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Strain Name:
C57BL/6J-MtgxR9794Btlr/Mmmh
Stock Number:
070039-MU
Citation ID:
RRID:MMRRC_070039-MU
Other Names:
R9794 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
Ngf
Name: nerve growth factor
Synonyms: Ngfb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18049
HGNC: HGNC:7808
Homologene: 1876
Psen2
Name: presenilin 2
Synonyms: ALG-3, PS-2, PS2, Ad4h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19165
HGNC: HGNC:9509
Homologene: 386
Rab6b
Name: RAB6B, member RAS oncogene family
Synonyms: C330006L04Rik, D9Bwg0185e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270192
Homologene: 39749
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 139,478,742 bp (GRCm38)
  • C to T, chromosome 1 at 169,507,385 bp (GRCm38)
  • A to T, chromosome 1 at 180,240,729 bp (GRCm38)
  • C to A, chromosome 2 at 25,469,117 bp (GRCm38)
  • A to G, chromosome 2 at 76,875,849 bp (GRCm38)
  • A to G, chromosome 2 at 85,992,120 bp (GRCm38)
  • C to A, chromosome 3 at 40,805,100 bp (GRCm38)
  • G to A, chromosome 3 at 102,520,816 bp (GRCm38)
  • A to T, chromosome 3 at 129,800,424 bp (GRCm38)
  • T to A, chromosome 4 at 12,095,335 bp (GRCm38)
  • T to G, chromosome 4 at 14,590,416 bp (GRCm38)
  • A to G, chromosome 4 at 124,793,381 bp (GRCm38)
  • G to T, chromosome 4 at 136,938,724 bp (GRCm38)
  • T to C, chromosome 5 at 29,224,127 bp (GRCm38)
  • C to A, chromosome 5 at 110,318,335 bp (GRCm38)
  • T to C, chromosome 5 at 112,973,582 bp (GRCm38)
  • T to C, chromosome 5 at 114,249,517 bp (GRCm38)
  • G to T, chromosome 5 at 134,722,498 bp (GRCm38)
  • T to A, chromosome 5 at 140,462,315 bp (GRCm38)
  • A to G, chromosome 6 at 23,000,205 bp (GRCm38)
  • T to C, chromosome 6 at 30,625,921 bp (GRCm38)
  • T to A, chromosome 6 at 57,737,723 bp (GRCm38)
  • A to T, chromosome 6 at 113,476,765 bp (GRCm38)
  • C to T, chromosome 6 at 136,818,023 bp (GRCm38)
  • A to G, chromosome 6 at 136,929,610 bp (GRCm38)
  • T to A, chromosome 6 at 146,832,535 bp (GRCm38)
  • T to A, chromosome 6 at 149,326,741 bp (GRCm38)
  • A to G, chromosome 7 at 12,844,594 bp (GRCm38)
  • A to G, chromosome 7 at 26,564,877 bp (GRCm38)
  • A to T, chromosome 7 at 26,681,696 bp (GRCm38)
  • G to A, chromosome 7 at 101,244,203 bp (GRCm38)
  • G to A, chromosome 7 at 140,294,803 bp (GRCm38)
  • G to A, chromosome 7 at 140,345,570 bp (GRCm38)
  • G to A, chromosome 8 at 3,451,634 bp (GRCm38)
  • A to G, chromosome 8 at 36,236,081 bp (GRCm38)
  • A to G, chromosome 8 at 45,381,412 bp (GRCm38)
  • G to A, chromosome 8 at 104,741,264 bp (GRCm38)
  • C to T, chromosome 9 at 53,518,567 bp (GRCm38)
  • T to C, chromosome 9 at 56,621,308 bp (GRCm38)
  • A to T, chromosome 9 at 57,602,239 bp (GRCm38)
  • A to G, chromosome 9 at 62,755,586 bp (GRCm38)
  • A to T, chromosome 9 at 71,579,800 bp (GRCm38)
  • T to A, chromosome 9 at 80,092,308 bp (GRCm38)
  • T to C, chromosome 9 at 103,163,862 bp (GRCm38)
  • T to C, chromosome 9 at 108,851,303 bp (GRCm38)
  • C to A, chromosome 10 at 14,438,452 bp (GRCm38)
  • T to C, chromosome 10 at 80,834,873 bp (GRCm38)
  • T to C, chromosome 11 at 50,171,178 bp (GRCm38)
  • A to T, chromosome 11 at 51,598,385 bp (GRCm38)
  • G to A, chromosome 11 at 69,557,406 bp (GRCm38)
  • G to T, chromosome 12 at 8,268,430 bp (GRCm38)
  • T to A, chromosome 12 at 73,697,970 bp (GRCm38)
  • C to A, chromosome 12 at 76,000,843 bp (GRCm38)
  • T to A, chromosome 12 at 84,173,802 bp (GRCm38)
  • T to C, chromosome 13 at 22,827,262 bp (GRCm38)
  • G to T, chromosome 13 at 32,715,967 bp (GRCm38)
  • A to C, chromosome 13 at 49,076,198 bp (GRCm38)
  • A to T, chromosome 13 at 53,358,767 bp (GRCm38)
  • A to G, chromosome 13 at 60,761,268 bp (GRCm38)
  • A to T, chromosome 13 at 103,834,851 bp (GRCm38)
  • T to A, chromosome 14 at 70,157,589 bp (GRCm38)
  • C to T, chromosome 14 at 84,532,910 bp (GRCm38)
  • C to A, chromosome 15 at 100,697,978 bp (GRCm38)
  • T to A, chromosome 15 at 101,035,451 bp (GRCm38)
  • A to T, chromosome 16 at 21,956,112 bp (GRCm38)
  • A to G, chromosome 16 at 46,153,979 bp (GRCm38)
  • T to C, chromosome 17 at 45,666,326 bp (GRCm38)
  • A to T, chromosome 18 at 20,540,097 bp (GRCm38)
  • A to G, chromosome 18 at 25,203,974 bp (GRCm38)
  • T to C, chromosome 18 at 60,963,959 bp (GRCm38)
  • T to C, chromosome 19 at 6,517,034 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9794 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
070039-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.