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Availability & Fees Order this Strain
CRISPR/Cas9 gene editing was used to place Lox p sites in sequences flanking exon 8 (introns 8 and 9, away from sequences implicated in splicing). Diagnostic BamH1 and Ecor1 restriction sites were also inserted into intron 8. When crossed with cre recombinase-expressing mice, exon 9 is deleted in cre-expressing tissues resulting in the inability to express the beta and gamma isoforms of SH2B1. Only the alpha and delta isoforms of SH2B1 are able to be expressed.
Argetsinger LS, Flores A, Svezhova N, Ellis M, Reynolds C, Cote JL, Cline JM, Myers MG, Carter-Su C. Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance. Endocrinology. 2023 Mar 13;164(5):bqad032. doi: 10.1210/endocr/bqad032. (Medline PMID: 36799031)
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.
A Commercial License Agreement from the Donor is required for for-profit entities to use this strain. For more information, please contact John Corthell.
A Commercial License Agreement from the Donor is required for for-profit entities to use this strain. For more information, please contact John Corthell
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.