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Strain Name:
C57BL/6J-MtgxR9798Btlr/Mmmh
Stock Number:
070043-MU
Citation ID:
RRID:MMRRC_070043-MU
Other Names:
R9798 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, neuroaxonal dystrophy, 5830426A08Rik, ROSA62, nmf261, 1700022P15Rik, Spnb4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Pias3
Name: protein inhibitor of activated STAT 3
Synonyms: Pias3L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229615
Homologene: 4447
Il23a
Name: interleukin 23, alpha subunit p19
Synonyms: p19, IL-23, IL-23p19
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83430
VEGA: 10
Homologene: 12832
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Flt-2, Fgfr-1, Hspy, Eask, FGFR-I, Fr1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 91,323,564 bp (GRCm38)
  • A to G, chromosome 1 at 188,911,805 bp (GRCm38)
  • T to A, chromosome 2 at 82,979,881 bp (GRCm38)
  • T to C, chromosome 2 at 86,085,262 bp (GRCm38)
  • A to T, chromosome 3 at 36,598,290 bp (GRCm38)
  • T to A, chromosome 3 at 59,331,705 bp (GRCm38)
  • T to C, chromosome 3 at 96,699,565 bp (GRCm38)
  • C to T, chromosome 3 at 103,744,115 bp (GRCm38)
  • T to C, chromosome 3 at 103,997,553 bp (GRCm38)
  • C to T, chromosome 3 at 129,811,772 bp (GRCm38)
  • C to T, chromosome 4 at 53,747,128 bp (GRCm38)
  • A to G, chromosome 4 at 62,463,414 bp (GRCm38)
  • A to G, chromosome 4 at 86,156,690 bp (GRCm38)
  • A to G, chromosome 5 at 21,795,808 bp (GRCm38)
  • A to T, chromosome 5 at 25,984,186 bp (GRCm38)
  • T to C, chromosome 5 at 73,035,059 bp (GRCm38)
  • A to G, chromosome 5 at 138,261,678 bp (GRCm38)
  • T to C, chromosome 6 at 7,689,395 bp (GRCm38)
  • C to A, chromosome 6 at 141,655,353 bp (GRCm38)
  • C to A, chromosome 7 at 23,894,308 bp (GRCm38)
  • T to C, chromosome 7 at 27,357,292 bp (GRCm38)
  • T to A, chromosome 7 at 81,092,652 bp (GRCm38)
  • C to T, chromosome 8 at 25,563,507 bp (GRCm38)
  • T to A, chromosome 8 at 33,572,693 bp (GRCm38)
  • T to C, chromosome 8 at 105,616,166 bp (GRCm38)
  • T to A, chromosome 9 at 19,375,281 bp (GRCm38)
  • T to A, chromosome 9 at 67,919,364 bp (GRCm38)
  • G to T, chromosome 9 at 75,529,519 bp (GRCm38)
  • G to C, chromosome 9 at 75,529,521 bp (GRCm38)
  • A to C, chromosome 9 at 75,529,523 bp (GRCm38)
  • A to T, chromosome 9 at 108,828,595 bp (GRCm38)
  • G to A, chromosome 10 at 78,793,333 bp (GRCm38)
  • G to C, chromosome 10 at 128,296,960 bp (GRCm38)
  • T to G, chromosome 11 at 69,879,906 bp (GRCm38)
  • A to T, chromosome 13 at 60,853,120 bp (GRCm38)
  • A to G, chromosome 14 at 14,782,056 bp (GRCm38)
  • T to C, chromosome 14 at 16,389,845 bp (GRCm38)
  • T to C, chromosome 16 at 50,224,758 bp (GRCm38)
  • G to A, chromosome 16 at 90,248,645 bp (GRCm38)
  • C to A, chromosome 16 at 96,372,875 bp (GRCm38)
  • T to C, chromosome 17 at 25,753,797 bp (GRCm38)
  • T to C, chromosome 17 at 88,637,044 bp (GRCm38)
  • A to T, chromosome 18 at 60,603,760 bp (GRCm38)
  • A to G, chromosome 19 at 9,013,619 bp (GRCm38)
  • G to A, chromosome 19 at 40,727,345 bp (GRCm38)
  • G to A, chromosome 19 at 40,794,636 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9798 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
070043-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.