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Strain Name:
C57BL/6J-MtgxR9784Btlr/Mmmh
Stock Number:
070029-MU
Citation ID:
RRID:MMRRC_070029-MU
Other Names:
R9784 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Ptf1a
Name: pancreas specific transcription factor, 1a
Synonyms: PTF1-p48, bHLHa29
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19213
Homologene: 10304
Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: 1810048F20Rik, Fthfd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Katna1
Name: katanin p60 (ATPase-containing) subunit A1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23924
HGNC: HGNC:6216
Homologene: 56014
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, 2810449C13Rik, Usp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Stau1
Name: staufen double-stranded RNA binding protein 1
Synonyms: 5830401L18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20853
Homologene: 3384
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to A, chromosome 1 at 60,260,582 bp (GRCm38)
  • T to A, chromosome 2 at 5,930,811 bp (GRCm38)
  • G to T, chromosome 2 at 19,446,570 bp (GRCm38)
  • A to T, chromosome 2 at 24,761,789 bp (GRCm38)
  • C to T, chromosome 2 at 68,368,431 bp (GRCm38)
  • T to A, chromosome 2 at 83,860,443 bp (GRCm38)
  • A to G, chromosome 2 at 111,814,259 bp (GRCm38)
  • T to C, chromosome 2 at 166,949,775 bp (GRCm38)
  • T to C, chromosome 2 at 172,427,833 bp (GRCm38)
  • A to T, chromosome 2 at 180,683,561 bp (GRCm38)
  • T to C, chromosome 3 at 95,325,862 bp (GRCm38)
  • T to C, chromosome 3 at 103,337,507 bp (GRCm38)
  • T to C, chromosome 3 at 108,203,249 bp (GRCm38)
  • A to T, chromosome 3 at 151,509,311 bp (GRCm38)
  • G to T, chromosome 4 at 46,499,129 bp (GRCm38)
  • A to T, chromosome 4 at 121,041,029 bp (GRCm38)
  • T to A, chromosome 4 at 137,594,501 bp (GRCm38)
  • A to G, chromosome 4 at 154,286,965 bp (GRCm38)
  • T to C, chromosome 5 at 25,344,961 bp (GRCm38)
  • C to T, chromosome 5 at 38,039,291 bp (GRCm38)
  • G to T, chromosome 5 at 107,149,933 bp (GRCm38)
  • G to A, chromosome 5 at 113,190,661 bp (GRCm38)
  • A to G, chromosome 6 at 40,759,090 bp (GRCm38)
  • A to G, chromosome 6 at 90,564,442 bp (GRCm38)
  • A to T, chromosome 6 at 138,147,801 bp (GRCm38)
  • T to A, chromosome 7 at 17,037,151 bp (GRCm38)
  • G to A, chromosome 7 at 44,312,918 bp (GRCm38)
  • T to A, chromosome 7 at 103,552,059 bp (GRCm38)
  • T to A, chromosome 7 at 103,787,525 bp (GRCm38)
  • A to C, chromosome 7 at 128,676,791 bp (GRCm38)
  • T to A, chromosome 7 at 141,694,542 bp (GRCm38)
  • T to A, chromosome 7 at 143,492,941 bp (GRCm38)
  • A to G, chromosome 8 at 3,876,337 bp (GRCm38)
  • A to C, chromosome 8 at 84,697,701 bp (GRCm38)
  • C to A, chromosome 8 at 88,591,702 bp (GRCm38)
  • A to T, chromosome 9 at 19,375,820 bp (GRCm38)
  • A to T, chromosome 9 at 36,758,783 bp (GRCm38)
  • A to G, chromosome 9 at 50,604,973 bp (GRCm38)
  • T to A, chromosome 9 at 57,680,279 bp (GRCm38)
  • T to A, chromosome 9 at 58,982,220 bp (GRCm38)
  • C to T, chromosome 9 at 95,717,593 bp (GRCm38)
  • T to A, chromosome 9 at 107,527,147 bp (GRCm38)
  • G to C, chromosome 10 at 7,762,826 bp (GRCm38)
  • A to G, chromosome 10 at 19,935,066 bp (GRCm38)
  • A to T, chromosome 10 at 74,631,380 bp (GRCm38)
  • A to G, chromosome 10 at 80,156,413 bp (GRCm38)
  • T to C, chromosome 10 at 80,648,647 bp (GRCm38)
  • T to A, chromosome 10 at 83,506,750 bp (GRCm38)
  • A to T, chromosome 11 at 29,825,253 bp (GRCm38)
  • A to G, chromosome 11 at 60,467,722 bp (GRCm38)
  • T to A, chromosome 11 at 66,085,134 bp (GRCm38)
  • T to C, chromosome 11 at 69,232,690 bp (GRCm38)
  • T to C, chromosome 11 at 70,252,839 bp (GRCm38)
  • G to T, chromosome 11 at 74,317,883 bp (GRCm38)
  • C to T, chromosome 11 at 82,764,979 bp (GRCm38)
  • T to A, chromosome 11 at 82,926,160 bp (GRCm38)
  • A to G, chromosome 11 at 99,518,362 bp (GRCm38)
  • C to T, chromosome 11 at 100,207,140 bp (GRCm38)
  • C to T, chromosome 11 at 100,498,286 bp (GRCm38)
  • C to T, chromosome 11 at 100,576,611 bp (GRCm38)
  • T to C, chromosome 11 at 108,570,391 bp (GRCm38)
  • A to G, chromosome 12 at 28,747,458 bp (GRCm38)
  • A to T, chromosome 12 at 53,141,070 bp (GRCm38)
  • T to A, chromosome 12 at 64,967,394 bp (GRCm38)
  • T to A, chromosome 12 at 77,412,839 bp (GRCm38)
  • T to C, chromosome 12 at 111,843,685 bp (GRCm38)
  • T to A, chromosome 12 at 115,067,608 bp (GRCm38)
  • C to T, chromosome 12 at 115,468,374 bp (GRCm38)
  • A to G, chromosome 13 at 21,495,598 bp (GRCm38)
  • C to T, chromosome 13 at 41,049,360 bp (GRCm38)
  • T to C, chromosome 14 at 80,011,908 bp (GRCm38)
  • T to C, chromosome 15 at 31,453,503 bp (GRCm38)
  • C to A, chromosome 16 at 29,618,211 bp (GRCm38)
  • G to A, chromosome 16 at 97,748,106 bp (GRCm38)
  • T to A, chromosome 17 at 7,351,308 bp (GRCm38)
  • T to A, chromosome 17 at 33,242,175 bp (GRCm38)
  • C to T, chromosome 18 at 22,517,254 bp (GRCm38)
  • T to G, chromosome 18 at 43,986,423 bp (GRCm38)
  • T to G, chromosome 18 at 63,904,165 bp (GRCm38)
  • T to C, chromosome 19 at 12,651,480 bp (GRCm38)
  • G to A, chromosome 19 at 12,884,510 bp (GRCm38)
  • T to A, chromosome 19 at 13,165,449 bp (GRCm38)
  • A to G, chromosome 19 at 40,000,499 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9784 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
070029-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.