Strain Name:
C57BL/6J-MtgxR0070Btlr/Mmmh
Stock Number:
038361-MU
Citation ID:
RRID:MMRRC_038361-MU
Other Names:
R0070 (G1), C57BL/6J-MtgxR0070Btlr
Major Collection:

Strain Information

Itga6
Name: integrin alpha 6
Synonyms: 5033401O05Rik, Cd49f
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Prkd3
Name: protein kinase D3
Synonyms: PKD3, 4930557O20Rik, Prkcn, 5730497N19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Ciapin1
Name: cytokine induced apoptosis inhibitor 1
Synonyms: 2810413N20Rik, anamorsin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109006
Homologene: 10658
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: E130113K22Rik, CGI-72
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21973
Homologene: 830
Nav2
Name: neuron navigator 2
Synonyms: Rainb1, POMFIL2, Unc53H2, 5330421F07Rik, HELAD1, RAINB2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Sf3a3
Name: splicing factor 3a, subunit 3
Synonyms: 60kDa, 4930512K19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75062
Homologene: 4949
Stag1
Name: STAG1 cohesin complex component
Synonyms: SA-1, Scc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20842
Homologene: 21191
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: 1110014O20Rik, Stank, B230339E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Mtch1
Name: mitochondrial carrier 1
Synonyms: 2310034O17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56462
Homologene: 22807
Pi4k2b
Name: phosphatidylinositol 4-kinase type 2 beta
Synonyms: 4933409G22Rik, 2610042N09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67073
Homologene: 32405
Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
Synonyms: Nik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53859
HGNC: HGNC:6853
Homologene: 2940
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana2, Mana-2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: PC2, polycystin-2, C030034P18Rik, TRPP2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Cmip
Name: c-Maf inducing protein
Synonyms: 4933407C03Rik, 5830471E12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74440
Homologene: 18869
Tusc3
Name: tumor suppressor candidate 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80286
Homologene: 6937
Lcorl
Name: ligand dependent nuclear receptor corepressor-like
Synonyms: A830039H10Rik, Mlr1, Gm3414
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041576
Homologene: 82325
Slitrk1
Name: SLIT and NTRK-like family, member 1
Synonyms: 3200001I04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76965
VEGA: 14
Homologene: 14174
Stra6
Name: stimulated by retinoic acid gene 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20897
Homologene: 7554
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: wmfl, Flk-2, Flk2, Flt-3, CD135
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Rpl5
Name: ribosomal protein L5
Synonyms: Ska23, Skax23, Skam23Jus, U21RNA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503670
Homologene: 110649
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Orm3
Name: orosomucoid 3
Synonyms: Agp-3, Orm-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18407
Homologene: 130632
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231915
Homologene: 4235
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Capn12
Name: calpain 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60594
Homologene: 77333
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52864
Homologene: 23770
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Rnf32
Name: ring finger protein 32
Synonyms: 2700025B22Rik, 1700009J01Rik, Lmbr2, 4930542N22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56874
Homologene: 10986
Atp2a1
Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Synonyms: SERCA1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11937
HGNC: HGNC:811
Homologene: 7635
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Alpi
Name: alkaline phosphatase, intestinal
Synonyms: 2010001C14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76768
Homologene: 122414
4932411E22Rik
Name: RIKEN cDNA 4932411E22 gene
Type: Gene
Species: Mouse
Chromosome: 11
Kansl1l
Name: KAT8 regulatory NSL complex subunit 1-like
Synonyms: 1110028C15Rik, C430010P07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68691
Homologene: 27376
Capn2
Name: calpain 2
Synonyms: Capa-2, m-calpain, Capa2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: Slack, C030030G16Rik, slo2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227632
Homologene: 11055
Tmem127
Name: transmembrane protein 127
Synonyms: 2310003P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69470
Homologene: 9877
Sprr3
Name: small proline-rich protein 3
Synonyms: SPR3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20766
Homologene: 135951
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242584
Homologene: 11702
Hycc1
Name: hyccin PI4KA lipid kinase complex subunit 1
Synonyms: hyccin, Fam126a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 84652
Homologene: 57175
Ssmem1
Name: serine-rich single-pass membrane protein 1
Synonyms: 1700025E21Rik, 1700016K02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75647
Homologene: 12615
Zc3hav1l
Name: zinc finger CCCH-type, antiviral 1-like
Synonyms: E430016P22Rik, B130055L09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209032
Homologene: 15425
Igkv1-115
Name: immunoglobulin kappa variable 1-115
Synonyms: Gm6854
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 628206
Tmem150a
Name: transmembrane protein 150A
Synonyms: Tmem150
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232086
Homologene: 16378
AU018091
Name: expressed sequence AU018091
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245128
Homologene: 106376
Tmem147
Name: transmembrane protein 147
Synonyms: 5033425B17Rik, 2010004E11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69804
Homologene: 12330
Serpinh1
Name: serine (or cysteine) peptidase inhibitor, clade H, member 1
Synonyms: Cbp1, Hsp47, Cbp2, J6, colligin, gp46, Serpinh2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12406
HGNC: HGNC:1546
Homologene: 20331
Or5p51
Name: olfactory receptor family 5 subfamily P member 51
Synonyms: Olfr470, GA_x6K02T2PBJ9-10175273-10174329, MOR204-22
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258417
Hykk
Name: hydroxylysine kinase 1
Synonyms: Agphd1, C630028N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235386
Homologene: 16057
Pth1r
Name: parathyroid hormone 1 receptor
Synonyms: PTH1R, PPR, PTH/PTHrP receptor, PTH-related peptide receptor, Pthr1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19228
HGNC: HGNC:9608
Homologene: 267
Myo1c
Name: myosin IC
Synonyms: mm1beta, C80397, myr2, myosin-Ibeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Cd79b
Name: CD79B antigen
Synonyms: Igb, Igbeta, Ig-beta, B29
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15985
HGNC: HGNC:1699
Homologene: 521
Pxdn
Name: peroxidasin
Synonyms: VPO1, 2310075M15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Gm2027
Name: predicted gene 2027
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100039062
VEGA: 12
Gm4787
Name: predicted gene 4787
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 214321
Homologene: 86950
Or2w4
Name: olfactory receptor family 2 subfamily W member 4
Synonyms: Olfr1363-ps1, GA_x6K02T2QHY8-11628399-11628868, GA_x6K02T2QHY8-11617756-11618682, Olfr1362, MOR256-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258739
Homologene: 105885
Gm10238
Name: predicted pseudogene 10238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100041092
Cyp2d40
Name: cytochrome P450, family 2, subfamily d, polypeptide 40
Synonyms: 1300013D18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71754
VEGA: 15
Homologene: 135470
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, KCNJ7, GIRK2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Zfp947
Name: zinc finger protein 947
Synonyms: Gm4769
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210853
Homologene: 133253
Or2h15
Name: olfactory receptor family 2 subfamily H member 15
Synonyms: GA_x6K02T2PSCP-2579687-2578746, MOR256-49, Olfr132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 257889
Homologene: 46430
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: D17Ertd479e, Emr4, Gpr127, FIRE, EGF-TM7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Fam38b
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,801,103 bp
  • A to G, chromosome 1 at 87,101,159 bp
  • C to T, chromosome 1 at 110,098,372 bp
  • C to A, chromosome 1 at 182,473,869 bp
  • T to C, chromosome 2 at 25,892,362 bp
  • A to T, chromosome 2 at 29,161,525 bp
  • T to C, chromosome 2 at 71,826,716 bp
  • T to C, chromosome 2 at 76,814,427 bp
  • T to C, chromosome 2 at 127,257,059 bp
  • C to T, chromosome 3 at 92,457,302 bp
  • A to G, chromosome 4 at 63,356,646 bp
  • A to G, chromosome 4 at 88,820,275 bp
  • A to T, chromosome 4 at 103,059,934 bp
  • G to A, chromosome 4 at 124,714,955 bp
  • C to T, chromosome 4 at 128,585,882 bp
  • T to C, chromosome 5 at 23,964,999 bp
  • A to G, chromosome 5 at 29,225,127 bp
  • G to A, chromosome 5 at 45,733,701 bp
  • A to C, chromosome 5 at 52,756,918 bp
  • T to C, chromosome 5 at 104,466,990 bp
  • T to C, chromosome 5 at 107,901,900 bp
  • A to G, chromosome 5 at 147,372,726 bp
  • A to G, chromosome 5 at 149,209,705 bp
  • A to G, chromosome 6 at 30,519,421 bp
  • A to T, chromosome 6 at 38,295,190 bp
  • G to A, chromosome 6 at 38,818,984 bp
  • G to A, chromosome 6 at 68,161,418 bp
  • A to G, chromosome 6 at 72,358,759 bp
  • T to C, chromosome 7 at 3,158,898 bp
  • T to C, chromosome 7 at 28,889,126 bp
  • T to C, chromosome 7 at 30,728,101 bp
  • A to G, chromosome 7 at 49,570,714 bp
  • A to T, chromosome 7 at 99,349,314 bp
  • T to G, chromosome 7 at 107,844,917 bp
  • T to C, chromosome 7 at 126,447,452 bp
  • G to A, chromosome 8 at 39,063,267 bp
  • T to A, chromosome 8 at 72,725,582 bp
  • T to C, chromosome 8 at 94,825,219 bp
  • T to A, chromosome 8 at 117,426,554 bp
  • C to T, chromosome 9 at 44,707,904 bp
  • T to A, chromosome 9 at 54,922,348 bp
  • C to T, chromosome 9 at 58,152,615 bp
  • C to T, chromosome 9 at 100,956,408 bp
  • A to T, chromosome 9 at 110,727,550 bp
  • A to G, chromosome 11 at 66,160,040 bp
  • A to G, chromosome 11 at 75,660,250 bp
  • T to A, chromosome 11 at 77,553,717 bp
  • A to T, chromosome 11 at 89,392,302 bp
  • C to G, chromosome 11 at 99,015,060 bp
  • T to A, chromosome 11 at 103,239,554 bp
  • A to G, chromosome 11 at 106,311,918 bp
  • T to C, chromosome 12 at 29,982,727 bp
  • T to A, chromosome 12 at 44,222,362 bp
  • T to A, chromosome 12 at 81,379,066 bp
  • T to C, chromosome 13 at 21,611,261 bp
  • A to T, chromosome 14 at 51,414,140 bp
  • T to C, chromosome 14 at 108,913,317 bp
  • T to G, chromosome 15 at 66,639,991 bp
  • A to G, chromosome 15 at 75,237,585 bp
  • A to G, chromosome 15 at 82,760,774 bp
  • A to T, chromosome 16 at 3,988,016 bp
  • C to A, chromosome 16 at 94,941,197 bp
  • T to A, chromosome 17 at 22,146,184 bp
  • T to A, chromosome 17 at 29,340,059 bp
  • A to G, chromosome 17 at 38,130,889 bp
  • T to C, chromosome 17 at 55,802,154 bp
  • G to A, chromosome 17 at 64,659,079 bp
  • A to G, chromosome 17 at 78,954,510 bp
  • T to C, chromosome 18 at 63,102,084 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0070 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038361-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.