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Strain Name:
C57BL/6J-MtgxR9753Btlr/Mmmh
Stock Number:
069999-MU
Citation ID:
RRID:MMRRC_069999-MU
Other Names:
R9753 (G1)
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Gaps, Prgs
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Fbrsl1
Name: fibrosin-like 1
Synonyms: LOC381668, 2410025L10Rik, Gm29766
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: 5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 68,198,903 bp (GRCm38)
  • T to G, chromosome 1 at 132,018,143 bp (GRCm38)
  • T to C, chromosome 2 at 32,612,249 bp (GRCm38)
  • T to C, chromosome 2 at 69,867,521 bp (GRCm38)
  • T to C, chromosome 2 at 143,793,230 bp (GRCm38)
  • T to C, chromosome 3 at 37,319,531 bp (GRCm38)
  • C to T, chromosome 3 at 79,508,104 bp (GRCm38)
  • C to A, chromosome 3 at 88,108,869 bp (GRCm38)
  • C to T, chromosome 3 at 94,402,186 bp (GRCm38)
  • A to G, chromosome 3 at 107,968,177 bp (GRCm38)
  • C to T, chromosome 4 at 43,182,842 bp (GRCm38)
  • T to C, chromosome 4 at 43,568,716 bp (GRCm38)
  • T to C, chromosome 4 at 43,665,574 bp (GRCm38)
  • T to C, chromosome 4 at 155,293,202 bp (GRCm38)
  • A to T, chromosome 5 at 10,949,053 bp (GRCm38)
  • A to G, chromosome 5 at 110,378,969 bp (GRCm38)
  • T to C, chromosome 6 at 42,486,573 bp (GRCm38)
  • G to C, chromosome 6 at 116,022,110 bp (GRCm38)
  • G to A, chromosome 6 at 125,307,385 bp (GRCm38)
  • CTCTTCATGATTTTCTT to CTCTT, chromosome 6 at 131,301,649 bp (GRCm38)
  • A to C, chromosome 7 at 12,041,732 bp (GRCm38)
  • A to G, chromosome 8 at 104,853,617 bp (GRCm38)
  • A to G, chromosome 8 at 105,690,907 bp (GRCm38)
  • T to C, chromosome 8 at 110,490,766 bp (GRCm38)
  • T to C, chromosome 9 at 50,895,839 bp (GRCm38)
  • A to T, chromosome 9 at 51,238,336 bp (GRCm38)
  • G to A, chromosome 9 at 58,844,036 bp (GRCm38)
  • G to A, chromosome 10 at 41,383,500 bp (GRCm38)
  • T to C, chromosome 10 at 51,628,268 bp (GRCm38)
  • A to C, chromosome 10 at 79,612,233 bp (GRCm38)
  • A to G, chromosome 10 at 93,970,321 bp (GRCm38)
  • G to A, chromosome 11 at 4,039,982 bp (GRCm38)
  • A to G, chromosome 11 at 34,273,673 bp (GRCm38)
  • A to G, chromosome 11 at 99,388,966 bp (GRCm38)
  • A to G, chromosome 11 at 106,312,631 bp (GRCm38)
  • A to G, chromosome 12 at 21,276,889 bp (GRCm38)
  • T to A, chromosome 12 at 82,416,989 bp (GRCm38)
  • C to A, chromosome 13 at 25,253,580 bp (GRCm38)
  • A to T, chromosome 15 at 53,344,671 bp (GRCm38)
  • T to G, chromosome 15 at 101,930,761 bp (GRCm38)
  • C to T, chromosome 16 at 91,634,061 bp (GRCm38)
  • T to C, chromosome 16 at 96,023,828 bp (GRCm38)
  • A to C, chromosome 17 at 19,065,403 bp (GRCm38)
  • T to C, chromosome 17 at 24,972,346 bp (GRCm38)
  • C to A, chromosome 17 at 33,215,714 bp (GRCm38)
  • A to G, chromosome 17 at 71,799,073 bp (GRCm38)
  • T to A, chromosome 18 at 11,064,706 bp (GRCm38)
  • T to A, chromosome 19 at 12,108,692 bp (GRCm38)
  • C to T, chromosome 19 at 39,877,547 bp (GRCm38)
  • T to C, chromosome 19 at 47,034,634 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9753 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069999-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.