Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR9725Btlr/Mmmh
Stock Number:
069971-MU
Citation ID:
RRID:MMRRC_069971-MU
Other Names:
R9725 (G1)
Major Collection:

Strain Information

Vps33a
Name: VPS33A CORVET/HOPS core subunit
Synonyms: bf, 3830421M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77573
Homologene: 11294
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Dlg1
Name: discs large MAGUK scaffold protein 1
Synonyms: B130052P05Rik, SAP97, Dlgh1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13383
HGNC: HGNC:2900
Homologene: 20869
Tti1
Name: TELO2 interacting protein 1
Synonyms: 2610036D13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75425
Homologene: 40969
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22771
Homologene: 2562
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Af4, Rob, 9630032B01Rik, Mllt2h
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: FBP, Fubp, Fubp4, 9530027K12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 4,910,570 bp (GRCm38)
  • A to G, chromosome 1 at 46,810,063 bp (GRCm38)
  • G to T, chromosome 1 at 87,387,015 bp (GRCm38)
  • G to T, chromosome 1 at 119,934,622 bp (GRCm38)
  • A to G, chromosome 1 at 171,247,060 bp (GRCm38)
  • T to C, chromosome 2 at 127,436,384 bp (GRCm38)
  • T to A, chromosome 2 at 130,247,961 bp (GRCm38)
  • C to T, chromosome 2 at 158,007,384 bp (GRCm38)
  • C to T, chromosome 3 at 116,128,638 bp (GRCm38)
  • T to A, chromosome 3 at 152,222,186 bp (GRCm38)
  • A to G, chromosome 4 at 96,728,229 bp (GRCm38)
  • T to C, chromosome 4 at 155,000,535 bp (GRCm38)
  • A to G, chromosome 5 at 3,851,147 bp (GRCm38)
  • A to T, chromosome 5 at 103,847,065 bp (GRCm38)
  • A to T, chromosome 5 at 123,531,072 bp (GRCm38)
  • G to A, chromosome 5 at 140,474,896 bp (GRCm38)
  • A to G, chromosome 6 at 87,346,307 bp (GRCm38)
  • A to G, chromosome 6 at 113,409,153 bp (GRCm38)
  • T to C, chromosome 6 at 126,534,881 bp (GRCm38)
  • C to T, chromosome 6 at 130,275,886 bp (GRCm38)
  • GTCTCTTCATGATT to GT, chromosome 6 at 131,301,647 bp (GRCm38)
  • CTCTTCATGATTTTCTT to CTCTT, chromosome 6 at 131,301,649 bp (GRCm38)
  • A to C, chromosome 7 at 86,394,765 bp (GRCm38)
  • G to T, chromosome 7 at 92,917,827 bp (GRCm38)
  • A to G, chromosome 7 at 99,686,058 bp (GRCm38)
  • T to C, chromosome 9 at 51,057,475 bp (GRCm38)
  • A to G, chromosome 9 at 91,364,822 bp (GRCm38)
  • T to A, chromosome 10 at 60,596,782 bp (GRCm38)
  • T to C, chromosome 11 at 5,972,634 bp (GRCm38)
  • A to G, chromosome 11 at 74,121,786 bp (GRCm38)
  • T to C, chromosome 11 at 76,278,536 bp (GRCm38)
  • T to C, chromosome 11 at 100,207,076 bp (GRCm38)
  • T to A, chromosome 11 at 121,450,365 bp (GRCm38)
  • T to C, chromosome 13 at 22,852,336 bp (GRCm38)
  • A to T, chromosome 13 at 100,222,276 bp (GRCm38)
  • A to G, chromosome 14 at 53,351,102 bp (GRCm38)
  • T to G, chromosome 16 at 14,472,933 bp (GRCm38)
  • T to G, chromosome 16 at 31,846,865 bp (GRCm38)
  • A to G, chromosome 18 at 3,122,577 bp (GRCm38)
  • A to G, chromosome 18 at 35,212,735 bp (GRCm38)
  • G to T, chromosome 18 at 37,519,741 bp (GRCm38)
  • A to G, chromosome 18 at 74,723,770 bp (GRCm38)
  • A to G, chromosome 19 at 4,166,549 bp (GRCm38)
  • A to G, chromosome 19 at 6,404,664 bp (GRCm38)
  • A to G, chromosome 19 at 6,413,877 bp (GRCm38)
  • A to G, chromosome 19 at 9,004,169 bp (GRCm38)
  • T to A, chromosome 19 at 9,014,243 bp (GRCm38)
  • A to T, chromosome 19 at 11,303,365 bp (GRCm38)
  • G to A, chromosome 19 at 13,102,908 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9725 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069971-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.