Strain Name:
C57BL/6J-MtgxR0069Btlr/Mmmh
Stock Number:
038360-MU
Citation ID:
RRID:MMRRC_038360-MU
Other Names:
R0069 (G1), C57BL/6J-MtgxR0069Btlr
Major Collection:

Strain Information

Ebf2
Name: early B cell factor 2
Synonyms: Mmot1, D14Ggc1e, O/E-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13592
Homologene: 56471
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: ANT-1, 2610031L17Rik, 1190003A07Rik, U5-102K
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68879
Homologene: 5368
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Srisnf2l, G630026H09Rik, Arip4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Creb1
Name: cAMP responsive element binding protein 1
Synonyms: 2310001E10Rik, 3526402H21Rik, Creb-1, Creb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12912
HGNC: HGNC:2345
Homologene: 3223
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap1b, Mtap5, LC1, MAP5, Mtap-5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Xpnpep3
Name: X-prolyl aminopeptidase 3, mitochondrial
Synonyms: E430012M05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 321003
Nacc1
Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Synonyms: Btbd14b, 4930511N13Rik, Nac1, 2010001H03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66830
VEGA: 8
Homologene: 12042
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229543
Homologene: 11309
Fam168a
Name: family with sequence similarity 168, member A
Synonyms: 2610030B18Rik, B930006L02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319604
Homologene: 18702
Nfx1
Name: nuclear transcription factor, X-box binding 1
Synonyms: Tex42, 1300017N15Rik, TEG-42, 3000003M19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74164
HGNC: HGNC:7803
Homologene: 1875
Pole2
Name: polymerase (DNA directed), epsilon 2 (p59 subunit)
Synonyms: DNA polymerase epsilon small subunit
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18974
VEGA: 12
HGNC: HGNC:9178
Homologene: 2015
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Slc38a10
Name: solute carrier family 38, member 10
Synonyms: 1810073N04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72055
Homologene: 41556
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Ptger1
Name: prostaglandin E receptor 1 (subtype EP1)
Synonyms: EP1, 42kDa, Ptgerep1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19216
HGNC: HGNC:9593
Homologene: 738
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Zswim6
Name: zinc finger SWIM-type containing 6
Synonyms: 2900036G02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67263
VEGA: 13
Homologene: 83517
Prox1
Name: prospero homeobox 1
Synonyms: A230003G05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19130
HGNC: HGNC:9459
Homologene: 2069
Mpzl3
Name: myelin protein zero-like 3
Synonyms: A530065I17Rik, rc, ruf, 5430427F17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319742
Homologene: 18867
Ostm1
Name: osteopetrosis associated transmembrane protein 1
Synonyms: HSPC019, gl, 1200002H13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14628
Homologene: 32203
Ube2e3
Name: ubiquitin-conjugating enzyme E2E 3
Synonyms: ubcM2, Ubce4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22193
Homologene: 4636
Dctn2
Name: dynactin 2
Synonyms: C130077D06Rik, DCTN-50, p50, 2310042E05Rik, RBP50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69654
VEGA: 10
HGNC: HGNC:2712
Homologene: 4667
Diablo
Name: diablo, IAP-binding mitochondrial protein
Synonyms: 1700006L01Rik, Smac, 0610041G12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66593
Homologene: 10532
Ppp2r5c
Name: protein phosphatase 2, regulatory subunit B', gamma
Synonyms: 2700063L20Rik, Band 8A, 2610043M05Rik, D12Bwg0916e, B56/PP2A gamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26931
VEGA: 12
HGNC: HGNC:9311
Homologene: 128665
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Antxr2
Name: anthrax toxin receptor 2
Synonyms: CMG-2, cI-35, CMG2, 2310046B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71914
Homologene: 43236
Pip4p1
Name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Synonyms: Tmem55b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219024
Homologene: 10279
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, sy, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4921537P18Rik, 4930456F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70952
Homologene: 134158
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237887
Or10ak12
Name: olfactory receptor family 10 subfamily AK member 12
Synonyms: GA_x6K02T2QD9B-18726774-18727577, MOR259-5, Olfr1335, MOR259-12, GA_x6K02T2QD9B-18723799-18724749, Olfr1334-ps1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435804
Homologene: 138635
Rnpepl1
Name: arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms: 1110014H17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108657
Homologene: 36367
D2hgdh
Name: D-2-hydroxyglutarate dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98314
Homologene: 5534
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Cd101
Name: CD101 antigen
Synonyms: Igsf2, LOC381460
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50798
Homologene: 3996
Sult1e1
Name: sulfotransferase family 1E, member 1
Synonyms: Ste, EST
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20860
Homologene: 101388
Clec2g
Name: C-type lectin domain family 2, member g
Synonyms: Ocilrp1, 4632413B12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70809
Homologene: 136309
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67230
Homologene: 23459
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Itgal
Name: integrin alpha L
Synonyms: Ly-15, LFA-1, Ly-21, Cd11a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Myom2
Name: myomesin 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Or8g33
Name: olfactory receptor family 8 subfamily G member 33
Synonyms: MOR171-21, GA_x6K02T2PVTD-33124064-33123120, Olfr952
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235248
VEGA: 9
Homologene: 133698
Mei4
Name: meiotic double-stranded break formation protein 4
Synonyms: 4930486G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75033
Homologene: 87251
Trgv7
Name: T cell receptor gamma, variable 7
Synonyms: Tcrg-V7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21641
Vmn1r208
Name: vomeronasal 1 receptor 208
Synonyms: Vmn1r208-ps, V1rh9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171252
Homologene: 110880
Ccnb1ip1
Name: cyclin B1 interacting protein 1
Synonyms: LOC239083, mei4, Hei10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239083
VEGA: 14
Homologene: 18819
Lzts3
Name: leucine zipper, putative tumor suppressor family member 3
Synonyms: Prosapip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241638
Homologene: 8824
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 64,576,208 bp
  • T to A, chromosome 1 at 92,918,898 bp
  • G to T, chromosome 1 at 93,835,287 bp
  • A to T, chromosome 1 at 173,486,847 bp
  • A to G, chromosome 1 at 190,160,919 bp
  • C to A, chromosome 2 at 78,919,949 bp
  • T to A, chromosome 2 at 130,636,540 bp
  • T to A, chromosome 2 at 181,615,963 bp
  • A to G, chromosome 3 at 90,400,647 bp
  • A to G, chromosome 3 at 101,008,217 bp
  • T to C, chromosome 4 at 40,986,688 bp
  • A to C, chromosome 4 at 44,060,099 bp
  • A to T, chromosome 4 at 118,809,690 bp
  • A to G, chromosome 4 at 145,062,563 bp
  • A to T, chromosome 5 at 87,579,897 bp
  • T to A, chromosome 5 at 97,948,250 bp
  • A to T, chromosome 5 at 123,518,024 bp
  • A to G, chromosome 6 at 82,736,528 bp
  • A to T, chromosome 6 at 128,561,562 bp
  • T to A, chromosome 6 at 128,948,753 bp
  • T to C, chromosome 6 at 128,980,311 bp
  • A to T, chromosome 7 at 12,810,932 bp
  • A to C, chromosome 7 at 29,110,505 bp
  • T to C, chromosome 7 at 81,319,123 bp
  • C to T, chromosome 7 at 100,835,411 bp
  • A to G, chromosome 7 at 127,310,331 bp
  • A to G, chromosome 8 at 15,117,624 bp
  • T to C, chromosome 8 at 27,447,821 bp
  • A to T, chromosome 8 at 83,668,319 bp
  • T to A, chromosome 8 at 84,677,199 bp
  • A to G, chromosome 9 at 39,426,892 bp
  • T to C, chromosome 9 at 45,068,252 bp
  • C to T, chromosome 9 at 82,025,582 bp
  • C to A, chromosome 9 at 106,710,365 bp
  • A to C, chromosome 10 at 42,692,956 bp
  • A to T, chromosome 10 at 127,277,485 bp
  • A to G, chromosome 11 at 80,637,953 bp
  • A to G, chromosome 11 at 83,035,542 bp
  • A to T, chromosome 11 at 120,106,502 bp
  • A to T, chromosome 12 at 69,209,887 bp
  • A to T, chromosome 12 at 110,567,770 bp
  • A to G, chromosome 13 at 19,178,422 bp
  • A to T, chromosome 13 at 22,772,425 bp
  • A to G, chromosome 13 at 99,429,848 bp
  • T to C, chromosome 13 at 107,738,563 bp
  • T to C, chromosome 14 at 50,929,163 bp
  • A to T, chromosome 14 at 67,410,050 bp
  • G to A, chromosome 14 at 81,519,382 bp
  • A to T, chromosome 14 at 110,749,932 bp
  • T to C, chromosome 15 at 81,430,798 bp
  • G to A, chromosome 16 at 15,726,504 bp
  • T to C, chromosome 18 at 58,069,184 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0069 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038360-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.