Strain Name:
C57BL/6J-MtgxR9597Btlr/Mmmh
Stock Number:
069390-MU
Citation ID:
RRID:MMRRC_069390-MU
Other Names:
R9597 (G1)
Major Collection:

Strain Information

Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
Synonyms: DDF1, PARP-7, PARP7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99929
Homologene: 9167
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Cep68
Name: centrosomal protein 68
Synonyms: 6030463E10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216543
Homologene: 65235
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Rgs2
Name: regulator of G-protein signaling 2
Synonyms: GOS8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19735
HGNC: HGNC:9998
Homologene: 2192
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: SK2, fri, bc, small conductance calcium-activated potassium channel 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Mfsd14b
Name: major facilitator superfamily domain containing 14B
Synonyms: 5730414C17Rik, Hiatl1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66631
Homologene: 64464
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Inpp5f
Name: inositol polyphosphate-5-phosphatase F
Synonyms: SAC2, 5830435P03Rik, cI-27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101490
Homologene: 8962
Fem1c
Name: fem 1 homolog c
Synonyms: 2610312A07Rik, 3632443A22Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240263
Homologene: 10606
Firrm
Name: FIGNL1 interacting regulator of recombination and mitosis
Synonyms: FLIP, BC055324
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381306
Homologene: 10058
Clec4a2
Name: C-type lectin domain family 4, member a2
Synonyms: Dcir1, Clecsf6, DCIR, dendritic cell immunoreceptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26888
Homologene: 49291
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: D030022P06Rik, F630004O05Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Tcaim
Name: T cell activation inhibitor, mitochondrial
Synonyms: LOC382117, D9Ertd402e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382117
Homologene: 45481
Prdm14
Name: PR domain containing 14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383491
Homologene: 11556
Scd2
Name: stearoyl-Coenzyme A desaturase 2
Synonyms: Scd-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20250
VEGA: 19
Homologene: 136612
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Tmem62
Name: transmembrane protein 62
Synonyms: B830009D23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 96957
Homologene: 11801
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Birc1f, Naip-rs4A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhs-f, MyHC-IIa, MHC2A, Myhsf1, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2A, Sur2, SUR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Ccdc148
Name: coiled-coil domain containing 148
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227933
Homologene: 16353
Krt81
Name: keratin 81
Synonyms: Krt2-19
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64818
VEGA: 15
HGNC: HGNC:6458
Homologene: 55645
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246317
VEGA: 18
Homologene: 16367
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384534
Homologene: 129605
Spata7
Name: spermatogenesis associated 7
Synonyms: B230306G18Rik, HSD3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104871
Homologene: 10189
Pramel15
Name: PRAME like 15
Synonyms: Gm13125, Pramef20, EG627009
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627009
Homologene: 133194
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241158
Homologene: 9561
Tbpl2
Name: TATA box binding protein like 2
Synonyms: Trf3, LOC227606
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227606
Homologene: 133152
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384221
Homologene: 104825
Slc23a2
Name: solute carrier family 23 (nucleobase transporters), member 2
Synonyms: SVCT2, Slc23a1, YSPL3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54338
Homologene: 68440
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Abhd12
Name: abhydrolase domain containing 12
Synonyms: 1500011G07Rik, 6330583M11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76192
Homologene: 22910
Cfap157
Name: cilia and flagella associated protein 157
Synonyms: 1700019L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227736
Homologene: 53056
Arhgap18
Name: Rho GTPase activating protein 18
Synonyms: 4833419J07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73910
Homologene: 14135
Tpp1
Name: tripeptidyl peptidase I
Synonyms: Cln2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12751
HGNC: HGNC:2073
Homologene: 335
Or52e8
Name: olfactory receptor family 52 subfamily E member 8
Synonyms: MOR32-12, GA_x6K02T2PBJ9-7604826-7603885, Olfr671
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257910
Homologene: 133595
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: WARP, 4932416A11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246228
Homologene: 11270
Tafa4
Name: TAFA chemokine like family member 4
Synonyms: Tafa4, C130034I18Rik, Fam19a4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320701
Homologene: 18561
Ccdc24
Name: coiled-coil domain containing 24
Synonyms: LOC381546
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381546
Armc7
Name: armadillo repeat containing 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276905
Homologene: 11603
Cyp2ab1
Name: cytochrome P450, family 2, subfamily ab, polypeptide 1
Synonyms: EG224044
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224044
Homologene: 120487
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 13,122,433 bp (GRCm38)
  • A to G, chromosome 1 at 92,877,051 bp (GRCm38)
  • G to T, chromosome 1 at 93,190,495 bp (GRCm38)
  • A to G, chromosome 1 at 144,002,088 bp (GRCm38)
  • A to T, chromosome 1 at 163,976,771 bp (GRCm38)
  • A to G, chromosome 2 at 24,087,284 bp (GRCm38)
  • T to C, chromosome 2 at 32,779,741 bp (GRCm38)
  • A to T, chromosome 2 at 59,003,385 bp (GRCm38)
  • T to A, chromosome 2 at 69,430,359 bp (GRCm38)
  • T to C, chromosome 2 at 120,999,086 bp (GRCm38)
  • C to A, chromosome 2 at 125,345,986 bp (GRCm38)
  • C to A, chromosome 2 at 132,062,178 bp (GRCm38)
  • T to C, chromosome 2 at 150,846,278 bp (GRCm38)
  • A to G, chromosome 3 at 65,531,280 bp (GRCm38)
  • A to T, chromosome 3 at 97,210,007 bp (GRCm38)
  • A to G, chromosome 4 at 117,872,151 bp (GRCm38)
  • A to T, chromosome 4 at 144,376,956 bp (GRCm38)
  • G to A, chromosome 4 at 155,772,879 bp (GRCm38)
  • A to G, chromosome 5 at 57,719,855 bp (GRCm38)
  • A to G, chromosome 5 at 96,740,692 bp (GRCm38)
  • A to G, chromosome 5 at 109,427,803 bp (GRCm38)
  • A to G, chromosome 6 at 97,014,468 bp (GRCm38)
  • C to A, chromosome 6 at 123,139,332 bp (GRCm38)
  • T to C, chromosome 6 at 142,633,087 bp (GRCm38)
  • A to T, chromosome 7 at 10,170,792 bp (GRCm38)
  • A to G, chromosome 7 at 104,975,206 bp (GRCm38)
  • A to T, chromosome 7 at 105,747,507 bp (GRCm38)
  • T to C, chromosome 7 at 118,213,047 bp (GRCm38)
  • G to T, chromosome 7 at 127,522,047 bp (GRCm38)
  • A to C, chromosome 7 at 128,676,791 bp (GRCm38)
  • A to G, chromosome 9 at 122,808,765 bp (GRCm38)
  • T to A, chromosome 10 at 26,912,659 bp (GRCm38)
  • G to A, chromosome 11 at 20,238,506 bp (GRCm38)
  • G to T, chromosome 11 at 59,136,183 bp (GRCm38)
  • G to A, chromosome 11 at 67,173,476 bp (GRCm38)
  • A to G, chromosome 11 at 115,488,886 bp (GRCm38)
  • T to A, chromosome 12 at 98,634,300 bp (GRCm38)
  • C to A, chromosome 13 at 65,073,600 bp (GRCm38)
  • T to C, chromosome 13 at 100,300,138 bp (GRCm38)
  • G to T, chromosome 14 at 50,863,008 bp (GRCm38)
  • T to C, chromosome 15 at 9,599,811 bp (GRCm38)
  • T to C, chromosome 15 at 101,461,038 bp (GRCm38)
  • A to T, chromosome 16 at 20,316,590 bp (GRCm38)
  • T to C, chromosome 18 at 45,683,082 bp (GRCm38)
  • G to T, chromosome 18 at 46,505,295 bp (GRCm38)
  • T to C, chromosome 18 at 86,404,696 bp (GRCm38)
  • C to A, chromosome 19 at 44,299,807 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9597 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069390-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.