Strain Name:
C57BL/6J-MtgxR9703Btlr/Mmmh
Stock Number:
069496-MU
Citation ID:
RRID:MMRRC_069496-MU
Other Names:
R9703 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22222
Homologene: 7582
Swap70
Name: SWA-70 protein
Synonyms: 70kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20947
Homologene: 7557
Btbd9
Name: BTB domain containing 9
Synonyms: 1700023F20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224671
VEGA: 17
Homologene: 14995
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Ddx46
Name: DEAD box helicase 46
Synonyms: 8430438J23Rik, 2200005K02Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212880
VEGA: 13
Homologene: 5430
Slc25a17
Name: solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
Synonyms: 34kDa, PMP34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20524
VEGA: 15
Homologene: 4637
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: 3110039B05Rik, Bat-2, Bat2, G2, D17H6S51E, Wbp12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53761
Homologene: 10567
Srsf10
Name: serine and arginine-rich splicing factor 10
Synonyms: TASR1, FUSIP2, SRrp40, NSSR1, NSSR2, Sfrs13a, Srsf13a, TASR2, Nssr, Fusip1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14105
Homologene: 134051
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: 8430435B07Rik, LOC237436
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Ints13
Name: integrator complex subunit 13
Synonyms: Spata30, Asun, 4933424B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71177
Homologene: 10043
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 73473
Homologene: 134421
Efs
Name: embryonal Fyn-associated substrate
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13644
VEGA: 14
Homologene: 4284
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Tnc
Name: tenascin C
Synonyms: C130033P17Rik, TN, hexabrachion, Hxb, cytotactin, tenascin-C, TN-C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Extl3
Name: exostosin-like glycosyltransferase 3
Synonyms: 2900009G18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54616
VEGA: 14
HGNC: HGNC:3518
Homologene: 1103
Golm1
Name: golgi membrane protein 1
Synonyms: Golph2, GP73, PSEC0257, D030064E01Rik, 2310001L02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: 3110009N10Rik, BACH1, 8030460J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237911
Homologene: 32766
Smpd3
Name: sphingomyelin phosphodiesterase 3, neutral
Synonyms: fro, neutral sphingomyelinase II, nSMase2, Nsm2, 4631433G07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58994
Homologene: 10260
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Arhgap30
Name: Rho GTPase activating protein 30
Synonyms: 6030405P05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226652
Homologene: 18766
Syde1
Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms: 1200008N06Rik, mSYD1A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71709
VEGA: 10
Homologene: 13195
Dock10
Name: dedicator of cytokinesis 10
Synonyms: A630054M16Rik, Zizimin3, Jr5, Jr4, ZIZ3, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Prph2
Name: peripherin 2
Synonyms: Tspan22, Rd2, rds, Nmf193
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19133
HGNC: HGNC:9942
Homologene: 273
Esyt1
Name: extended synaptotagmin-like protein 1
Synonyms: vp115, Mbc2, Fam62a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23943
VEGA: 10
Homologene: 40794
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234135
Homologene: 56960
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Hrh1
Name: histamine receptor H1
Synonyms: Hir, Bphs
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15465
HGNC: HGNC:5182
Homologene: 668
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Tha1
Name: threonine aldolase 1
Synonyms: 1300017K07Rik, GLY1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71776
Homologene: 57081
Pramel29
Name: PRAME like 29
Synonyms: C87977
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 97187
Homologene: 103830
Or6c214
Name: olfactory receptor family 6 subfamily C member 214
Synonyms: MOR117-1, Olfr807, GA_x6K02T2PULF-11434134-11433199
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258931
Homologene: 27300
Cts7
Name: cathepsin 7
Synonyms: CTS1, Epcs71, Epcs24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56092
VEGA: 13
Homologene: 75110
Or2n1b
Name: olfactory receptor family 2 subfamily N member 1B
Synonyms: Olfr133, GA_x6K02T2PSCP-2597192-2598130, MOR256-6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258828
Homologene: 110603
Klrc2
Name: killer cell lectin-like receptor subfamily C, member 2
Synonyms: NKG2C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16642
Homologene: 130643
Kcnrg
Name: potassium channel regulator
Synonyms: E030012H22Rik, LOC328424
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328424
VEGA: 14
Homologene: 35259
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: WARP, 4932416A11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246228
Homologene: 11270
Pals1
Name: protein associated with LIN7 1, MAGUK family member
Synonyms: Pals1, 3830420B02Rik, Mpp5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56217
VEGA: 12
Homologene: 9512
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76877
HGNC: HGNC:9775
Homologene: 3610
Grxcr2
Name: glutaredoxin, cysteine rich 2
Synonyms: LOC332309
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 332309
VEGA: 18
Homologene: 85304
Twist2
Name: twist basic helix-loop-helix transcription factor 2
Synonyms: Dermo1, bHLHa39
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13345
Homologene: 40594
H2ac19
Name: H2A clustered histone 19
Synonyms: H2a-614, Hist2h2aa2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319192
Homologene: 116071
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 75,185,787 bp (GRCm38)
  • G to A, chromosome 1 at 80,539,823 bp (GRCm38)
  • C to A, chromosome 1 at 91,802,022 bp (GRCm38)
  • C to A, chromosome 1 at 93,202,722 bp (GRCm38)
  • T to A, chromosome 1 at 161,970,607 bp (GRCm38)
  • T to G, chromosome 1 at 171,407,771 bp (GRCm38)
  • C to T, chromosome 2 at 120,901,611 bp (GRCm38)
  • G to A, chromosome 3 at 96,240,241 bp (GRCm38)
  • G to A, chromosome 4 at 63,971,175 bp (GRCm38)
  • A to G, chromosome 4 at 135,863,842 bp (GRCm38)
  • T to A, chromosome 4 at 144,212,940 bp (GRCm38)
  • G to A, chromosome 4 at 155,772,879 bp (GRCm38)
  • A to G, chromosome 5 at 142,114,528 bp (GRCm38)
  • A to G, chromosome 6 at 48,932,695 bp (GRCm38)
  • G to A, chromosome 6 at 114,481,018 bp (GRCm38)
  • G to C, chromosome 6 at 129,656,444 bp (GRCm38)
  • A to T, chromosome 6 at 146,557,565 bp (GRCm38)
  • G to A, chromosome 7 at 28,106,975 bp (GRCm38)
  • T to A, chromosome 7 at 107,784,570 bp (GRCm38)
  • C to T, chromosome 7 at 110,273,305 bp (GRCm38)
  • A to T, chromosome 7 at 118,140,521 bp (GRCm38)
  • A to G, chromosome 7 at 141,871,798 bp (GRCm38)
  • T to C, chromosome 8 at 25,641,212 bp (GRCm38)
  • T to A, chromosome 8 at 40,795,934 bp (GRCm38)
  • T to A, chromosome 8 at 106,265,081 bp (GRCm38)
  • T to C, chromosome 9 at 67,386,656 bp (GRCm38)
  • T to C, chromosome 10 at 75,050,642 bp (GRCm38)
  • T to A, chromosome 10 at 77,990,308 bp (GRCm38)
  • G to T, chromosome 10 at 78,585,723 bp (GRCm38)
  • C to T, chromosome 10 at 89,414,081 bp (GRCm38)
  • C to T, chromosome 10 at 128,518,927 bp (GRCm38)
  • A to T, chromosome 10 at 129,755,417 bp (GRCm38)
  • T to C, chromosome 11 at 86,062,004 bp (GRCm38)
  • A to G, chromosome 11 at 117,871,037 bp (GRCm38)
  • T to A, chromosome 12 at 7,980,507 bp (GRCm38)
  • T to A, chromosome 12 at 78,797,076 bp (GRCm38)
  • A to G, chromosome 13 at 55,676,822 bp (GRCm38)
  • A to T, chromosome 13 at 59,649,619 bp (GRCm38)
  • T to C, chromosome 13 at 61,356,536 bp (GRCm38)
  • A to T, chromosome 14 at 54,919,414 bp (GRCm38)
  • CACAACAA to CACAA, chromosome 14 at 61,607,560 bp (GRCm38)
  • G to T, chromosome 14 at 65,054,654 bp (GRCm38)
  • A to T, chromosome 14 at 121,544,577 bp (GRCm38)
  • A to T, chromosome 15 at 81,339,992 bp (GRCm38)
  • C to G, chromosome 16 at 59,555,576 bp (GRCm38)
  • A to G, chromosome 17 at 30,530,226 bp (GRCm38)
  • T to C, chromosome 17 at 35,159,344 bp (GRCm38)
  • A to T, chromosome 17 at 38,148,965 bp (GRCm38)
  • G to A, chromosome 17 at 46,923,521 bp (GRCm38)
  • T to A, chromosome 18 at 32,079,685 bp (GRCm38)
  • T to A, chromosome 18 at 37,265,966 bp (GRCm38)
  • T to C, chromosome 18 at 41,991,923 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9703 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069496-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.