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Strain Name:
C57BL/6J-MtgxR0070Btlr/Mmmh
Stock Number:
038361-MU
Citation ID:
RRID:MMRRC_038361-MU
Other Names:
R0070 (G1), C57BL/6J-MtgxR0070Btlr
Major Collection:

Strain Information

Itga6
Name: integrin alpha 6
Synonyms: Cd49f, 5033401O05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Ciapin1
Name: cytokine induced apoptosis inhibitor 1
Synonyms: anamorsin, 2810413N20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109006
Homologene: 10658
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: CGI-72, E130113K22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,801,103 bp
  • A to G, chromosome 1 at 87,101,159 bp
  • C to T, chromosome 1 at 110,098,372 bp
  • C to A, chromosome 1 at 182,473,869 bp
  • T to C, chromosome 2 at 25,892,362 bp
  • A to T, chromosome 2 at 29,161,525 bp
  • T to C, chromosome 2 at 71,826,716 bp
  • T to C, chromosome 2 at 76,814,427 bp
  • T to C, chromosome 2 at 127,257,059 bp
  • C to T, chromosome 3 at 92,457,302 bp
  • A to G, chromosome 4 at 63,356,646 bp
  • A to G, chromosome 4 at 88,820,275 bp
  • A to T, chromosome 4 at 103,059,934 bp
  • G to A, chromosome 4 at 124,714,955 bp
  • C to T, chromosome 4 at 128,585,882 bp
  • T to C, chromosome 5 at 23,964,999 bp
  • A to G, chromosome 5 at 29,225,127 bp
  • G to A, chromosome 5 at 45,733,701 bp
  • A to C, chromosome 5 at 52,756,918 bp
  • T to C, chromosome 5 at 104,466,990 bp
  • T to C, chromosome 5 at 107,901,900 bp
  • A to G, chromosome 5 at 147,372,726 bp
  • A to G, chromosome 5 at 149,209,705 bp
  • A to G, chromosome 6 at 30,519,421 bp
  • A to T, chromosome 6 at 38,295,190 bp
  • G to A, chromosome 6 at 38,818,984 bp
  • G to A, chromosome 6 at 68,161,418 bp
  • A to G, chromosome 6 at 72,358,759 bp
  • T to C, chromosome 7 at 3,158,898 bp
  • T to C, chromosome 7 at 28,889,126 bp
  • T to C, chromosome 7 at 30,728,101 bp
  • A to G, chromosome 7 at 49,570,714 bp
  • A to T, chromosome 7 at 99,349,314 bp
  • T to G, chromosome 7 at 107,844,917 bp
  • T to C, chromosome 7 at 126,447,452 bp
  • G to A, chromosome 8 at 39,063,267 bp
  • T to A, chromosome 8 at 72,725,582 bp
  • T to C, chromosome 8 at 94,825,219 bp
  • T to A, chromosome 8 at 117,426,554 bp
  • C to T, chromosome 9 at 44,707,904 bp
  • T to A, chromosome 9 at 54,922,348 bp
  • C to T, chromosome 9 at 58,152,615 bp
  • C to T, chromosome 9 at 100,956,408 bp
  • A to T, chromosome 9 at 110,727,550 bp
  • A to G, chromosome 11 at 66,160,040 bp
  • A to G, chromosome 11 at 75,660,250 bp
  • T to A, chromosome 11 at 77,553,717 bp
  • A to T, chromosome 11 at 89,392,302 bp
  • C to G, chromosome 11 at 99,015,060 bp
  • T to A, chromosome 11 at 103,239,554 bp
  • A to G, chromosome 11 at 106,311,918 bp
  • T to C, chromosome 12 at 29,982,727 bp
  • T to A, chromosome 12 at 44,222,362 bp
  • T to A, chromosome 12 at 81,379,066 bp
  • T to C, chromosome 13 at 21,611,261 bp
  • A to T, chromosome 14 at 51,414,140 bp
  • T to C, chromosome 14 at 108,913,317 bp
  • T to G, chromosome 15 at 66,639,991 bp
  • A to G, chromosome 15 at 75,237,585 bp
  • A to G, chromosome 15 at 82,760,774 bp
  • A to T, chromosome 16 at 3,988,016 bp
  • C to A, chromosome 16 at 94,941,197 bp
  • T to A, chromosome 17 at 22,146,184 bp
  • T to A, chromosome 17 at 29,340,059 bp
  • A to G, chromosome 17 at 38,130,889 bp
  • T to C, chromosome 17 at 55,802,154 bp
  • G to A, chromosome 17 at 64,659,079 bp
  • A to G, chromosome 17 at 78,954,510 bp
  • T to C, chromosome 18 at 63,102,084 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0070 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038361-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.