Strain Name:
C57BL/6J-MtgxR9725Btlr/Mmmh
Stock Number:
069971-MU
Citation ID:
RRID:MMRRC_069971-MU
Other Names:
R9725 (G1)
Major Collection:

Strain Information

Vps33a
Name: VPS33A CORVET/HOPS core subunit
Synonyms: bf, 3830421M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77573
Homologene: 11294
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Dlg1
Name: discs large MAGUK scaffold protein 1
Synonyms: Dlgh1, SAP97, B130052P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13383
HGNC: HGNC:2900
Homologene: 20869
Tti1
Name: TELO2 interacting protein 1
Synonyms: 2610036D13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75425
Homologene: 40969
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22771
Homologene: 2562
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Rob, Mllt2h, 9630032B01Rik, Af4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: Fubp4, Fubp, 9530027K12Rik, FBP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Layn
Name: layilin
Synonyms: E030012M19Rik, LOC244864
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244864
VEGA: 9
Homologene: 18716
Ms4a14
Name: membrane-spanning 4-domains, subfamily A, member 14
Synonyms: LOC383435
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 383435
Homologene: 138453
Nxn
Name: nucleoredoxin
Synonyms: l11Jus13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18230
Homologene: 69028
Prcp
Name: prolylcarboxypeptidase (angiotensinase C)
Synonyms: 2510048K03Rik, 2610104A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72461
HGNC: HGNC:9344
Homologene: 55867
Tmc2
Name: transmembrane channel-like gene family 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192140
Homologene: 25877
Krt14
Name: keratin 14
Synonyms: Krt-1.14, K14, Krt1-14, epidermolysis bullosa simplex, Dowling-Meara, Koebner, Cytokeratin 14
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16664
HGNC: HGNC:6416
Homologene: 110439
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Gm12695
Name: predicted gene 12695
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 620779
Homologene: 51847
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242838
Homologene: 18247
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: MOR202-24, GA_x6K02T2RE5P-3430689-3429787, EG667271, Olfr1458
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Pcdhb22
Name: protocadherin beta 22
Synonyms: PcdhbV, Pcdhb15
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Synonyms: OATP-B, Slc21a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101488
Homologene: 21419
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, PLCeta2, Plcl4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Lrrtm2
Name: leucine rich repeat transmembrane neuronal 2
Synonyms: C630011A14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107065
VEGA: 18
Homologene: 65342
Styk1
Name: serine/threonine/tyrosine kinase 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243659
Homologene: 49545
Slc39a10
Name: solute carrier family 39 (zinc transporter), member 10
Synonyms: 2900042E17Rik, Zip10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227059
Homologene: 34076
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: CD106, Vcam-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22329
Homologene: 838
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mrp1, Abcc1a, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Klra10
Name: killer cell lectin-like receptor subfamily A, member 10
Synonyms: Ly49J, Ly49i2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16628
Homologene: 110821
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Gm101, Pcdp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226356
Homologene: 88578
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Kcnj13
Name: potassium inwardly-rectifying channel, subfamily J, member 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040591
HGNC: HGNC:6259
Homologene: 55638
Or3a1b
Name: olfactory receptor family 3 subfamily A member 1B
Synonyms: MOR255-6, GA_x6K02T2P1NL-4278037-4278984, Olfr401
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258701
HGNC: HGNC:8282
Homologene: 73922
Rgs20
Name: regulator of G-protein signaling 20
Synonyms: Rgsz1, 2900073E09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 58175
Homologene: 2745
Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226646
HGNC: HGNC:7708
Homologene: 56659
Vmn1r238
Name: vomeronasal 1 receptor, 238
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100312476
Homologene: 128342
Gkn1
Name: gastrokine 1
Synonyms: BRICD1, AMP-18, 2200002K21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66283
Homologene: 10487
Or6aa1
Name: olfactory receptor family 6 subfamily AA member 1
Synonyms: GA_x6K02T2NHDJ-9712819-9713778, Olfr303, MOR104-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258612
Homologene: 105157
Vmn1r211
Name: vomeronasal 1 receptor 211
Synonyms: V1rh20
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171277
Homologene: 110880
Carns1
Name: carnosine synthase 1
Synonyms: Atpgd1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107239
VEGA: 19
Homologene: 26439
Camk2b
Name: calcium/calmodulin-dependent protein kinase II, beta
Synonyms: CaMK II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12323
HGNC: HGNC:1461
Homologene: 111050
Fahd2a
Name: fumarylacetoacetate hydrolase domain containing 2A
Synonyms: B430104H02Rik, 1500003K14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68126
Homologene: 131290
Fn3k
Name: fructosamine 3 kinase
Synonyms: 2310074G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 63828
Homologene: 23336
Trav16n
Name: T cell receptor alpha variable 16n
Synonyms: Gm16837
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126459
Kif19b
Name: kinesin family member 19B
Synonyms: Gm4869
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101055939
Homologene: 82478
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 4,910,570 bp (GRCm38)
  • A to G, chromosome 1 at 46,810,063 bp (GRCm38)
  • G to T, chromosome 1 at 87,387,015 bp (GRCm38)
  • G to T, chromosome 1 at 119,934,622 bp (GRCm38)
  • A to G, chromosome 1 at 171,247,060 bp (GRCm38)
  • T to C, chromosome 2 at 127,436,384 bp (GRCm38)
  • T to A, chromosome 2 at 130,247,961 bp (GRCm38)
  • C to T, chromosome 2 at 158,007,384 bp (GRCm38)
  • C to T, chromosome 3 at 116,128,638 bp (GRCm38)
  • T to A, chromosome 3 at 152,222,186 bp (GRCm38)
  • A to G, chromosome 4 at 96,728,229 bp (GRCm38)
  • T to C, chromosome 4 at 155,000,535 bp (GRCm38)
  • A to G, chromosome 5 at 3,851,147 bp (GRCm38)
  • A to T, chromosome 5 at 103,847,065 bp (GRCm38)
  • A to T, chromosome 5 at 123,531,072 bp (GRCm38)
  • G to A, chromosome 5 at 140,474,896 bp (GRCm38)
  • A to G, chromosome 6 at 87,346,307 bp (GRCm38)
  • A to G, chromosome 6 at 113,409,153 bp (GRCm38)
  • T to C, chromosome 6 at 126,534,881 bp (GRCm38)
  • C to T, chromosome 6 at 130,275,886 bp (GRCm38)
  • GTCTCTTCATGATT to GT, chromosome 6 at 131,301,647 bp (GRCm38)
  • CTCTTCATGATTTTCTT to CTCTT, chromosome 6 at 131,301,649 bp (GRCm38)
  • A to C, chromosome 7 at 86,394,765 bp (GRCm38)
  • G to T, chromosome 7 at 92,917,827 bp (GRCm38)
  • A to G, chromosome 7 at 99,686,058 bp (GRCm38)
  • T to C, chromosome 9 at 51,057,475 bp (GRCm38)
  • A to G, chromosome 9 at 91,364,822 bp (GRCm38)
  • T to A, chromosome 10 at 60,596,782 bp (GRCm38)
  • T to C, chromosome 11 at 5,972,634 bp (GRCm38)
  • A to G, chromosome 11 at 74,121,786 bp (GRCm38)
  • T to C, chromosome 11 at 76,278,536 bp (GRCm38)
  • T to C, chromosome 11 at 100,207,076 bp (GRCm38)
  • T to A, chromosome 11 at 121,450,365 bp (GRCm38)
  • T to C, chromosome 13 at 22,852,336 bp (GRCm38)
  • A to T, chromosome 13 at 100,222,276 bp (GRCm38)
  • A to G, chromosome 14 at 53,351,102 bp (GRCm38)
  • T to G, chromosome 16 at 14,472,933 bp (GRCm38)
  • T to G, chromosome 16 at 31,846,865 bp (GRCm38)
  • A to G, chromosome 18 at 3,122,577 bp (GRCm38)
  • A to G, chromosome 18 at 35,212,735 bp (GRCm38)
  • G to T, chromosome 18 at 37,519,741 bp (GRCm38)
  • A to G, chromosome 18 at 74,723,770 bp (GRCm38)
  • A to G, chromosome 19 at 4,166,549 bp (GRCm38)
  • A to G, chromosome 19 at 6,404,664 bp (GRCm38)
  • A to G, chromosome 19 at 6,413,877 bp (GRCm38)
  • A to G, chromosome 19 at 9,004,169 bp (GRCm38)
  • T to A, chromosome 19 at 9,014,243 bp (GRCm38)
  • A to T, chromosome 19 at 11,303,365 bp (GRCm38)
  • G to A, chromosome 19 at 13,102,908 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9725 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069971-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.