Strain Name:
C57BL/6J-MtgxR0035Btlr/Mmmh
Stock Number:
038329-MU
Citation ID:
RRID:MMRRC_038329-MU
Other Names:
R0035 (G1), C57BL/6J-MtgxR0035Btlr
Major Collection:

Strain Information

Acvr1c
Name: activin A receptor, type IC
Synonyms: Alk-7, ALK7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269275
Homologene: 26724
Nos2
Name: nitric oxide synthase 2, inducible
Synonyms: Nos-2, iNOS, NOS-II, Nos2a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18126
HGNC: HGNC:7873
Homologene: 55473
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: D230038D11Rik, 1810033J14Rik, Mll5, 9530077A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap-5, Mtap5, LC1, Mtap1b, MAP5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Armh3
Name: armadillo-like helical domain containing 3
Synonyms: 9130011E15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71617
VEGA: 19
Homologene: 15843
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: AIP5, SDRP1, 8030445B08Rik, Tiul1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Par-1, Emk
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70227
Homologene: 133818
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: 4932438A13Rik, Tweek, FSA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Rad50l, Mrell
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Xpo5
Name: exportin 5
Synonyms: 2410004H11Rik, Exp5, 2700038C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72322
VEGA: 17
Homologene: 69316
Htr1f
Name: 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms: Htr1eb
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15557
VEGA: 16
HGNC: HGNC:5292
Homologene: 37361
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: Nob1, Nobq1, 1110062G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57915
Homologene: 56856
Golph3
Name: golgi phosphoprotein 3
Synonyms: 4733401N08Rik, 5730410D03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66629
VEGA: 15
Homologene: 56942
Zfp982
Name: zinc finger protein 982
Synonyms: Gm13152
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195531
Hspd1
Name: heat shock protein 1 (chaperonin)
Synonyms: Hsp60
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15510
HGNC: HGNC:5261
Homologene: 1626
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Abcb6
Name: ATP-binding cassette, sub-family B member 6
Synonyms: 1200005B17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74104
HGNC: HGNC:47
Homologene: 11375
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: alpha3(IV), tumstatin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Clic5
Name: chloride intracellular channel 5
Synonyms: 5730531E12Rik, nmf318
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224796
VEGA: 17
Homologene: 987
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242505
Homologene: 28424
Ush2a
Name: usherin
Synonyms: Ushrn, A930037M10Rik, MUSH2A, LOC269160, A930011D15Rik, LOC381317, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Cfap53
Name: cilia and flagella associated protein 53
Synonyms: 4933415I03Rik, Ccdc11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74453
Homologene: 27056
Clspn
Name: claspin
Synonyms: C85083, E130314M08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269582
Homologene: 11138
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 333669
Homologene: 129891
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209590
Homologene: 16930
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320664
Homologene: 75128
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Il36b
Name: interleukin 36B
Synonyms: Il1f8, If36b, 2310043N20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69677
Homologene: 18278
Obp2b
Name: odorant binding protein 2B
Synonyms: Lcn14, OTTMUSG00000012631
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 383678
Homologene: 135821
Abo
Name: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
Synonyms: cis-AB transferase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80908
HGNC: HGNC:79
Homologene: 69306
Tspyl3
Name: TSPY-like 3
Synonyms: LOC241732
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241732
Homologene: 19093
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381463
Homologene: 131277
Ap4b1
Name: adaptor-related protein complex AP-4, beta 1
Synonyms: AP-4 beta-4, 1810038H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67489
HGNC: HGNC:572
Homologene: 38203
Akna
Name: AT-hook transcription factor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100182
Homologene: 49947
Ptafr
Name: platelet-activating factor receptor
Synonyms: PAF receptor, PAFR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19204
HGNC: HGNC:9582
Homologene: 20260
Aadacl4
Name: arylacetamide deacetylase like 4
Synonyms: Gm13177
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435815
Homologene: 82530
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22307
Homologene: 129606
Clec4a3
Name: C-type lectin domain family 4, member a3
Synonyms: 3110037K17Rik, mDcir3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73149
Homologene: 9413
Klrb1-ps1
Name: killer cell lectin-like receptor subfamily B member 1, pseudogene 1
Synonyms: Nkrp1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 724020
Tbc1d17
Name: TBC1 domain family, member 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233204
Homologene: 11656
3110040N11Rik
Name: RIKEN cDNA 3110040N11 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67290
Homologene: 12109
Or14a259
Name: olfactory receptor family 14 subfamily A member 259
Synonyms: MOR219-2, GA_x6K02T2NHDJ-9744055-9745014, Olfr305
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258609
Homologene: 128128
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Me3
Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms: 1700020C08Rik, B230207H15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109264
HGNC: HGNC:6985
Homologene: 100773
Map6
Name: microtubule-associated protein 6
Synonyms: Mtap6, F-STOP, 2810411E12Rik, STOP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Defa21
Name: defensin, alpha, 21
Synonyms: 2010016B13Rik, Defcr21
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66298
Homologene: 113382
Deup1
Name: deuterosome assembly protein 1
Synonyms: Ccdc67, 4933401K09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234964
Homologene: 18760
Zc3h12c
Name: zinc finger CCCH type containing 12C
Synonyms: C230027N18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244871
VEGA: 9
Homologene: 35462
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: LOC235639, C030048J01Rik, Lba1, A230061D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Osbp2
Name: oxysterol binding protein 2
Synonyms: ORP-4, C630001G20Rik, OSBPL1, 1700095P05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74309
HGNC: HGNC:8504
Homologene: 75303
Chmp6
Name: charged multivesicular body protein 6
Synonyms: chromatin modifying protein 6, 2400004G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208092
Homologene: 11607
Il25
Name: interleukin 25
Synonyms: Il17e, IL-17E
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140806
VEGA: 14
Homologene: 15429
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Cntn1
Name: contactin 1
Synonyms: CNTN, usl, F3cam
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12805
HGNC: HGNC:2171
Homologene: 7274
Or5k1
Name: olfactory receptor family 5 subfamily K member 1
Synonyms: MOR184-3, GA_x54KRFPKG5P-54960233-54959268, Olfr173
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259002
Homologene: 45084
Dnase1l2
Name: deoxyribonuclease 1-like 2
Synonyms: 4733401H14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66705
HGNC: HGNC:2958
Homologene: 74391
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 37,165,689 bp
  • A to G, chromosome 1 at 51,778,382 bp
  • A to G, chromosome 1 at 55,083,783 bp
  • T to C, chromosome 1 at 58,354,422 bp
  • A to G, chromosome 1 at 75,175,007 bp
  • G to A, chromosome 1 at 82,672,753 bp
  • G to A, chromosome 1 at 188,356,888 bp
  • A to T, chromosome 2 at 24,159,878 bp
  • T to C, chromosome 2 at 25,738,633 bp
  • C to A, chromosome 2 at 26,843,373 bp
  • T to C, chromosome 2 at 31,990,367 bp
  • A to G, chromosome 2 at 58,315,779 bp
  • A to G, chromosome 2 at 153,224,320 bp
  • C to T, chromosome 2 at 172,416,492 bp
  • T to A, chromosome 3 at 36,987,598 bp
  • T to A, chromosome 3 at 102,949,573 bp
  • T to C, chromosome 3 at 103,820,664 bp
  • A to C, chromosome 4 at 19,631,116 bp
  • T to A, chromosome 4 at 63,382,445 bp
  • G to T, chromosome 4 at 73,762,854 bp
  • T to A, chromosome 4 at 106,368,027 bp
  • G to T, chromosome 4 at 126,565,003 bp
  • C to A, chromosome 4 at 132,579,553 bp
  • A to G, chromosome 4 at 144,617,941 bp
  • A to C, chromosome 4 at 147,512,692 bp
  • T to A, chromosome 5 at 23,485,621 bp
  • T to A, chromosome 5 at 64,256,737 bp
  • T to C, chromosome 5 at 108,997,601 bp
  • A to G, chromosome 6 at 67,473,788 bp
  • T to A, chromosome 6 at 122,967,549 bp
  • C to T, chromosome 6 at 129,129,343 bp
  • G to A, chromosome 7 at 39,537,282 bp
  • T to C, chromosome 7 at 44,841,408 bp
  • T to C, chromosome 7 at 81,788,549 bp
  • T to C, chromosome 7 at 86,364,187 bp
  • A to G, chromosome 7 at 86,920,205 bp
  • C to A, chromosome 7 at 89,851,759 bp
  • C to T, chromosome 7 at 99,317,608 bp
  • G to T, chromosome 7 at 104,769,062 bp
  • T to A, chromosome 8 at 21,025,768 bp
  • T to C, chromosome 9 at 15,599,821 bp
  • A to T, chromosome 9 at 52,143,747 bp
  • A to G, chromosome 9 at 53,513,180 bp
  • A to T, chromosome 9 at 111,366,776 bp
  • T to A, chromosome 10 at 28,263,508 bp
  • T to A, chromosome 10 at 39,072,738 bp
  • T to A, chromosome 10 at 75,993,864 bp
  • C to T, chromosome 11 at 3,717,997 bp
  • A to G, chromosome 11 at 53,655,027 bp
  • T to C, chromosome 11 at 78,945,727 bp
  • T to C, chromosome 11 at 119,916,682 bp
  • A to G, chromosome 13 at 99,435,338 bp
  • A to G, chromosome 14 at 47,730,379 bp
  • A to G, chromosome 14 at 54,933,096 bp
  • A to T, chromosome 14 at 110,749,932 bp
  • A to T, chromosome 15 at 12,339,690 bp
  • A to T, chromosome 15 at 64,699,368 bp
  • T to A, chromosome 15 at 92,232,088 bp
  • A to T, chromosome 16 at 58,797,122 bp
  • A to C, chromosome 16 at 64,926,497 bp
  • A to G, chromosome 17 at 24,441,075 bp
  • A to T, chromosome 17 at 30,683,621 bp
  • A to G, chromosome 17 at 44,275,313 bp
  • A to G, chromosome 17 at 46,240,175 bp
  • A to G, chromosome 18 at 74,300,207 bp
  • A to T, chromosome 19 at 7,284,652 bp
  • A to T, chromosome 19 at 45,891,240 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0035 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038329-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.