Strain Name:
C57BL/6J-MtgxR0014Btlr/Mmmh
Stock Number:
038309-MU
Citation ID:
RRID:MMRRC_038309-MU
Other Names:
R0014 (G1), C57BL/6J-MtgxR0014Btlr
Major Collection:

Gene Information

Pitx2
Name: paired-like homeodomain transcription factor 2
Synonyms: Otlx2, Munc30, Pitx2a, Pitx2b, Pitx2c, solurshin, Brx1, Brx1a, Brx1b, Ptx2, Rieg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18741
HGNC: HGNC:9005
Homologene: 55454
Cd2ap
Name: CD2-associated protein
Synonyms: Mets1, METS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12488
VEGA: 17
Homologene: 7663
Nek6
Name: NIMA (never in mitosis gene a)-related expressed kinase 6
Synonyms: 1300007C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59126
HGNC: HGNC:7749
Homologene: 49379
Exog
Name: endo/exonuclease (5'-3'), endonuclease G-like
Synonyms: Endogl1, ENGL-B, ENDOGL2, ENGL-a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208194
VEGA: 9
HGNC: HGNC:3347
Homologene: 3745
Rcbtb1
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
Synonyms: 5430409I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71330
Homologene: 10061
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Epc2
Name: enhancer of polycomb homolog 2
Synonyms: D2Ertd694e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227867
Homologene: 32274
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Als2cr6, 9430073A21Rik, Alsin, 3222402C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Dmbx1
Name: diencephalon/mesencephalon homeobox 1
Synonyms: Atx, Cdmx, Mbx, Dmbx1, Otx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140477
Homologene: 15639
F2rl2
Name: coagulation factor II (thrombin) receptor-like 2
Synonyms: PAR-3, PAR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14064
HGNC: HGNC:3539
Homologene: 36151
Clcc1
Name: chloride channel CLIC-like 1
Synonyms: Mclc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229725
Homologene: 9032
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: 5430414H02Rik, ZWS1, peroxisome biogenesis factor 1, E330005K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, TSP-1, tbsp1, Thbs-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21825
Homologene: 31142
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, D630001M17Rik, 4921513O20Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Klhl28
Name: kelch-like 28
Synonyms: 4122402F11Rik, Btbd5, 2810440N09Rik, 4931401E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66689
VEGA: 12
Homologene: 23036
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: ESTM41, Pik4cb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Tut1
Name: terminal uridylyl transferase 1, U6 snRNA-specific
Synonyms: TUTase6, Tent1, PAPD2, 2700038E08Rik, Rbm21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 70044
VEGA: 19
Homologene: 69361
Capg
Name: capping protein (actin filament), gelsolin-like
Synonyms: gCap39, mbh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12332
HGNC: HGNC:1474
Homologene: 37523
Rorc
Name: RAR-related orphan receptor gamma
Synonyms: thymus orphan receptor, Thor, RORgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19885
Homologene: 21051
Rexo2
Name: RNA exonuclease 2
Synonyms: Sfn, Rex2, Smfn, 1810038D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104444
VEGA: 9
Homologene: 6447
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Cat2, Atrc2, Tea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11988
Homologene: 20659
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Wdr63
Name: WD repeat domain 63
Synonyms: IC140, Ida7, 4931433A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242253
Homologene: 44922
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: Jr6, 9430031J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241134
Homologene: 18239
Ccdc125
Name: coiled-coil domain containing 125
Synonyms: 5830436D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76041
VEGA: 13
Homologene: 27932
A1bg
Name: alpha-1-B glycoprotein
Synonyms: C44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 117586
VEGA: 15
HGNC: HGNC:5
Homologene: 11167
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: ASC2, AIB3, ASC-2, RAP250, NRC, PRIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56406
Homologene: 137337
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, melastatin, LTRPC1, 4732499L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Cfap126
Name: cilia and flagella associated protein 126
Synonyms: Fltp, Flattop, 1700009P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75472
Homologene: 23682
9130409I23Rik
Name: RIKEN cDNA 9130409I23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 619326
Homologene: 134522
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Olfr1301
Name: olfactory receptor 1301
Synonyms: MOR248-5, GA_x6K02T2Q125-72805651-72806589
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258889
Homologene: 74057
Tbc1d20
Name: TBC1 domain family, member 20
Synonyms: 2810442O16Rik, bs, 1110028I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67231
Homologene: 32574
Gucy1b1
Name: guanylate cyclase 1, soluble, beta 1
Synonyms: Gucy1b3, beta 1 sGC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54195
HGNC: HGNC:4687
Homologene: 664
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: DPD, E330028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Gbp5
Name: guanylate binding protein 5
Synonyms: 5330409J06Rik, Gbp5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229898
Homologene: 14183
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: Cngbeta2, CCNC2, CNG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329977
Homologene: 77947
C3ar1
Name: complement component 3a receptor 1
Synonyms: anaphylatoxin C3a receptor, C3aR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12267
HGNC: HGNC:1319
Homologene: 2992
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232875
Homologene: 122136
Olfr520
Name: olfactory receptor 520
Synonyms: MOR101-1, GA_x6K02T2PBJ9-2411789-2412739
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259066
Homologene: 17484
Olfr543
Name: olfactory receptor 543
Synonyms: GA_x6K02T2PBJ9-5199377-5198367, MOR42-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257947
Homologene: 81631
Cdt1
Name: chromatin licensing and DNA replication factor 1
Synonyms: Ris2, 2610318F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67177
Homologene: 32650
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Ccr5
Name: chemokine (C-C motif) receptor 5
Synonyms: CD195, Cmkbr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12774
HGNC: HGNC:1606
Homologene: 37325
Fbxo30
Name: F-box protein 30
Synonyms: 1700026A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71865
Homologene: 12959
Syde1
Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms: mSYD1A, 1200008N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71709
VEGA: 10
Homologene: 13195
Ankrd52
Name: ankyrin repeat domain 52
Synonyms: G431002C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237615
Homologene: 18227
P2rx5
Name: purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms: P2X5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94045
HGNC: HGNC:8536
Homologene: 1924
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Ptpdc1
Name: protein tyrosine phosphatase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218232
VEGA: 13
Homologene: 17576
Zfp458
Name: zinc finger protein 458
Synonyms: Rslcan-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238690
VEGA: 13
Homologene: 128170
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Khdrbs3
Name: KH domain containing, RNA binding, signal transduction associated 3
Synonyms: Etle, SLM-2, T-STAR, Salp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13992
VEGA: 15
Homologene: 4780
Hmox2
Name: heme oxygenase 2
Synonyms: HO2, HO-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15369
HGNC: HGNC:5014
Homologene: 1611
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: 2900055E17Rik, E430001K23Rik, Dagk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Fyttd1
Name: forty-two-three domain containing 1
Synonyms: 3830421F13Rik, 3830411L18Rik, 2010005M05Rik, 4933423A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69823
Homologene: 12334
Psma8
Name: proteasome subunit alpha 8
Synonyms: 2410072D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 73677
VEGA: 18
Homologene: 2086
Polr2g
Name: polymerase (RNA) II (DNA directed) polypeptide G
Synonyms: RBP7, Rpo2-7l, 2410046K11Rik, A230108L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67710
VEGA: 19
HGNC: HGNC:9194
Homologene: 2019
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 59,211,388 bp
  • T to C, chromosome 1 at 81,241,951 bp
  • A to G, chromosome 1 at 87,881,881 bp
  • A to G, chromosome 1 at 171,125,784 bp
  • T to C, chromosome 1 at 181,055,131 bp
  • T to C, chromosome 2 at 38,558,844 bp
  • A to T, chromosome 2 at 49,522,525 bp
  • G to A, chromosome 2 at 52,287,156 bp
  • A to G, chromosome 2 at 111,754,774 bp
  • A to G, chromosome 2 at 118,113,350 bp
  • A to T, chromosome 2 at 152,311,781 bp
  • A to C, chromosome 2 at 155,438,043 bp
  • A to G, chromosome 2 at 181,240,511 bp
  • T to C, chromosome 3 at 82,039,861 bp
  • T to A, chromosome 3 at 94,377,613 bp
  • T to G, chromosome 3 at 94,998,897 bp
  • T to A, chromosome 3 at 108,661,396 bp
  • T to C, chromosome 3 at 119,141,935 bp
  • T to G, chromosome 3 at 129,218,499 bp
  • T to A, chromosome 3 at 142,506,735 bp
  • T to C, chromosome 3 at 146,081,423 bp
  • T to C, chromosome 4 at 19,396,685 bp
  • G to T, chromosome 4 at 115,918,024 bp
  • A to T, chromosome 4 at 141,928,408 bp
  • G to A, chromosome 5 at 3,626,141 bp
  • C to T, chromosome 5 at 14,680,451 bp
  • A to G, chromosome 6 at 72,561,043 bp
  • C to T, chromosome 6 at 122,850,851 bp
  • A to T, chromosome 7 at 12,769,417 bp
  • A to G, chromosome 7 at 64,248,222 bp
  • T to C, chromosome 7 at 99,736,049 bp
  • A to G, chromosome 7 at 102,477,477 bp
  • T to C, chromosome 8 at 40,911,028 bp
  • C to T, chromosome 8 at 122,572,566 bp
  • A to T, chromosome 9 at 48,474,447 bp
  • T to A, chromosome 9 at 57,139,701 bp
  • T to C, chromosome 9 at 119,452,278 bp
  • T to C, chromosome 9 at 124,124,621 bp
  • T to A, chromosome 10 at 11,289,859 bp
  • T to C, chromosome 10 at 78,590,034 bp
  • C to A, chromosome 10 at 128,386,452 bp
  • T to A, chromosome 11 at 73,167,062 bp
  • T to C, chromosome 12 at 11,241,641 bp
  • C to T, chromosome 12 at 21,336,644 bp
  • T to C, chromosome 12 at 64,957,302 bp
  • G to T, chromosome 13 at 48,586,919 bp
  • A to G, chromosome 13 at 67,258,090 bp
  • A to T, chromosome 13 at 95,700,909 bp
  • A to C, chromosome 13 at 100,684,338 bp
  • A to G, chromosome 14 at 33,107,173 bp
  • G to T, chromosome 14 at 59,235,242 bp
  • T to A, chromosome 15 at 60,919,732 bp
  • A to G, chromosome 15 at 69,024,835 bp
  • T to C, chromosome 15 at 91,802,045 bp
  • T to A, chromosome 16 at 4,765,033 bp
  • A to T, chromosome 16 at 22,565,364 bp
  • G to A, chromosome 16 at 32,905,554 bp
  • T to C, chromosome 17 at 42,807,928 bp
  • A to G, chromosome 18 at 14,726,530 bp
  • A to G, chromosome 18 at 63,904,101 bp
  • A to G, chromosome 19 at 8,793,652 bp
  • T to A, chromosome 19 at 8,962,447 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0014 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038309-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.