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Strain Name:
C57BL/6J-MtgxR9685Btlr/Mmmh
Stock Number:
069478-MU
Citation ID:
RRID:MMRRC_069478-MU
Other Names:
R9685 (G1)
Major Collection:

Strain Information

Dnajc3
Name: DnaJ heat shock protein family (Hsp40) member C3
Synonyms: p58IPK, mp58, Prkri, Dnajc3, Dnajc3a, Dnajc3b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100037258
VEGA: 14
HGNC: HGNC:9439
Homologene: 2486
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Cdk13
Name: cyclin dependent kinase 13
Synonyms: 2310015O17Rik, Cdc2l5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: B930007L02Rik, Vprbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Elovl5
Name: ELOVL fatty acid elongase 5
Synonyms: 1110059L23Rik, ELOVL family member 5, elongation of long chain fatty acids (yeast)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68801
Homologene: 41449
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 9,546,165 bp (GRCm38)
  • C to T, chromosome 1 at 10,126,414 bp (GRCm38)
  • T to C, chromosome 1 at 174,205,359 bp (GRCm38)
  • G to A, chromosome 1 at 193,174,757 bp (GRCm38)
  • T to C, chromosome 2 at 85,689,522 bp (GRCm38)
  • C to A, chromosome 2 at 120,021,183 bp (GRCm38)
  • T to A, chromosome 3 at 10,328,370 bp (GRCm38)
  • A to G, chromosome 3 at 64,556,660 bp (GRCm38)
  • T to A, chromosome 3 at 116,499,576 bp (GRCm38)
  • T to C, chromosome 3 at 123,117,717 bp (GRCm38)
  • A to G, chromosome 4 at 139,464,030 bp (GRCm38)
  • T to A, chromosome 4 at 143,992,950 bp (GRCm38)
  • AACT to A, chromosome 5 at 25,950,851 bp (GRCm38)
  • A to G, chromosome 5 at 45,453,989 bp (GRCm38)
  • T to C, chromosome 5 at 73,059,536 bp (GRCm38)
  • A to G, chromosome 5 at 96,082,890 bp (GRCm38)
  • A to G, chromosome 5 at 109,292,732 bp (GRCm38)
  • A to T, chromosome 5 at 125,294,130 bp (GRCm38)
  • A to G, chromosome 5 at 135,449,822 bp (GRCm38)
  • A to G, chromosome 5 at 136,095,529 bp (GRCm38)
  • T to G, chromosome 6 at 43,273,593 bp (GRCm38)
  • T to C, chromosome 6 at 57,390,478 bp (GRCm38)
  • T to C, chromosome 6 at 124,311,425 bp (GRCm38)
  • G to A, chromosome 7 at 44,257,309 bp (GRCm38)
  • CGGC to CGGCGGCGGGGGC, chromosome 7 at 97,579,932 bp (GRCm38)
  • A to T, chromosome 8 at 79,996,734 bp (GRCm38)
  • T to C, chromosome 8 at 106,010,101 bp (GRCm38)
  • A to T, chromosome 9 at 55,864,551 bp (GRCm38)
  • T to G, chromosome 9 at 56,890,338 bp (GRCm38)
  • T to C, chromosome 9 at 77,961,009 bp (GRCm38)
  • T to C, chromosome 9 at 88,957,132 bp (GRCm38)
  • C to T, chromosome 9 at 106,836,619 bp (GRCm38)
  • T to C, chromosome 10 at 10,689,031 bp (GRCm38)
  • A to G, chromosome 10 at 77,715,928 bp (GRCm38)
  • A to C, chromosome 11 at 100,383,411 bp (GRCm38)
  • A to C, chromosome 11 at 116,596,855 bp (GRCm38)
  • T to C, chromosome 12 at 73,970,341 bp (GRCm38)
  • C to A, chromosome 13 at 17,803,957 bp (GRCm38)
  • A to T, chromosome 13 at 92,522,803 bp (GRCm38)
  • G to A, chromosome 14 at 34,355,309 bp (GRCm38)
  • A to T, chromosome 14 at 118,972,363 bp (GRCm38)
  • T to A, chromosome 15 at 94,553,931 bp (GRCm38)
  • G to T, chromosome 16 at 64,766,460 bp (GRCm38)
  • G to A, chromosome 18 at 20,099,030 bp (GRCm38)
  • T to A, chromosome 19 at 8,852,055 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9685 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069478-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.