Strain Name:
C57BL/6J-MtgxR9677Btlr/Mmmh
Stock Number:
069470-MU
Citation ID:
RRID:MMRRC_069470-MU
Other Names:
R9677 (G1)
Major Collection:

Strain Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57138
Homologene: 10665
Med26
Name: mediator complex subunit 26
Synonyms: Crsp7, 5730493L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70625
HGNC: HGNC:2376
Homologene: 68417
Rab30
Name: RAB30, member RAS oncogene family
Synonyms: 5033421K01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75985
HGNC: HGNC:9770
Homologene: 22815
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, MYM, RAMP, FIM, Zfp198
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Ddx52
Name: DExD box helicase 52
Synonyms: 2700029C06Rik, ROK1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78394
Homologene: 5093
Cisd2
Name: CDGSH iron sulfur domain 2
Synonyms: 1500009M05Rik, Zcd2, Miner1, B630006A20Rik, 1500026J14Rik, 1500031D15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67006
Homologene: 36436
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ift122
Name: intraflagellar transport 122
Synonyms: sopb, Wdr10, C86139
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 81896
Homologene: 12819
Tfrc
Name: transferrin receptor
Synonyms: Mtvr-1, TfR1, Mtvr1, p90, CD71, 2610028K12Rik, E430033M20Rik, Trfr
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22042
Homologene: 2429
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
Nup50
Name: nucleoporin 50
Synonyms: 1700030K07Rik, Npap60
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18141
VEGA: 15
HGNC: HGNC:8065
Homologene: 5190
Ctps1
Name: cytidine 5'-triphosphate synthase 1
Synonyms: Ctps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51797
HGNC: HGNC:2519
Homologene: 20446
Rbis
Name: ribosomal biogenesis factor
Synonyms: 1810022K09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69126
Homologene: 47794
Fam169b
Name: family with sequence similarity 169, member B
Synonyms: EG434197
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434197
Homologene: 79038
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: E030034C22Rik, Dnahc1, G1-415-19, MDHC7, ferf1, B230373P09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Hspa1b
Name: heat shock protein 1B
Synonyms: Hsp70.1, HSP70B1, hsp68, Hsp70-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15511
HGNC: HGNC:5233
Homologene: 133785
Chmp6
Name: charged multivesicular body protein 6
Synonyms: 2400004G01Rik, chromatin modifying protein 6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208092
Homologene: 11607
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: MOR202-24, GA_x6K02T2RE5P-3430689-3429787, EG667271, Olfr1458
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Actc1
Name: actin, alpha, cardiac muscle 1
Synonyms: alphac-actin, Actc-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11464
HGNC: HGNC:143
Homologene: 68446
Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
Synonyms: Ask2, MEKK6, MAPKKK6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53608
HGNC: HGNC:6858
Homologene: 3435
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4930432K16Rik, 4921529O18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78257
Homologene: 12692
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384219
Homologene: 129606
Tmem220
Name: transmembrane protein 220
Synonyms: A730055C05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338369
Homologene: 18579
Btnl2
Name: butyrophilin-like 2
Synonyms: BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Zdhhc2
Name: zinc finger, DHHC domain containing 2
Synonyms: 6430583A19Rik, 5730415P04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70546
Homologene: 81667
Or4a81
Name: olfactory receptor family 4 subfamily A member 81
Synonyms: MOR231-13, Olfr1254, GA_x6K02T2Q125-51230155-51229211
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258468
Homologene: 103784
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 45,330,567 bp (GRCm38)
  • A to T, chromosome 2 at 89,788,817 bp (GRCm38)
  • T to C, chromosome 2 at 114,048,155 bp (GRCm38)
  • A to G, chromosome 2 at 164,992,326 bp (GRCm38)
  • A to G, chromosome 3 at 14,609,614 bp (GRCm38)
  • T to A, chromosome 3 at 135,423,283 bp (GRCm38)
  • G to T, chromosome 4 at 120,552,895 bp (GRCm38)
  • G to T, chromosome 4 at 133,241,116 bp (GRCm38)
  • G to A, chromosome 5 at 86,118,051 bp (GRCm38)
  • T to C, chromosome 5 at 109,053,466 bp (GRCm38)
  • T to A, chromosome 6 at 115,920,396 bp (GRCm38)
  • A to G, chromosome 7 at 68,304,640 bp (GRCm38)
  • G to A, chromosome 7 at 92,820,037 bp (GRCm38)
  • T to A, chromosome 8 at 40,456,671 bp (GRCm38)
  • A to T, chromosome 8 at 72,496,086 bp (GRCm38)
  • T to A, chromosome 9 at 86,543,045 bp (GRCm38)
  • T to C, chromosome 10 at 5,265,125 bp (GRCm38)
  • T to C, chromosome 10 at 79,148,838 bp (GRCm38)
  • G to T, chromosome 11 at 67,034,185 bp (GRCm38)
  • A to G, chromosome 11 at 83,946,120 bp (GRCm38)
  • C to T, chromosome 11 at 119,915,633 bp (GRCm38)
  • T to C, chromosome 12 at 72,450,765 bp (GRCm38)
  • T to C, chromosome 14 at 31,307,864 bp (GRCm38)
  • T to C, chromosome 14 at 56,949,658 bp (GRCm38)
  • A to G, chromosome 15 at 84,935,278 bp (GRCm38)
  • A to G, chromosome 16 at 32,615,361 bp (GRCm38)
  • T to A, chromosome 17 at 34,361,033 bp (GRCm38)
  • C to T, chromosome 17 at 34,698,904 bp (GRCm38)
  • C to A, chromosome 17 at 34,958,884 bp (GRCm38)
  • T to A, chromosome 19 at 13,103,154 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9677 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069470-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.