene: 12677
Trim45
Name: tripartite motif-containing 45
Synonyms: 4921530N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229644
Homologene: 11865
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: IMP150, SPACR, A930015H12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Stac3
Name: SH3 and cysteine rich domain 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237611
Homologene: 17039
Lipe
Name: lipase, hormone sensitive
Synonyms: HSL, 4933403G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Ghrhr
Name: growth hormone releasing hormone receptor
Synonyms: Ghrfr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14602
HGNC: HGNC:4266
Homologene: 640
Cdhr18
Name: cadherin related family member 18
Synonyms: LOC238939, Gm281
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238939
Homologene: 141164
Cd209e
Name: CD209e antigen
Synonyms: SIGNR4, mSIGNR4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170780
HGNC: HGNC:1641
Homologene: 128353
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15042
Homologene: 69019
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 434484
Homologene: 128391
Spmip6
Name: sperm microtubule inner protein 6
Synonyms: Smrp1, Cbe1, 1110017D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73721
Homologene: 13074
Or5l13
Name: olfactory receptor family 5 subfamily L member 13
Synonyms: GA_x6K02T2Q125-49433499-49432537, MOR174-3, Olfr1156
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258814
HGNC: HGNC:8351
Homologene: 72031
Slc13a1
Name: solute carrier family 13 (sodium/sulfate symporters), member 1
Synonyms: NaSi-1, Nas1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55961
Homologene: 31893
Or6c8b
Name: olfactory receptor family 6 subfamily C member 8B
Synonyms: GA_x6K02T2PULF-10732607-10731678, MOR115-4, Olfr765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 544748
Homologene: 105186
Gpcpd1
Name: glycerophosphocholine phosphodiesterase 1
Synonyms: 2310032D16Rik, 2310004G06Rik, Prei4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74182
Homologene: 10478
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113847
Homologene: 130651
Rabac1
Name: Rab acceptor 1 (prenylated)
Synonyms: PRA1, Gbpap1, 2310040I06Rik, prenylin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14470
HGNC: HGNC:9794
Homologene: 38182
Fstl4
Name: follistatin-like 4
Synonyms: B230374F23Rik, SPIG1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
Rnf150
Name: ring finger protein 150
Synonyms: Greul5, A630007N06Rik, C030044C12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330812
Homologene: 33783
Or5g27
Name: olfactory receptor family 5 subfamily G member 27
Synonyms: GA_x6K02T2Q125-47058060-47059004, MOR175-4, Olfr996
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258429
Homologene: 85934
Cimip2b
Name: ciliary microtubule inner protein 2B
Synonyms: 4833436C18Rik, Fam166b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329831
Homologene: 52229
Scarf2
Name: scavenger receptor class F, member 2
Synonyms: Srec2, SREC-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224024
VEGA: 16
Homologene: 17817
Or5p59
Name: olfactory receptor family 5 subfamily P member 59
Synonyms: GA_x6K02T2PBJ9-10432095-10433042, MOR204-12, Olfr483
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258730
Homologene: 133602
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nl1, NEPLP gamma, NEPLP beta, NEPLP alpha, SEP, Mell1, Nep2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27390
Homologene: 22778
Pcbd2
Name: pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
Synonyms: Dcoh2, Dcohm, 2700061N24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72562
Homologene: 49987
Mrfap1
Name: Morf4 family associated protein 1
Synonyms: PAM14, 9130413I22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67568
Homologene: 128357
Or10ak13
Name: olfactory receptor family 10 subfamily AK member 13
Synonyms: GA_x6K02SYWGW3-414-3, GA_x6K02T2QD9B-18767132-18768073, MOR259-10, Olfr219-ps1, Olfr1337
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258306
Homologene: 121524
Aida
Name: axin interactor, dorsalization associated
Synonyms: 2610208M17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108909
Homologene: 11268
Btg4
Name: BTG anti-proliferation factor 4
Synonyms: PC3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56057
VEGA: 9
Homologene: 9734
Or2i1
Name: olfactory receptor family 2 subfamily I member 1
Synonyms: MOR256-32P, GA_x6K02T2PSCP-1637650-1636712, Olfr94
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258219
HGNC: HGNC:8258
Homologene: 79123
Nherf2
Name: NHERF family PDZ scaffold protein 2
Synonyms: Nherf2, Octs2, Tka-1, Sip-1, E3karp, 1200011K07Rik, Sip1, 2010007A20Rik, 0610011L07Rik, Sryip1, Slc9a3r2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 65962
VEGA: 17
Homologene: 56962
G6pc1
Name: glucose-6-phosphatase catalytic subunit 1
Synonyms: G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha, G6pc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14377
HGNC: HGNC:4056
Homologene: 20079
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76877
HGNC: HGNC:9775
Homologene: 3610
Gpr143
Name: G protein-coupled receptor 143
Synonyms: Oa1
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 18241
Homologene: 230
Bcl6b
Name: B cell CLL/lymphoma 6, member B
Synonyms: Bazf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12029
HGNC: HGNC:1002
Homologene: 7243
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to C, chromosome 1 at 30,829,922 bp (GRCm38)
  • A to G, chromosome 1 at 85,632,514 bp (GRCm38)
  • A to G, chromosome 1 at 170,840,833 bp (GRCm38)
  • T to C, chromosome 1 at 183,314,077 bp (GRCm38)
  • G to T, chromosome 2 at 27,450,361 bp (GRCm38)
  • C to T, chromosome 2 at 30,346,660 bp (GRCm38)
  • C to T, chromosome 2 at 85,579,538 bp (GRCm38)
  • T to C, chromosome 2 at 87,950,200 bp (GRCm38)
  • A to G, chromosome 2 at 101,644,356 bp (GRCm38)
  • A to T, chromosome 2 at 132,546,928 bp (GRCm38)
  • A to T, chromosome 2 at 177,193,980 bp (GRCm38)
  • A to T, chromosome 3 at 60,613,438 bp (GRCm38)
  • A to G, chromosome 3 at 98,134,573 bp (GRCm38)
  • A to G, chromosome 3 at 100,922,949 bp (GRCm38)
  • A to G, chromosome 3 at 115,090,136 bp (GRCm38)
  • T to C, chromosome 4 at 41,505,091 bp (GRCm38)
  • T to G, chromosome 4 at 43,427,329 bp (GRCm38)
  • T to C, chromosome 4 at 118,781,755 bp (GRCm38)
  • T to C, chromosome 4 at 154,894,135 bp (GRCm38)
  • C to A, chromosome 5 at 36,796,463 bp (GRCm38)
  • T to C, chromosome 5 at 120,547,956 bp (GRCm38)
  • T to C, chromosome 5 at 124,830,043 bp (GRCm38)
  • T to A, chromosome 6 at 23,025,027 bp (GRCm38)
  • A to G, chromosome 6 at 24,089,101 bp (GRCm38)
  • A to G, chromosome 6 at 41,670,839 bp (GRCm38)
  • C to T, chromosome 6 at 49,447,287 bp (GRCm38)
  • A to G, chromosome 6 at 55,385,485 bp (GRCm38)
  • G to A, chromosome 6 at 89,869,895 bp (GRCm38)
  • C to A, chromosome 6 at 124,727,765 bp (GRCm38)
  • T to C, chromosome 6 at 126,865,414 bp (GRCm38)
  • A to G, chromosome 7 at 24,972,154 bp (GRCm38)
  • T to C, chromosome 7 at 25,398,703 bp (GRCm38)
  • T to G, chromosome 7 at 108,103,456 bp (GRCm38)
  • T to C, chromosome 8 at 3,851,183 bp (GRCm38)
  • T to A, chromosome 8 at 82,990,515 bp (GRCm38)
  • C to A, chromosome 8 at 104,428,120 bp (GRCm38)
  • A to G, chromosome 9 at 51,119,260 bp (GRCm38)
  • A to G, chromosome 9 at 80,381,641 bp (GRCm38)
  • G to A, chromosome 9 at 106,647,209 bp (GRCm38)
  • T to A, chromosome 10 at 75,052,041 bp (GRCm38)
  • C to T, chromosome 10 at 79,724,725 bp (GRCm38)
  • T to A, chromosome 10 at 96,617,401 bp (GRCm38)
  • T to A, chromosome 10 at 127,502,785 bp (GRCm38)
  • T to A, chromosome 10 at 129,046,485 bp (GRCm38)
  • G to A, chromosome 11 at 8,451,142 bp (GRCm38)
  • C to T, chromosome 11 at 52,773,867 bp (GRCm38)
  • A to G, chromosome 11 at 70,228,032 bp (GRCm38)
  • T to C, chromosome 11 at 75,165,931 bp (GRCm38)
  • T to C, chromosome 11 at 97,334,901 bp (GRCm38)
  • T to C, chromosome 11 at 101,367,834 bp (GRCm38)
  • C to A, chromosome 12 at 99,393,035 bp (GRCm38)
  • A to G, chromosome 13 at 55,733,036 bp (GRCm38)
  • A to T, chromosome 14 at 13,814,959 bp (GRCm38)
  • A to G, chromosome 14 at 101,918,700 bp (GRCm38)
  • T to A, chromosome 15 at 66,735,260 bp (GRCm38)
  • T to A, chromosome 15 at 79,906,452 bp (GRCm38)
  • G to T, chromosome 16 at 17,802,609 bp (GRCm38)
  • G to T, chromosome 17 at 24,649,948 bp (GRCm38)
  • C to A, chromosome 17 at 34,899,764 bp (GRCm38)
  • A to T, chromosome 17 at 36,015,563 bp (GRCm38)
  • C to G, chromosome 17 at 37,197,417 bp (GRCm38)
  • G to T, chromosome 18 at 82,646,113 bp (GRCm38)
  • T to C, chromosome 19 at 37,287,115 bp (GRCm38)
  • T to C, chromosome 19 at 46,397,235 bp (GRCm38)
  • GTTTTTT to GTTTTTTT, chromosome X at 152,795,631 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9594 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069387-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.