Strain Name:
FVB/N-Tg(LPA,LPAL2,PLG)1Hgc/Mmmh
Stock Number:
000424-MU
Citation ID:
RRID:MMRRC_000424-MU

Strain Information

LPA
Name: lipoprotein, Lp(a)
Type: Gene
Species: Homo sapiens (human)
Chromosome: 6
Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18815
VEGA: 17
HGNC: HGNC:9071
Homologene: 55452
LPAL2
Name: lipoprotein, Lp(a)-like 2, pseudogene
Type: Gene
Species: Homo sapiens (human)
Chromosome: 6
Tg(LPA,LPAL2,PLG)1Hgc
Name: transgene insertion 1, Human Genome Center
Synonyms: Tg(LPA LPAL-2 PLG)1Hgc, apo(a) YAC
Type: Transgene
Species: Mus musculus (mouse)
Chromosome: unknown
Alteration at locus: Transgenic
Genetic Alterations
Transgenic mice were created using a 270 kb YAC that harbors human apo(a) and apo(a) like and plasminogen genes.
Genotype Determination
Phenotype
YAC apo(a) mice have very high plasma levels of apo(a), upto 75 mg per deciliter.
MeSH Terms
  • Acute-Phase Reaction/genetics
  • Animals
  • Apolipoproteins/genetics
  • Apoprotein(a)
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Artificial, Yeast
  • DNA Primers/genetics
  • Female
  • Gene Expression Regulation/drug effects
  • Gonadal Steroid Hormones/pharmacology
  • Humans
  • Lipoprotein(a)
  • Male
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Tissue Distribution
Suggested Control Mice
  • Wildtype littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
  • Cardiovascular
  • Models for Human Disease
  • Research Tools
Donor
Edward M. Rubin, M.D., Ph.D., Lawrence Berkeley National Laboratory
Primary Reference
Frazer KA, Narla G, Zhang JL, Rubin EM. The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice. Nat Genet. 1995 Apr;9(4):424-31. (Medline PMID: 7795650)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu

Order Request Information

Limited quantities of breeder mice (up to 2 males and 2 females or 4 mice) per investigator per month are available from a live colony, usually available to ship in under 12 weeks. Larger quantities may be available, please contact the distributing center directly at mmrrc@missouri.edu for more details.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

A Commercial License Agreement from the Donor is required for for-profit entities to use this strain. For more information, please contact Virginia de la Puente.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

A Commercial License Agreement from the Donor is required for for-profit entities to use this strain. For more information, please contact Virginia de la Puente

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
000424-MU-HET-F
000424-MU-HET-M
000424-MU-WT-F
000424-MU-WT-M
Heterozygous / Hemizygous Female
Heterozygous / Hemizygous Male
Wild Type Female
Wild Type Male
$290.00 / $590.00
Non-Profit / For-Profit
Per Mouse The mmrrc@missouri.edu may assess additional fees for any special requests (e.g., specific age or weight of mice, etc.).
000424-MU-SPERM Cryo-preserved spermatozoa $437.00 / $817.00
Non-Profit / For-Profit
Aliquot Approximate quantity3
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.