Strain Name:
C57BL/6J-MtgxR9750Btlr/Mmmh
Stock Number:
069996-MU
Citation ID:
RRID:MMRRC_069996-MU
Other Names:
R9750 (G1)
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: 2610509D04Rik, Ggtb3, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Fbxo38
Name: F-box protein 38
Synonyms: SP329, 6030410I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107035
VEGA: 18
Homologene: 34526
Anapc2
Name: anaphase promoting complex subunit 2
Synonyms: expressed during mesenchymal induction 4, Emi4, APC2, 9230107K09Rik, Imi4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99152
Homologene: 8359
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
Ap5m1
Name: adaptor-related protein complex 5, mu 1 subunit
Synonyms: 4932432K03Rik, Mudeng
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74385
VEGA: 14
Homologene: 10081
Amotl1
Name: angiomotin-like 1
Synonyms: 4932416D09Rik, JEAP, 2310067L22Rik, 2310010G08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75723
Homologene: 43977
Pgr
Name: progesterone receptor
Synonyms: PR, NR3C3, 9930019P03Rik, PR-B, PR-A, ENSMUSG00000074510
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Zfp960
Name: zinc finger protein 960
Synonyms: BC018101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 449000
Homologene: 133884
Mon1a
Name: MON1 homolog A, secretory traffciking associated
Synonyms: 2810468K17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72825
Homologene: 7191
Esco1
Name: establishment of sister chromatid cohesion N-acetyltransferase 1
Synonyms: A930014I12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77805
Homologene: 62166
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229473
Homologene: 9057
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Ltbr
Name: lymphotoxin B receptor
Synonyms: TNFRrp, TNF receptor-related protein, LT-beta receptor, LT beta-R, Tnfbr, Ltar, TNF-R-III, TNFCR, TNFR2-RP, LTbetaR, Tnfrsf3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Pdzd8
Name: PDZ domain containing 8
Synonyms: A630041P07Rik, Pdzk8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Serpina3j
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J
Synonyms: alpha-1 antiproteinase, Gm4931
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238395
HGNC: HGNC:16
Homologene: 120222
Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2
Synonyms: ADAM-TS2, hPCPNI, a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Kansl1l
Name: KAT8 regulatory NSL complex subunit 1-like
Synonyms: C430010P07Rik, 1110028C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68691
Homologene: 27376
Aox3
Name: aldehyde oxidase 3
Synonyms: AOH1, 1200011D03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71724
Homologene: 90899
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240690
Homologene: 8792
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Zfp518a
Name: zinc finger protein 518A
Synonyms: 6330417C12Rik, 2810401C22Rik, Zfp518
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Tgs1
Name: trimethylguanosine synthase 1
Synonyms: Pimt, D4Ertd800e, Ncoa6ip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 116940
Homologene: 32608
Styk1
Name: serine/threonine/tyrosine kinase 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243659
Homologene: 49545
Or1d2
Name: olfactory receptor family 1 subfamily D member 2
Synonyms: GA_x6K02T2P1NL-4500587-4501525, MOR127-5P, Olfr412
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258153
Homologene: 37634
Slc25a21
Name: solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Synonyms: 9930033G19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217593
Homologene: 6988
Lpgat1
Name: lysophosphatidylglycerol acyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226856
Homologene: 8914
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Krt79
Name: keratin 79
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223917
Homologene: 89169
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77772
Homologene: 14981
Samd1
Name: sterile alpha motif domain containing 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 666704
Homologene: 124206
Esp15
Name: exocrine gland secreted peptide 15
Synonyms: Gm9041
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 668200
VEGA: 17
Tcap
Name: titin-cap
Synonyms: Telethonin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21393
Homologene: 2724
Krtap2-20
Name: keratin associated protein 2-20
Synonyms: Gm11562
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100502803
Homologene: 136079
Ccl21a
Name: C-C motif chemokine ligand 21 (serine)
Synonyms: ALP, Tca4, Exodus-2, SLC, 6Ckine, 6CKBAC2, Scya21, Scya21b, CKb9, Gm1987
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18829
Homologene: 2247
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 6,802,992 bp (GRCm38)
  • C to T, chromosome 1 at 58,176,489 bp (GRCm38)
  • T to A, chromosome 1 at 60,131,999 bp (GRCm38)
  • G to C, chromosome 1 at 66,777,991 bp (GRCm38)
  • G to A, chromosome 1 at 87,503,288 bp (GRCm38)
  • T to A, chromosome 1 at 191,778,475 bp (GRCm38)
  • T to G, chromosome 2 at 25,284,970 bp (GRCm38)
  • G to A, chromosome 3 at 83,924,051 bp (GRCm38)
  • A to T, chromosome 3 at 89,354,155 bp (GRCm38)
  • A to T, chromosome 3 at 90,210,352 bp (GRCm38)
  • C to A, chromosome 4 at 3,585,869 bp (GRCm38)
  • G to A, chromosome 4 at 42,773,875 bp (GRCm38)
  • T to A, chromosome 4 at 113,870,669 bp (GRCm38)
  • T to A, chromosome 5 at 101,930,094 bp (GRCm38)
  • A to T, chromosome 5 at 121,310,681 bp (GRCm38)
  • G to A, chromosome 6 at 125,307,385 bp (GRCm38)
  • CTCTTCATGATTTTCTT to CTCTT, chromosome 6 at 131,301,649 bp (GRCm38)
  • G to T, chromosome 7 at 82,595,381 bp (GRCm38)
  • T to C, chromosome 8 at 83,999,360 bp (GRCm38)
  • T to C, chromosome 9 at 8,901,917 bp (GRCm38)
  • T to A, chromosome 9 at 14,592,806 bp (GRCm38)
  • A to G, chromosome 9 at 16,003,861 bp (GRCm38)
  • T to C, chromosome 9 at 44,836,202 bp (GRCm38)
  • T to A, chromosome 9 at 107,901,579 bp (GRCm38)
  • A to G, chromosome 10 at 11,164,460 bp (GRCm38)
  • G to T, chromosome 11 at 50,603,506 bp (GRCm38)
  • G to A, chromosome 11 at 59,133,856 bp (GRCm38)
  • A to G, chromosome 11 at 74,365,032 bp (GRCm38)
  • A to G, chromosome 11 at 98,384,402 bp (GRCm38)
  • G to A, chromosome 11 at 99,620,030 bp (GRCm38)
  • T to C, chromosome 12 at 56,738,597 bp (GRCm38)
  • G to T, chromosome 12 at 70,198,529 bp (GRCm38)
  • T to G, chromosome 12 at 104,314,683 bp (GRCm38)
  • A to G, chromosome 14 at 49,080,299 bp (GRCm38)
  • A to T, chromosome 15 at 85,131,905 bp (GRCm38)
  • T to G, chromosome 15 at 101,930,761 bp (GRCm38)
  • A to T, chromosome 16 at 89,898,506 bp (GRCm38)
  • A to T, chromosome 17 at 17,087,636 bp (GRCm38)
  • A to G, chromosome 17 at 39,644,712 bp (GRCm38)
  • A to G, chromosome 18 at 10,594,510 bp (GRCm38)
  • T to C, chromosome 18 at 62,540,990 bp (GRCm38)
  • G to A, chromosome 19 at 22,926,131 bp (GRCm38)
  • T to A, chromosome 19 at 40,915,445 bp (GRCm38)
  • A to G, chromosome 19 at 59,301,252 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9750 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069996-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.