Strain Name:
C57BL/6J-MtgxR0085Btlr/Mmmh
Stock Number:
038372-MU
Citation ID:
RRID:MMRRC_038372-MU
Other Names:
R0085 (G1), C57BL/6J-MtgxR0085Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC-1, PC1, polycystin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Adcy9
Name: adenylate cyclase 9
Synonyms: ACtp10, D16Wsu65e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Dst
Name: dystonin
Synonyms: Bpag1, Bpag, 2310001O04Rik, nmf339, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, Macf2, nmf203, bullous pemphigoid antigen 1, athetoid, A830042E19Rik, ah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74200
Homologene: 41761
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: D5Bwg1524e, 2410098H20Rik, Rutbc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52850
Homologene: 64485
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Lrrc16, 1110037D04Rik, Lrrc16a, Carmil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: b2b449Clo, Map3k7ip1, Tak1-binding protein 1, 2310012M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108989
Homologene: 37753
Brd2
Name: bromodomain containing 2
Synonyms: Fsrg1, Ring3, Rnf3, D17H6S113E, Frg-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14312
HGNC: HGNC:1103
Homologene: 74540
Picalm
Name: phosphatidylinositol binding clathrin assembly protein
Synonyms: fit1, fit-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233489
Homologene: 111783
Ass1
Name: argininosuccinate synthetase 1
Synonyms: Ass-1, ASS, fold
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: KGFRTr, Fgfr-2, Fgfr-7, svs, Bek, Fgfr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Zbtb18
Name: zinc finger and BTB domain containing 18
Synonyms: RP58, Zfp238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 30928
Homologene: 21276
Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Synonyms: retSDR3, 0610039E24Rik, Dhrs10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66065
Homologene: 133800
Clvs2
Name: clavesin 2
Synonyms: A330019N05Rik, Rlbp1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215890
Homologene: 27894
Cfi
Name: complement component factor i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: LigI, mLigI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Zfp791
Name: zinc finger protein 791
Synonyms: EG244556
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244556
Homologene: 27420
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Efcab7
Name: EF-hand calcium binding domain 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230500
Homologene: 19952
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
Nox3
Name: NADPH oxidase 3
Synonyms: het, nmf250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224480
HGNC: HGNC:7890
Homologene: 49435
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108151
Homologene: 23664
Bpi
Name: bactericidal permeablility increasing protein
Synonyms: 9230105K17Rik, Bpifd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329547
HGNC: HGNC:1095
Homologene: 37519
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: Ntup1, MP-1, 2310012C15Rik, PreP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69617
VEGA: 13
Homologene: 5742
4933424B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94229
Homologene: 23340
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: ORP-6, 1110062M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99031
Homologene: 101447
Ogfr
Name: opioid growth factor receptor
Synonyms: 2010013E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72075
Homologene: 7199
Baat
Name: bile acid-Coenzyme A: amino acid N-acyltransferase
Synonyms: taurine N-acyltransferase, BAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12012
HGNC: HGNC:932
Homologene: 1286
Olfr1341
Name: olfactory receptor 1341
Synonyms: MOR258-1, GA_x6K02T2QD9B-18838170-18837232
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258852
Homologene: 27281
Fbxo2
Name: F-box protein 2
Synonyms: FBX2, NFB42, Fbs1, Prpl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230904
Homologene: 8132
Acad12
Name: acyl-Coenzyme A dehydrogenase family, member 12
Synonyms: 9330129D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 338350
Upk3bl
Name: uroplakin 3B-like
Synonyms: 2310043J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69665
Homologene: 78581
Pnmal2
Name: PNMA-like 2
Synonyms: EG434128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434128
Homologene: 35491
Plekha4
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
Synonyms: PEPP1, 2410005C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69217
Homologene: 10848
Ush1c
Name: USH1 protein network component harmonin
Synonyms: Usher syndrome 1C, harmonin, 2010016F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72088
Homologene: 77476
Cd209g
Name: CD209g antigen
Synonyms: 2310066I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70192
Homologene: 137382
Fam38a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Olfr904
Name: olfactory receptor 904
Synonyms: MOR167-3, GA_x6K02T2PVTD-32156773-32157705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258797
VEGA: 9
Homologene: 133629
Tmem30a
Name: transmembrane protein 30A
Synonyms: D9Wsu20e, Cdc50a, 2010200I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69981
Homologene: 110703
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55963
Homologene: 20655
Mgat4b
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103534
HGNC: HGNC:7048
Homologene: 8611
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: Nadc1, mNaDC-1, sodium/dicarboxylate co-transporter
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20500
Homologene: 2965
Zfp712
Name: zinc finger protein 712
Synonyms: 4921504N20Rik, mszf31, mszf89
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78251
VEGA: 13
Homologene: 136296
Olfr741
Name: olfactory receptor 741
Synonyms: MOR106-15, GA_x6K02T2PMLR-6197851-6198786, MOR106-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258233
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,229,187 bp
  • A to C, chromosome 1 at 150,417,413 bp
  • C to T, chromosome 1 at 177,447,935 bp
  • A to T, chromosome 2 at 31,514,819 bp
  • G to A, chromosome 2 at 62,244,346 bp
  • G to T, chromosome 2 at 76,593,414 bp
  • T to C, chromosome 2 at 91,162,738 bp
  • A to G, chromosome 2 at 112,859,763 bp
  • T to A, chromosome 2 at 158,273,152 bp
  • A to G, chromosome 2 at 180,591,037 bp
  • T to A, chromosome 3 at 88,711,739 bp
  • A to G, chromosome 3 at 129,874,986 bp
  • T to C, chromosome 4 at 49,490,425 bp
  • T to C, chromosome 4 at 99,904,680 bp
  • T to C, chromosome 4 at 118,709,881 bp
  • T to C, chromosome 4 at 148,164,910 bp
  • G to A, chromosome 5 at 12,570,986 bp
  • A to G, chromosome 5 at 113,279,270 bp
  • A to G, chromosome 5 at 121,604,294 bp
  • A to G, chromosome 5 at 136,060,115 bp
  • T to C, chromosome 6 at 67,486,222 bp
  • T to A, chromosome 6 at 146,574,787 bp
  • A to G, chromosome 7 at 13,307,570 bp
  • A to T, chromosome 7 at 16,945,549 bp
  • C to T, chromosome 7 at 45,543,949 bp
  • T to C, chromosome 7 at 45,556,410 bp
  • T to A, chromosome 7 at 46,225,555 bp
  • T to A, chromosome 7 at 90,182,317 bp
  • C to A, chromosome 7 at 130,196,263 bp
  • A to T, chromosome 8 at 4,134,785 bp
  • G to T, chromosome 8 at 85,112,233 bp
  • A to G, chromosome 8 at 122,501,615 bp
  • T to C, chromosome 9 at 38,464,662 bp
  • T to A, chromosome 9 at 79,771,294 bp
  • G to C, chromosome 10 at 33,622,546 bp
  • A to G, chromosome 11 at 20,304,510 bp
  • C to T, chromosome 11 at 50,230,999 bp
  • A to G, chromosome 11 at 78,406,868 bp
  • C to T, chromosome 13 at 6,549,568 bp
  • T to A, chromosome 13 at 24,025,867 bp
  • T to C, chromosome 13 at 67,041,192 bp
  • C to A, chromosome 14 at 33,078,243 bp
  • T to A, chromosome 14 at 50,486,334 bp
  • C to T, chromosome 14 at 64,022,295 bp
  • G to T, chromosome 15 at 80,155,893 bp
  • T to C, chromosome 16 at 4,288,224 bp
  • C to A, chromosome 16 at 14,224,019 bp
  • T to C, chromosome 17 at 3,635,281 bp
  • T to C, chromosome 17 at 24,586,223 bp
  • A to C, chromosome 17 at 34,113,259 bp
  • A to C, chromosome 18 at 74,701,680 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0085 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038372-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.