Strain Name:
C57BL/6J-MtgxR0030Btlr/Mmmh
Stock Number:
038324-MU
Citation ID:
RRID:MMRRC_038324-MU
Other Names:
R0030 (G1), C57BL/6J-MtgxR0030Btlr
Major Collection:

Gene Information

Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, MyHC-I, Myhc-b, Myhcb, B-MHC, beta-MHC, betaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Ppp4c
Name: protein phosphatase 4, catalytic subunit
Synonyms: 1110002D08Rik, PPX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56420
HGNC: HGNC:9319
Homologene: 2038
Agap1
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms: Centg2, Ggap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 347722
Homologene: 56689
Aebp2
Name: AE binding protein 2
Synonyms: B230313N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11569
Homologene: 40690
Cabin1
Name: calcineurin binding protein 1
Synonyms: Cain, Ppp3in, A330070M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 104248
VEGA: 10
Homologene: 49307
Fry
Name: FRY microtubule binding protein
Synonyms: 9330186A19Rik, cg003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320365
Homologene: 113770
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226747
Homologene: 9142
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, D530019K20Rik, 5330419I02Rik, G1-403-16, repro5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 93871
Homologene: 23130
Kif18a
Name: kinesin family member 18A
Synonyms: gcd2, B130001M12Rik, N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228421
Homologene: 41820
Cct4
Name: chaperonin containing Tcp1, subunit 4 (delta)
Synonyms: A45, 2610204B21Rik, Cctd, T complex protein 1, delta, TCP-1 delta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12464
HGNC: HGNC:1617
Homologene: 4695
Scp2
Name: sterol carrier protein 2, liver
Synonyms: nonspecific lipid transfer protein, ns-LTP, SCP-2, SCPx, NSL-TP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20280
Homologene: 37717
Eps15l1
Name: epidermal growth factor receptor pathway substrate 15-like 1
Synonyms: 9830147J04Rik, Eps15R, Eps15-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13859
Homologene: 31881
Polg
Name: polymerase (DNA directed), gamma
Synonyms: polymerase gamma, Pol gamma, Polga, mitochondrial DNA polymerase gamma, mitochondrial DNA polymerase-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18975
HGNC: HGNC:9179
Homologene: 2016
Foxi2
Name: forkhead box I2
Synonyms: B130055A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 270004
Homologene: 18838
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20264
VEGA: 9
Homologene: 21300
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: p600, A930005E13Rik, 1810009A16Rik, LOC381562, D930005K06Rik, Zubr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69116
Homologene: 10804
Nmbr
Name: neuromedin B receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18101
HGNC: HGNC:7843
Homologene: 20560
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Ifnk
Name: interferon kappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 387510
Homologene: 36384
Tbk1
Name: TANK-binding kinase 1
Synonyms: 1200008B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56480
VEGA: 10
Homologene: 22742
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269700
Homologene: 28297
Pax1
Name: paired box 1
Synonyms: Pax-1, hbs, wavy tail, wt, hunchback
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329650
Homologene: 43143
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b1154Clo, Mdnah5, Dnahc5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Vnn1
Name: vanin 1
Synonyms: V-1, pantetheinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22361
Homologene: 32130
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: sj, DHPR alpha1s, muscle dysgenesis, fmd, Cchl1a3, mdg, Cav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Lcn10
Name: lipocalin 10
Synonyms: 9230112J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 332578
Homologene: 52253
Ggt7
Name: gamma-glutamyltransferase 7
Synonyms: 6330563L03Rik, 1110017C11Rik, Ggtl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 207182
HGNC: HGNC:4259
Homologene: 70866
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320664
Homologene: 75128
Ttc39a
Name: tetratricopeptide repeat domain 39A
Synonyms: 4922503N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230603
Homologene: 17739
Pqlc2
Name: PQ loop repeat containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 212555
Homologene: 56784
Mmp23
Name: matrix metallopeptidase 23
Synonyms: cysteine array matrix metalloproteinase, CA-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 26561
HGNC: HGNC:7171
Homologene: 3424
Ankrd65
Name: ankyrin repeat domain 65
Synonyms: E230028L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242805
Homologene: 28427
Gm7298
Name: predicted gene 7298
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 640530
HGNC: null
Homologene: null
Faap24
Name: Fanconi anemia core complex associated protein 24
Synonyms: C230052I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101831
Homologene: 17535
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: TAT1, Mct10, 2610103N14Rik, PRO0813
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72472
VEGA: 10
Homologene: 75089
Olfr1395
Name: olfactory receptor 1395
Synonyms: GA_x6K02T2QP88-6286247-6285294, MOR277-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258877
HGNC: null
Homologene: 105890
Odf4
Name: outer dense fiber of sperm tails 4
Synonyms: Oppo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 252868
Homologene: 17099
Ikzf3
Name: IKAROS family zinc finger 3
Synonyms: 5830411O07Rik, Aiolos, Zfpn1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22780
Homologene: 8269
Crip1
Name: cysteine-rich protein 1 (intestinal)
Synonyms: Crip, CRP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 12925
HGNC: HGNC:2360
Homologene: 37465
Mrps30
Name: mitochondrial ribosomal protein S30
Synonyms: 2610020A16Rik, Pdcd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 59054
HGNC: HGNC:8769
Homologene: 9607
Cyp4f40
Name: cytochrome P450, family 4, subfamily f, polypeptide 40
Synonyms: EG631304
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 631304
VEGA: 17
Homologene: 117991
Dxo
Name: decapping exoribonuclease
Synonyms: Dom3z
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 112403
HGNC: HGNC:2992
Homologene: 38061
Ptchd4
Name: patched domain containing 4
Synonyms: 3110082D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627626
VEGA: 17
Homologene: 78322
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 210510
Homologene: 19364
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 89,888,744 bp
  • C to T, chromosome 1 at 110,138,068 bp
  • T to C, chromosome 1 at 136,094,989 bp
  • G to A, chromosome 1 at 179,752,436 bp
  • C to T, chromosome 1 at 188,822,657 bp
  • T to C, chromosome 2 at 25,685,081 bp
  • A to T, chromosome 2 at 109,333,318 bp
  • A to T, chromosome 2 at 140,660,317 bp
  • C to A, chromosome 2 at 147,368,582 bp
  • G to T, chromosome 2 at 155,506,488 bp
  • G to T, chromosome 2 at 172,427,842 bp
  • T to G, chromosome 3 at 59,248,655 bp
  • T to G, chromosome 4 at 35,152,489 bp
  • T to A, chromosome 4 at 108,107,690 bp
  • C to A, chromosome 4 at 109,422,973 bp
  • A to G, chromosome 4 at 139,306,453 bp
  • G to T, chromosome 4 at 139,426,793 bp
  • G to A, chromosome 4 at 155,651,311 bp
  • A to C, chromosome 4 at 155,791,485 bp
  • C to T, chromosome 5 at 108,613,547 bp
  • G to T, chromosome 5 at 121,262,588 bp
  • T to A, chromosome 5 at 150,372,569 bp
  • T to A, chromosome 6 at 121,774,050 bp
  • A to C, chromosome 6 at 140,637,747 bp
  • A to T, chromosome 7 at 35,392,860 bp
  • A to T, chromosome 7 at 79,452,128 bp
  • A to G, chromosome 7 at 126,788,433 bp
  • A to G, chromosome 7 at 135,411,616 bp
  • C to A, chromosome 8 at 23,093,893 bp
  • A to G, chromosome 8 at 72,373,050 bp
  • A to G, chromosome 9 at 106,912,313 bp
  • G to C, chromosome 9 at 119,669,990 bp
  • AATA to AATATATA, chromosome 10 at 14,760,718 bp
  • A to G, chromosome 10 at 23,900,846 bp
  • A to G, chromosome 10 at 40,076,823 bp
  • A to G, chromosome 10 at 75,751,619 bp
  • A to G, chromosome 10 at 121,561,624 bp
  • T to C, chromosome 11 at 23,001,357 bp
  • T to A, chromosome 11 at 49,149,040 bp
  • T to A, chromosome 11 at 68,926,941 bp
  • T to C, chromosome 11 at 98,467,612 bp
  • G to A, chromosome 12 at 113,153,376 bp
  • T to C, chromosome 13 at 118,382,995 bp
  • T to A, chromosome 14 at 54,991,970 bp
  • A to T, chromosome 15 at 28,451,517 bp
  • A to G, chromosome 16 at 96,021,256 bp
  • T to C, chromosome 17 at 32,675,973 bp
  • A to G, chromosome 17 at 34,837,938 bp
  • T to A, chromosome 17 at 42,317,108 bp
  • T to C, chromosome 17 at 43,626,591 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0030 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038324-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.