Strain Name:
C57BL/6J-MtgxR9753Btlr/Mmmh
Stock Number:
069999-MU
Citation ID:
RRID:MMRRC_069999-MU
Other Names:
R9753 (G1)
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: Spar, 4931426N11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Prgs, Gaps
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Fbrsl1
Name: fibrosin-like 1
Synonyms: 2410025L10Rik, Gm29766, LOC381668
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, 5330419I02Rik, D530019K20Rik, repro5, G1-403-16
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Ssb
Name: small RNA binding exonuclease protection factor La
Synonyms: autoantigen La, La protein, SS-B, Sjogren syndrome antigen B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20823
Homologene: 2366
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, 5830477H08Rik, Tce4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Krt10
Name: keratin 10
Synonyms: D130054E02Rik, cytokeratin 10, K1C1, Krt1-10, K10, keratin 10, suprabasal cytokeratin 10, Krt-1.10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16661
HGNC: HGNC:6413
Homologene: 137236
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Ltbr
Name: lymphotoxin B receptor
Synonyms: TNF receptor-related protein, TNF-R-III, Tnfrsf3, LT-beta receptor, Tnfbr, Ltar, TNFRrp, LT beta-R, TNFCR, LTbetaR, TNFR2-RP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy3, hyrh, hy-3, 1700034M11Rik, 4930545D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Synonyms: SPC2, prohormone convertase 2, 6330411F23Rik, Nec-2, Phpp-2, Nec2, PC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18549
HGNC: HGNC:8744
Homologene: 37640
Gstm3
Name: glutathione S-transferase, mu 3
Synonyms: Fsc2, mGSTM5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14864
HGNC: HGNC:4632
Homologene: 37356
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Ces2c
Name: carboxylesterase 2C
Synonyms: Ces2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234671
HGNC: HGNC:1864
Homologene: 138298
Ak9
Name: adenylate kinase 9
Synonyms: Akd2, LOC215946, Akd1, Gm7127
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 633979
Homologene: 67934
Or2r2
Name: olfactory receptor family 2 subfamily R member 2
Synonyms: MOR257-7P, GA_x6K02T2P3E9-5073878-5074816, Olfr456
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259144
Homologene: 79406
Sik2
Name: salt inducible kinase 2
Synonyms: Snf1lk2, G630080D20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235344
Homologene: 22875
Cd79b
Name: CD79B antigen
Synonyms: Igb, B29, Ig-beta, Igbeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15985
HGNC: HGNC:1699
Homologene: 521
Or10h5
Name: olfactory receptor family 10 subfamily H member 5
Synonyms: Gm4461, Olfr1564
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043474
Homologene: 133726
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: LERN4, Lrrn6d, A530050P17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320747
Homologene: 18563
St6galnac6
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Synonyms: ST6GalNAcVI, Siat7f
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50935
Homologene: 8390
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224552
Homologene: 115024
Styk1
Name: serine/threonine/tyrosine kinase 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243659
Homologene: 49545
Pcgf6
Name: polycomb group ring finger 6
Synonyms: Rnf134, MBLR, 4933407A11Rik, Mel18 and Bmi1-like RING finger protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71041
VEGA: 19
Homologene: 12378
Sec14l4
Name: SEC14-like lipid binding 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103655
Homologene: 68807
Bbs12
Name: Bardet-Biedl syndrome 12
Synonyms: LOC386537, LOC241950, LOC241950
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241950
Homologene: 17634
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Gba2
Name: glucosidase beta 2
Synonyms: bile acid
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230101
Homologene: 10859
Prkcz
Name: protein kinase C, zeta
Synonyms: zetaPKC, aPKCzeta, Pkcz
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18762
HGNC: HGNC:9412
Homologene: 55681
C2cd4c
Name: C2 calcium-dependent domain containing 4C
Synonyms: Fam148c, 4932409I22Rik, LOC237397
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237397
VEGA: 10
Homologene: 19012
Vmn1r77
Name: vomeronasal 1 receptor 77
Synonyms: Gm6935
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628946
Homologene: 103843
Itgb1bp1
Name: integrin beta 1 binding protein 1
Synonyms: bodenin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16413
Homologene: 3496
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330401
Homologene: 8995
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: Rsnl2, 4833417L20Rik, 1700074B05Rik, 1700024K14Rik, 5830409B12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Gata6
Name: GATA binding protein 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14465
VEGA: 18
HGNC: HGNC:4174
Homologene: 68449
Or4d6
Name: olfactory receptor family 4 subfamily D member 6
Synonyms: MOR239-5, Olfr1428, GA_x6K02T2RE5P-2468394-2467450
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258673
Homologene: 17339
Vezt
Name: vezatin, adherens junctions transmembrane protein
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215008
Homologene: 9739
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: D130029J02Rik, Rltpr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234695
Homologene: 128439
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Nrsn1
Name: neurensin 1
Synonyms: Neuro-p24, Neurensin-1, Vmp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22360
Homologene: 7597
Krt79
Name: keratin 79
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223917
Homologene: 89169
Fam221b
Name: family with sequence similarity 221, member B
Synonyms: 4930412F15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242408
Homologene: 52184
Elk4
Name: ELK4, member of ETS oncogene family
Synonyms: Sap1, A130026I01Rik, 2310011G17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13714
HGNC: HGNC:3326
Homologene: 1492
Pou2af1
Name: POU domain, class 2, associating factor 1
Synonyms: BOB.1, OCA-B, OBF-1, OBF.1, Bob-1, OCAB, Bob1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18985
VEGA: 9
HGNC: HGNC:9211
Homologene: 4543
Speer1k
Name: spermatogenesis associated glutamate (E)-rich protein 1K
Synonyms: Gm8857
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 667880
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 68,198,903 bp (GRCm38)
  • T to G, chromosome 1 at 132,018,143 bp (GRCm38)
  • T to C, chromosome 2 at 32,612,249 bp (GRCm38)
  • T to C, chromosome 2 at 69,867,521 bp (GRCm38)
  • T to C, chromosome 2 at 143,793,230 bp (GRCm38)
  • T to C, chromosome 3 at 37,319,531 bp (GRCm38)
  • C to T, chromosome 3 at 79,508,104 bp (GRCm38)
  • C to A, chromosome 3 at 88,108,869 bp (GRCm38)
  • C to T, chromosome 3 at 94,402,186 bp (GRCm38)
  • A to G, chromosome 3 at 107,968,177 bp (GRCm38)
  • C to T, chromosome 4 at 43,182,842 bp (GRCm38)
  • T to C, chromosome 4 at 43,568,716 bp (GRCm38)
  • T to C, chromosome 4 at 43,665,574 bp (GRCm38)
  • T to C, chromosome 4 at 155,293,202 bp (GRCm38)
  • A to T, chromosome 5 at 10,949,053 bp (GRCm38)
  • A to G, chromosome 5 at 110,378,969 bp (GRCm38)
  • T to C, chromosome 6 at 42,486,573 bp (GRCm38)
  • G to C, chromosome 6 at 116,022,110 bp (GRCm38)
  • G to A, chromosome 6 at 125,307,385 bp (GRCm38)
  • CTCTTCATGATTTTCTT to CTCTT, chromosome 6 at 131,301,649 bp (GRCm38)
  • A to C, chromosome 7 at 12,041,732 bp (GRCm38)
  • A to G, chromosome 8 at 104,853,617 bp (GRCm38)
  • A to G, chromosome 8 at 105,690,907 bp (GRCm38)
  • T to C, chromosome 8 at 110,490,766 bp (GRCm38)
  • T to C, chromosome 9 at 50,895,839 bp (GRCm38)
  • A to T, chromosome 9 at 51,238,336 bp (GRCm38)
  • G to A, chromosome 9 at 58,844,036 bp (GRCm38)
  • G to A, chromosome 10 at 41,383,500 bp (GRCm38)
  • T to C, chromosome 10 at 51,628,268 bp (GRCm38)
  • A to C, chromosome 10 at 79,612,233 bp (GRCm38)
  • A to G, chromosome 10 at 93,970,321 bp (GRCm38)
  • G to A, chromosome 11 at 4,039,982 bp (GRCm38)
  • A to G, chromosome 11 at 34,273,673 bp (GRCm38)
  • A to G, chromosome 11 at 99,388,966 bp (GRCm38)
  • A to G, chromosome 11 at 106,312,631 bp (GRCm38)
  • A to G, chromosome 12 at 21,276,889 bp (GRCm38)
  • T to A, chromosome 12 at 82,416,989 bp (GRCm38)
  • C to A, chromosome 13 at 25,253,580 bp (GRCm38)
  • A to T, chromosome 15 at 53,344,671 bp (GRCm38)
  • T to G, chromosome 15 at 101,930,761 bp (GRCm38)
  • C to T, chromosome 16 at 91,634,061 bp (GRCm38)
  • T to C, chromosome 16 at 96,023,828 bp (GRCm38)
  • A to C, chromosome 17 at 19,065,403 bp (GRCm38)
  • T to C, chromosome 17 at 24,972,346 bp (GRCm38)
  • C to A, chromosome 17 at 33,215,714 bp (GRCm38)
  • A to G, chromosome 17 at 71,799,073 bp (GRCm38)
  • T to A, chromosome 18 at 11,064,706 bp (GRCm38)
  • T to A, chromosome 19 at 12,108,692 bp (GRCm38)
  • C to T, chromosome 19 at 39,877,547 bp (GRCm38)
  • T to C, chromosome 19 at 47,034,634 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9753 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069999-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.