Strain Name:
C57BL/6J-MtgxR0041Btlr/Mmmh
Stock Number:
038335-MU
Citation ID:
RRID:MMRRC_038335-MU
Other Names:
R0041 (G1), C57BL/6J-MtgxR0041Btlr
Major Collection:

Strain Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NEFH, NF-H, NF200
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Vcan
Name: versican
Synonyms: DPEAAE, 5430420N07Rik, Cspg2, hdf, heart defect, PG-M
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: PEPCK, Pck-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: MommeD8, 9230110M18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
Swap70
Name: SWA-70 protein
Synonyms: 70kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20947
Homologene: 7557
Braf
Name: Braf transforming gene
Synonyms: Braf-2, Braf2, 9930012E13Rik, D6Ertd631e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109880
HGNC: HGNC:1097
Homologene: 3197
Rpl7a
Name: ribosomal protein L7A
Synonyms: surfeit 3, Surf-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27176
Homologene: 105462
Dtna
Name: dystrobrevin alpha
Synonyms: 2210407P21Rik, adbn, Dtn, 87K protein, a-DB-1, A0, alpha-dystrobrevin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
Synonyms: Rock-I, 1110055K06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19877
VEGA: 18
Homologene: 55899
Galnt4
Name: polypeptide N-acetylgalactosaminyltransferase 4
Synonyms: ppGaNTase-T4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14426
Homologene: 74511
Gigyf2
Name: GRB10 interacting GYF protein 2
Synonyms: 2610016F01Rik, Tnrc15, A830080H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227331
Homologene: 41048
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: 1110030C19Rik, TRPM4B, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213783
Homologene: 18897
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: Gpr125, Tem5-like, 3830613O22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Olfml1
Name: olfactomedin-like 1
Synonyms: mONT2, ONT2, MVAL564
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244198
Homologene: 45688
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: D12Ertd364e, C730036B14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Dlk1
Name: delta like non-canonical Notch ligand 1
Synonyms: ZOG, DlkI, pref-1, SCP1, pG2, Peg9, FA1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13386
HGNC: HGNC:2907
Homologene: 2846
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: C230094B15Rik, Corl1, Lbxcor1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207667
Homologene: 18175
Kcnk2
Name: potassium channel, subfamily K, member 2
Synonyms: TREK-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16526
HGNC: HGNC:6277
Homologene: 7794
Adamts13
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, L-type Cav1.2, Cchl1a1, Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Krt71
Name: keratin 71
Synonyms: mK6irs, mK6irs1, Ca, Cal4, Krt2-6g, Cu
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56735
Homologene: 88864
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Dcdc3, mG145, oxygen-regulated protein 1, Orp1, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
AI182371
Name: expressed sequence AI182371
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98870
Homologene: 87268
Zfp1001
Name: zinc finger protein 1001
Synonyms: Gm10130
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102633750
VEGA: 2
Syt11
Name: synaptotagmin XI
Synonyms: 6530420C11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229521
Homologene: 23120
Msto1
Name: misato 1, mitochondrial distribution and morphology regulator
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229524
Homologene: 41228
Ugt8a
Name: UDP galactosyltransferase 8A
Synonyms: Ugt8, mCerGT, Cgt
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22239
Homologene: 20715
Bspry
Name: B-box and SPRY domain containing
Synonyms: zetin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192120
Homologene: 9781
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Phkg1
Name: phosphorylase kinase gamma 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18682
HGNC: HGNC:8930
Homologene: 68508
Prss59
Name: serine protease 59
Synonyms: Tryx5, 1700074P13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73481
Homologene: 49905
Or6d13
Name: olfactory receptor family 6 subfamily D member 13
Synonyms: GA_x54KRFPKN04-58174409-58175392, MOR119-3, Olfr213
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258020
Homologene: 74186
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1, Oatp1a1, Slc21a1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28248
Homologene: 137261
Peg12
Name: paternally expressed 12
Synonyms: Frat3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27412
HGNC: HGNC:3944
Ac127374.1
Name: Uncharacterized protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Or8g34
Name: olfactory receptor family 8 subfamily G member 34
Synonyms: MOR171-53, Olfr954, MOR171-42, GA_x6K02T2PVTD-33158015-33158950
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258328
VEGA: 9
HGNC: HGNC:8484
Homologene: 71961
Treh
Name: trehalase (brush-border membrane glycoprotein)
Synonyms: 2210412M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58866
Homologene: 5198
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Ltf
Name: lactotransferrin
Synonyms: lactoferrin, Lf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17002
HGNC: HGNC:6720
Homologene: 1754
Mbd6
Name: methyl-CpG binding domain protein 6
Synonyms: D10Wsu93e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110962
Homologene: 14171
Rnf112
Name: ring finger protein 112
Synonyms: neurolastin, Zfp179, bfp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22671
Homologene: 5176
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: Myhs-f2, IId/x, IId, A530084A17Rik, MyHC-IId/x, Myhsf2, myosin heavy chain 2X, MYHC-IIX, Myhs-f
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 442801
Homologene: 18345
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: Gm11390, SPI3D
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Cdhr2
Name: cadherin-related family member 2
Synonyms: LOC268663, Pcdh24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268663
Homologene: 134510
Synb
Name: syncytin b
Synonyms: syncytin-B, D930020E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239167
Homologene: 86779
Wdr53
Name: WD repeat domain 53
Synonyms: 1500002B03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68980
Homologene: 15591
Efna5
Name: ephrin A5
Synonyms: Ephrin-A5, RAGS, Epl7, EFL-5, LERK-7, AL-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13640
HGNC: HGNC:3225
Homologene: 1482
Dynap
Name: dynactin associated protein
Synonyms: 2310002L13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75577
VEGA: 18
Homologene: 82463
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: Erk3-related, p63Mapk, A330097D03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
Avpi1
Name: arginine vasopressin-induced 1
Synonyms: 2310008N12Rik, mVIT32
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69534
Homologene: 11027
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,344,628 bp
  • A to G, chromosome 1 at 60,281,871 bp
  • A to C, chromosome 1 at 87,378,976 bp
  • G to A, chromosome 1 at 175,726,471 bp
  • G to T, chromosome 1 at 189,295,691 bp
  • A to G, chromosome 2 at 26,911,551 bp
  • A to G, chromosome 2 at 26,983,974 bp
  • T to A, chromosome 2 at 35,085,721 bp
  • A to G, chromosome 2 at 150,323,825 bp
  • A to G, chromosome 2 at 173,155,210 bp
  • A to G, chromosome 3 at 88,747,903 bp
  • A to G, chromosome 3 at 88,910,235 bp
  • T to C, chromosome 3 at 125,915,090 bp
  • G to A, chromosome 3 at 158,164,260 bp
  • G to C, chromosome 4 at 62,486,554 bp
  • A to G, chromosome 4 at 117,273,284 bp
  • T to A, chromosome 4 at 121,149,929 bp
  • A to G, chromosome 5 at 49,960,559 bp
  • T to A, chromosome 5 at 89,684,467 bp
  • T to A, chromosome 5 at 129,874,262 bp
  • C to T, chromosome 6 at 39,640,479 bp
  • A to T, chromosome 6 at 40,926,108 bp
  • G to A, chromosome 6 at 116,541,334 bp
  • T to A, chromosome 6 at 118,594,027 bp
  • A to G, chromosome 6 at 141,918,459 bp
  • A to G, chromosome 7 at 45,304,946 bp
  • T to A, chromosome 7 at 62,463,560 bp
  • A to T, chromosome 7 at 107,590,186 bp
  • A to G, chromosome 7 at 110,279,355 bp
  • A to T, chromosome 8 at 31,738,663 bp
  • T to A, chromosome 9 at 39,461,476 bp
  • T to C, chromosome 9 at 44,683,613 bp
  • T to G, chromosome 9 at 63,145,851 bp
  • T to A, chromosome 9 at 109,448,164 bp
  • T to A, chromosome 9 at 111,029,568 bp
  • T to A, chromosome 10 at 3,964,074 bp
  • T to A, chromosome 10 at 3,964,076 bp
  • A to G, chromosome 10 at 99,108,512 bp
  • A to G, chromosome 10 at 127,286,872 bp
  • C to T, chromosome 11 at 4,945,184 bp
  • G to T, chromosome 11 at 59,043,977 bp
  • T to A, chromosome 11 at 61,452,355 bp
  • A to C, chromosome 11 at 67,209,078 bp
  • A to T, chromosome 11 at 68,954,516 bp
  • A to G, chromosome 11 at 119,402,575 bp
  • T to A, chromosome 12 at 65,106,443 bp
  • G to C, chromosome 12 at 109,455,513 bp
  • A to G, chromosome 13 at 33,667,632 bp
  • A to T, chromosome 13 at 54,726,838 bp
  • T to A, chromosome 13 at 89,661,985 bp
  • T to C, chromosome 14 at 69,510,477 bp
  • C to A, chromosome 15 at 101,739,318 bp
  • T to C, chromosome 16 at 32,256,655 bp
  • A to T, chromosome 16 at 91,659,333 bp
  • C to A, chromosome 17 at 57,876,469 bp
  • A to T, chromosome 17 at 62,607,472 bp
  • T to C, chromosome 18 at 10,140,240 bp
  • C to T, chromosome 18 at 23,646,875 bp
  • A to G, chromosome 18 at 70,242,034 bp
  • A to T, chromosome 18 at 73,935,038 bp
  • C to A, chromosome 19 at 42,123,784 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0041 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038335-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.