Strain Name:
C3;B6-Nle1l11Jus1/Mmucd
Stock Number:
000077-UCD
Citation ID:
RRID:MMRRC_000077-UCD
Other Names:
Lethal 1, l11Jus1, C3;B6-l11Jus1/Mmcd

Strain Information

Nle1l11Jus1
Name: notchless homolog 1; lethal, Chr 11, Justice 1
Synonyms: l11Jus01
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
Nle1
Name: notchless homolog 1
Synonyms: notchless, Nle, l11Jus4, l11Jus1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217011
Homologene: 5494
Genetic Alterations
Offspring of an ENU-induced male.
Phenotype
Failure to implant, lethal prior to 9.5dpc
Mammalian Phenotype Terms
Allelic Composition: Nle1l11Jus1/Nle1l11Jus1 (Genetic Background: Not Specified )

MeSH Terms
  • Animals
  • Cardiovascular System/embryology
  • Cardiovascular System/metabolism
  • Chromosomes, Mammalian/genetics
  • Conserved Sequence/genetics
  • Ethylnitrosourea/pharmacology
  • Female
  • Gastrula/metabolism
  • Genes, Lethal/genetics
  • Hematopoiesis/genetics
  • Humans
  • Infertility/genetics
  • Male
  • Mice/embryology
  • Mice/genetics
  • Mutagenesis/drug effects
  • Mutagenesis/genetics
  • Mutagens/pharmacology
  • Mutation/genetics
Strain Development
Suggested Control Mice
  • Wildtype littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Birth Defects
Donor
Monica J. Justice, Ph.D., Baylor College of Medicine
Primary Reference
Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ. Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6. (Medline PMID: 12955145)

Colony and Husbandry Information

In order to determine the genotype of MMRRC:000077, a Lethal strain, it must be used in conjunction with MMRRC:009973. MMRRC:009973 is a combination of MMRRC:000055 and The Jackson Laboratory strain 000268; this combination results in a curly coated, yellow ear and yellow tail mouse which is a reporter for chromosome 11 mutations in the Lethal strains.

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu .
Coat Color
Agouti
MMRRC Breeding System
The MMRRC has always maintained this strain in a cryopreserved format. Information in the "Breeding" and "Reproductive statistics" sections has been provided by the Donating Investigator
Breeding Scheme(s)
Generation
Not applicable
Overall Breeding Performance
Good
Average litter size
5
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
000077-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
000077-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity3
000077-UCD-RESUS Litter recovered from cryo-archive $3,033.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.