Strain Detail Sheet

Strain Name:
B6.129-Sgcdtm189Kcam/Mmmh
Stock Number:
016838-MU
Citation ID:
RRID:MMRRC_016838-MU
Other Names:
d-sarcoglycan

Strain Information

Gene Details

Sgcdtm189Kcam
Name: sarcoglycan, delta (dystrophin-associated glycoprotein) / (unnamed provisional allele)
Type: Allele
Species: Mus musculus (mouse)
Sgcd
Name: sarcoglycan, delta (dystrophin-associated glycoprotein)
Synonyms: delta-SG
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24052
Homologene: 285
Genome Browser [Click image to go to Jbrowse]



Additional Resources
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Genetic Alterations
A targeting vector containing a neo cassette was inserted to replace exon 2, which encodes for 63 amino acids of the intracelular domain and the entire transmembrane region.
Genotype Determination
ES Cell Line
R1 derived from (129X1/SvJ x 129S1/Sv)F1-Kitl+

Strain Description

Phenotype
Homozygous: Sgcd null mice show a phenotype consistent with human limb girdle muscular dystrophy. Pathology includes large regions of necrosis in nearly all skeletal muscles. Severe necrotic lesions are present in diaphragm of mice under 1 month of age. Mice older than 6 months of age display cardiomyopathy. Mice display irregularities of the coronary vasculature.

Heterozygous: Heterozygotes do not show any known morphological abnormalities.
MeSH Terms
  • Animals
  • Cardiomyopathy, Dilated/genetics
  • Cardiomyopathy, Dilated/metabolism
  • Cardiomyopathy, Dilated/pathology
  • Carrier Proteins/physiology
  • Coronary Vessels/pathology
  • Cytoskeletal Proteins/deficiency
  • Cytoskeletal Proteins/genetics
  • Cytoskeletal Proteins/physiology
  • Macromolecular Substances
  • Membrane Glycoproteins/deficiency
  • Membrane Glycoproteins/genetics
  • Membrane Glycoproteins/physiology
  • Membrane Proteins/physiology
  • Mice
  • Mice, Knockout
  • Muscle, Smooth, Vascular/metabolism
  • Muscle, Smooth, Vascular/pathology
  • Muscular Dystrophy, Animal/genetics
  • Muscular Dystrophy, Animal/metabolism
  • Muscular Dystrophy, Animal/pathology
  • Myocardium/pathology
  • Necrosis
  • Neoplasm Proteins
  • Physical Conditioning, Animal/adverse effects
  • Sarcoglycans
  • Age Factors
  • Cardiomyopathies/blood
  • Cardiomyopathies/genetics
  • Cardiomyopathies/prevention & control
  • Carrier Proteins/genetics
  • Coronary Circulation
  • Disease Models, Animal
  • Membrane Proteins/deficiency
  • Membrane Proteins/genetics
  • Myocardium/metabolism
  • Troponin/blood
  • Vasodilator Agents/therapeutic use
  • Verapamil/therapeutic use
Suggested Control Mice
Wild-type littermates or C57BL/6 mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Research Applications

  • Cardiovascular
  • Developmental Biology
  • Models for Human Disease
  • Musculoskeletal

Strain Origin

Donor
Kevin P. Campbell, Ph.D., University of Iowa, Carver College of Medicine
Primary Reference
  • Coral-Vazquez R, Cohn RD, Moore SA, Hill JA, Weiss RM, Davisson RL, Straub V, Barresi R, Bansal D, Hrstka RF, Williamson R, Campbell KP. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell. 1999 Aug 20;98(4):465-74. (Medline PMID: 10481911)
  • Cohn RD, Durbeej M, Moore SA, Coral-Vazquez R, Prouty S, Campbell KP. Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex. J Clin Invest. 2001 Jan;107(2):R1-7. (Medline PMID: 11160141)

Colony and Husbandry Information

Special Considerations

Mice with decreased mobility may benefit from gruel as food/water source.

Health Status Report

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Sib-mating
Generation
N5
Overall Breeding Performance
Good

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: 6 8
Average litter size
6
Recommended wean age
3 weeks

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

- Products for this strain are Not Yet Available for Ordering
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To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.