Strain Name:
C57BL/6J-MtgxR0086Btlr/Mmmh
Stock Number:
038373-MU
Citation ID:
RRID:MMRRC_038373-MU
Other Names:
R0086 (G1), C57BL/6J-MtgxR0086Btlr
Major Collection:

Gene Information

Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22241
Homologene: 2640
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67812
Homologene: 40962
Cog6
Name: component of oligomeric golgi complex 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67542
Homologene: 10802
Mtrex
Name: Mtr4 exosome RNA helicase
Synonyms: 2610528A15Rik, Skiv2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72198
VEGA: 13
Homologene: 6257
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329908
Homologene: 35420
Abcg8
Name: ATP binding cassette subfamily G member 8
Synonyms: 1300003C16Rik, Sterolin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67470
Homologene: 23361
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Capza2
Name: capping protein (actin filament) muscle Z-line, alpha 2
Synonyms: Cappa2, 1110053K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12343
HGNC: HGNC:1490
Homologene: 55956
Bcl2
Name: B cell leukemia/lymphoma 2
Synonyms: Bcl-2, C430015F12Rik, D830018M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12043
HGNC: HGNC:990
Homologene: 527
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Numb
Name: NUMB endocytic adaptor protein
Synonyms: m-numb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18222
HGNC: HGNC:8060
Homologene: 2775
Trmt6
Name: tRNA methyltransferase 6
Synonyms: 3300001M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66926
Homologene: 6816
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78912
Homologene: 2340
Tpm3
Name: tropomyosin 3, gamma
Synonyms: hTMnm, hTM30nm, gamma-TM, skalphaTM.2, Tpm-5, Trop-5, Tpm5, Tm5NM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 59069
Homologene: 81889
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Map3k2
Name: mitogen-activated protein kinase kinase kinase 2
Synonyms: Mekk2, MEK kinase 2, 9630061B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 26405
VEGA: 18
HGNC: HGNC:6854
Homologene: 74576
Snap29
Name: synaptosomal-associated protein 29
Synonyms: 1300018G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67474
Homologene: 3512
Oip5
Name: Opa interacting protein 5
Synonyms: 5730547N13Rik, Lint-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70645
Homologene: 5268
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: MFT.M05.13, Hcapg, 5730507H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54392
Homologene: 44071
Cercam
Name: cerebral endothelial cell adhesion molecule
Synonyms: CerCAM, Ceecam1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99151
Homologene: 22954
Exph5
Name: exophilin 5
Synonyms: slac2-b, B130009M24Rik, AC079869.22gm5, Slac2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320051
Homologene: 9007
Olfr639
Name: olfactory receptor 639
Synonyms: GA_x6K02T2PBJ9-6747143-6746193, MOR12-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259088
Homologene: 17497
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: D7Ertd565e, Nalp-theta, Nalp9a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233001
Homologene: 116072
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Ap4b1
Name: adaptor-related protein complex AP-4, beta 1
Synonyms: AP-4 beta-4, 1810038H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67489
HGNC: HGNC:572
Homologene: 38203
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Plcl1
Name: phospholipase C-like 1
Synonyms: PLC-L, C230017K02Rik, PRIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69675
Homologene: 33907
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Tmbim1
Name: transmembrane BAX inhibitor motif containing 1
Synonyms: 2310061B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69660
Homologene: 36404
Olfr342
Name: olfactory receptor 342
Synonyms: GA_x6K02T2NLDC-33222024-33222962, MOR136-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258950
Homologene: 74223
Hoxd8
Name: homeobox D8
Synonyms: Hox-4.3, 4921540P06Rik, Hox-5.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15437
HGNC: HGNC:5139
Homologene: 10473
Olfr1224-ps1
Name: olfactory receptor 1224, pseudogene 1
Synonyms: GA_x6K02T2Q125-50635980-50635046, MOR233-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258026
Rtraf-ps
Name: RNA transcription, translation and transport factor, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545536
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, Myo, 1110069I04Rik, 9530006G20Rik, 2310068J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 118449
Homologene: 15400
C330019G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
C1galt1
Name: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
Synonyms: core 1 beta3-Gal-T, 2210410E06Rik, T-synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94192
Homologene: 10599
Lmod3
Name: leiomodin 3 (fetal)
Synonyms: 5430424A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320502
HGNC: HGNC:6649
Homologene: 28097
Mkrn2
Name: makorin, ring finger protein, 2
Synonyms: 2610002L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67027
HGNC: HGNC:7113
Homologene: 8392
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: mENaC, ENaC alpha, Scnn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20276
Homologene: 811
Tuba3b
Name: tubulin, alpha 3B
Synonyms: M[a]7, Tuba7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22147
Homologene: 128229
Shkbp1
Name: Sh3kbp1 binding protein 1
Synonyms: SB1, B930062H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 192192
Homologene: 26700
Polr2i
Name: polymerase (RNA) II (DNA directed) polypeptide I
Synonyms: 2810002B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69920
HGNC: HGNC:9196
Homologene: 4541
CT025680.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Slc22a13b
Name: solute carrier family 22 (organic cation transporter), member 13b
Synonyms: Slc22a13b-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109280
Gns
Name: glucosamine (N-acetyl)-6-sulfatase
Synonyms: G6S, 2610016K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75612
VEGA: 10
HGNC: HGNC:4422
Homologene: 1568
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Gjc2
Name: gap junction protein, gamma 2
Synonyms: connexin 47, Cx47, B230382L12Rik, Gja12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 118454
Homologene: 10715
Mfsd6l
Name: major facilitator superfamily domain containing 6-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215723
Homologene: 17128
Zmynd15
Name: zinc finger, MYND-type containing 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574428
Homologene: 12995
Pcnx
Name: pecanex homolog
Synonyms: 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Cts6
Name: cathepsin 6
Synonyms: 1600022N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 58518
Homologene: 75165
Micall1
Name: microtubule associated monooxygenase, calponin and LIM domain containing -like 1
Synonyms: Mus EST 820961, D15N2e, D15Mit260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27008
VEGA: 15
Homologene: 24911
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Trp63
Name: transformation related protein 63
Synonyms: KET protein, p63, p73L, Trp53rp1, TAp63, p51/p63, deltaNp63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22061
Homologene: 31189
Cyp2c39
Name: cytochrome P450, family 2, subfamily c, polypeptide 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13098
HGNC: HGNC:2622
Homologene: 117948
Ina
Name: internexin neuronal intermediate filament protein, alpha
Synonyms: NF-66, NF66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226180
HGNC: HGNC:6057
Homologene: 10433
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 55,715,583 bp
  • T to C, chromosome 1 at 74,289,928 bp
  • G to A, chromosome 1 at 106,712,562 bp
  • G to A, chromosome 1 at 128,262,904 bp
  • T to C, chromosome 2 at 29,871,064 bp
  • A to T, chromosome 2 at 36,527,450 bp
  • G to T, chromosome 2 at 74,705,932 bp
  • C to T, chromosome 2 at 89,156,476 bp
  • C to T, chromosome 2 at 119,617,929 bp
  • CTG to C, chromosome 2 at 132,809,017 bp
  • A to G, chromosome 3 at 52,993,570 bp
  • C to T, chromosome 3 at 88,576,880 bp
  • T to A, chromosome 3 at 90,090,092 bp
  • T to G, chromosome 3 at 103,814,860 bp
  • A to T, chromosome 3 at 123,117,104 bp
  • C to T, chromosome 3 at 135,264,424 bp
  • A to T, chromosome 4 at 98,945,144 bp
  • T to C, chromosome 4 at 106,392,360 bp
  • T to A, chromosome 5 at 32,831,559 bp
  • A to G, chromosome 5 at 45,676,744 bp
  • G to A, chromosome 5 at 110,787,707 bp
  • T to A, chromosome 6 at 7,867,051 bp
  • A to G, chromosome 6 at 17,660,774 bp
  • T to A, chromosome 6 at 97,247,345 bp
  • G to T, chromosome 6 at 115,613,335 bp
  • T to C, chromosome 6 at 125,342,587 bp
  • T to A, chromosome 6 at 145,621,160 bp
  • G to A, chromosome 7 at 26,558,547 bp
  • G to T, chromosome 7 at 27,352,026 bp
  • G to A, chromosome 7 at 30,233,086 bp
  • A to G, chromosome 7 at 104,012,054 bp
  • C to T, chromosome 8 at 40,826,360 bp
  • T to A, chromosome 8 at 69,797,774 bp
  • T to C, chromosome 9 at 39,046,895 bp
  • A to G, chromosome 9 at 53,337,930 bp
  • C to T, chromosome 9 at 119,222,738 bp
  • T to C, chromosome 10 at 93,028,594 bp
  • G to A, chromosome 10 at 121,391,473 bp
  • C to A, chromosome 10 at 127,087,882 bp
  • A to T, chromosome 11 at 59,176,846 bp
  • A to G, chromosome 11 at 68,556,565 bp
  • T to C, chromosome 11 at 70,464,232 bp
  • C to A, chromosome 11 at 96,957,427 bp
  • G to T, chromosome 12 at 30,002,419 bp
  • T to C, chromosome 12 at 81,992,058 bp
  • T to C, chromosome 12 at 83,795,930 bp
  • A to T, chromosome 13 at 61,196,457 bp
  • G to T, chromosome 13 at 112,927,328 bp
  • T to A, chromosome 15 at 44,556,008 bp
  • T to C, chromosome 15 at 79,125,489 bp
  • T to A, chromosome 15 at 82,062,601 bp
  • C to A, chromosome 16 at 14,224,019 bp
  • C to A, chromosome 16 at 17,428,236 bp
  • A to G, chromosome 16 at 21,914,225 bp
  • T to C, chromosome 16 at 25,871,087 bp
  • T to C, chromosome 17 at 73,884,438 bp
  • T to C, chromosome 17 at 74,593,166 bp
  • T to C, chromosome 17 at 84,692,771 bp
  • A to T, chromosome 18 at 32,218,468 bp
  • A to T, chromosome 19 at 39,510,913 bp
  • A to G, chromosome 19 at 47,023,591 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0086 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038373-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.