Strain Name:
STOCK Krt25Re In(11Trp53;11Wnt3)8Brd/Mmucd
Stock Number:
009973-UCD
Citation ID:
RRID:MMRRC_009973-UCD
Other Names:
Chr11-1/Re, STOCK Krt25Re In(11Trp53;11Wnt3)8Brd/Mmcd

Strain Information

In(11Trp53;11Wnt3)8Brd
Name: inversion, Chr 11, Allan Bradley 8
Type:
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Inversion
Wnt3tm2Brd
Name: wingless-type MMTV integration site family, member 3; targeted mutation 2, Allan Bradley
Synonyms: Wnt3In(11Trp53;11Wnt3)8Brd, Wnt3Brdm2
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Inversion
Trp53tm2Brd
Name: transformation related protein 53; targeted mutation 2, Allan Bradley
Synonyms: Tyrp53Brdm2, Trp53tyr, Trp53In(11Trp53;11Wnt3)8Brd
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Inversion
Krt25Re
Name: keratin 25; rex
Synonyms: Re
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Spontaneous Mutation
Krt25
Name: keratin 25
Synonyms: 4631426H08Rik, mIRSa1
Type: Gene
Species: Mouse
Chromosome: 11
Alteration at locus: Spontaneous Mutation
NCBI: 70810
Homologene: 77127
Genetic Alterations
Spontaneous mutation/Inversion mutation
Genotype Determination
  • Genotype by Phenotype. See below.
Phenotype
Heterozygotes: This 24 cM inversion is used as a "balancer" for chromosome 11 mutations in mutagenesis screens. The inversion disrupts Wnt3 and is lethal in the homozygous state. The normal copy of Chr 11 carries the the curly coat mutation, rex. Mice heterozygous for both mutations are yellow with a curly coat. When combined with ENU mutagenized C57BL/6 males, progeny can be identified by phenotype (see mating scheme).

Homozygotes: lethal

Mammalian Phenotype Terms
Allelic Composition: Wnt3In(11Trp53;11Wnt3)8Brd/Wnt3In(11Trp53;11Wnt3)8Brd (Genetic Background: 129S7/SvEvBrd )

Allelic Composition: Trp53In(11Trp53;11Wnt3)8Brd/Trp53In(11Trp53;11Wnt3)8Brd (Genetic Background: 129S7/SvEvBrd )

Allelic Composition: Trp53In(11Trp53;11Wnt3)8Brd/Trp53In(11Trp53;11Wnt3)8Brd (Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 )

Allelic Composition: Krt25Re/Krt25Re (Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J )

Allelic Composition: Krt25Re/Krt25Re (Genetic Background: Not Specified )

Allelic Composition: Krt25Re/Krt25+ (Genetic Background: Not Specified )

MeSH Terms
  • Animals
  • Cardiovascular System/embryology
  • Cardiovascular System/metabolism
  • Chromosomes, Mammalian/genetics
  • Conserved Sequence/genetics
  • Ethylnitrosourea/pharmacology
  • Female
  • Gastrula/metabolism
  • Genes, Lethal/genetics
  • Hematopoiesis/genetics
  • Humans
  • Infertility/genetics
  • Male
  • Mice/embryology
  • Mice/genetics
  • Mutagenesis/drug effects
  • Mutagenesis/genetics
  • Mutagens/pharmacology
  • Mutation/genetics
Suggested Control Mice
  • Wildtype littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
Donor
Monica J. Justice, Ph.D., Baylor College of Medicine
Primary Reference
Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ. Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6. (Medline PMID: 12955145)

Colony and Husbandry Information

These mice are reporter mice to be used with strains containing mutations of chromosome 11 as noted in the reference text.

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.
Coat Color
Agouti plus curly coat and yellow hair on ears and tail
MMRRC Breeding System
Sib mating
Breeding Scheme(s)
  • Hetero/Hetero female (curly+yellow) x Hetero/Hetero male (curly+ yellow)
  • View Mating Scheme
Generation
Unknown
Overall Breeding Performance
Fair to Poor
Average litter size
4
Recommended wean age
3 -4 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
009973-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
009973-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity3
009973-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.