Strain Name:
C57BL/6J-MtgxR0095Btlr/Mmmh
Stock Number:
038381-MU
Citation ID:
RRID:MMRRC_038381-MU
Other Names:
R0095 (G1), C57BL/6J-MtgxR0095Btlr
Major Collection:

Gene Information

Itk
Name: IL2 inducible T cell kinase
Synonyms: Emt, Tsk, Tcsk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051
Kdm1a
Name: lysine (K)-specific demethylase 1A
Synonyms: Kdm1, 1810043O07Rik, Aof2, LSD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 99982
Homologene: 32240
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: 6330590F17Rik, D5Ertd483e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100756
Homologene: 32789
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328977
Homologene: 138627
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, Etl-4, Skt, E330027G05Rik, 6620402G01Rik, 9430077C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Rpap3
Name: RNA polymerase II associated protein 3
Synonyms: D15Ertd682e, 2310042P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71919
VEGA: 15
Homologene: 11613
Fer
Name: fer (fms/fps related) protein kinase
Synonyms: Fert2, C330004K01Rik, Fert
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14158
VEGA: 17
HGNC: HGNC:3655
Homologene: 74300
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, Tg(AMH-cre)1Flor, 2810431N21Rik, AMH-Cre, Gt(Ayu21)9Imeg, Ayu21-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Lypla1
Name: lysophospholipase 1
Synonyms: Pla1a, Gm39587
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18777
HGNC: HGNC:6737
Homologene: 100781
Sgo2a
Name: shugoshin 2A
Synonyms: 1110007N04Rik, Tripin, Sgol2, D1Ertd8e, Sgol2a, 5730576N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68549
Homologene: 51867
Unc45a
Name: unc-45 myosin chaperone A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101869
Homologene: 32423
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: jcpk, Bic-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83675
Homologene: 12856
Gpr3
Name: G-protein coupled receptor 3
Synonyms: Gpcr21, Gpcr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14748
HGNC: HGNC:4484
Homologene: 31303
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Rpl6
Name: ribosomal protein L6
Synonyms: Taxreb107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19988
Homologene: 31001
Hnrnpa3
Name: heterogeneous nuclear ribonucleoprotein A3
Synonyms: Hnrpa3, 2610209F03Rik, 2410013L13Rik, 2610510D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229279
Homologene: 138303
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545471
Homologene: 134546
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+/K+-ATPase alpha, H+K+-transporting alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Rfx8
Name: regulatory factor X 8
Synonyms: 4933400N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 619289
Homologene: 82436
Foxp2
Name: forkhead box P2
Synonyms: D0Kist7, 2810043D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Cutc
Name: cutC copper transporter
Synonyms: 2310039I18Rik, CGI-32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66388
Homologene: 9318
F5
Name: coagulation factor V
Synonyms: Cf5, Cf-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Myl3
Name: myosin, light polypeptide 3
Synonyms: MLC1s, Mylc, MLC1v, slow skeletal, ventricular, alkali
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17897
HGNC: HGNC:7584
Homologene: 20099
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr4, A630054M16Rik, ZIZ3, Zizimin3, Jr5, 9330153B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210293
Homologene: 45952
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108151
Homologene: 23664
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Naip, Birc1a, D13Lsd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Acpp
Name: acid phosphatase, prostate
Synonyms: A030005E02Rik, PAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56318
HGNC: HGNC:125
Homologene: 55552
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, 1110001D15Rik, Vwa6, EG235580
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Adhfe1
Name: alcohol dehydrogenase, iron containing, 1
Synonyms: 6330565B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76187
Homologene: 5865
Arhgef4
Name: Rho guanine nucleotide exchange factor (GEF) 4
Synonyms: Asef, C230030N03Rik, 9330140K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cchb2, Cavbeta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Gstm7
Name: glutathione S-transferase, mu 7
Synonyms: Cd203c, 0610005A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68312
HGNC: HGNC:4634
Homologene: 41816
Necab1
Name: N-terminal EF-hand calcium binding protein 1
Synonyms: NECAB1, 1700003H21Rik, STIP-1, Efcbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69352
Homologene: 11172
Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
Synonyms: D330017N19Rik, Srd5a2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243078
Homologene: 27549
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Gys1
Name: glycogen synthase 1, muscle
Synonyms: MGS, Gys3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14936
HGNC: HGNC:4706
Homologene: 113557
Olfr510
Name: olfactory receptor 510
Synonyms: GA_x6K02T2PBJ9-10997715-10998659, MOR204-34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258308
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244650
Homologene: 71015
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Aldh3a2
Name: aldehyde dehydrogenase family 3, subfamily A2
Synonyms: Ahd-3, Ahd3, Aldh4, Ahd3-r, Ahd-3r, FALDH, Aldh4-r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11671
HGNC: HGNC:403
Homologene: 55458
Cmah
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase
Synonyms: CMP-NeuAc hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12763
HGNC: HGNC:2098
Homologene: 7269
Anxa8
Name: annexin A8
Synonyms: Anx8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11752
Homologene: 20393
Lratd2
Name: LRAT domain containing 1
Synonyms: Fam84b, D330050I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 399603
Homologene: 18379
Tpsg1
Name: tryptase gamma 1
Synonyms: Prss31, TMT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26945
Homologene: 74994
Clcf1
Name: cardiotrophin-like cytokine factor 1
Synonyms: CLC, Bsf3, NNT-1/BSF-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56708
Homologene: 8299
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,830,327 bp
  • T to C, chromosome 1 at 9,560,177 bp
  • C to T, chromosome 1 at 34,732,370 bp
  • C to T, chromosome 1 at 39,685,536 bp
  • T to A, chromosome 1 at 58,015,555 bp
  • A to T, chromosome 1 at 80,524,071 bp
  • A to T, chromosome 1 at 164,191,968 bp
  • G to T, chromosome 2 at 14,958,775 bp
  • A to G, chromosome 2 at 20,743,868 bp
  • A to T, chromosome 2 at 26,425,760 bp
  • G to T, chromosome 2 at 75,661,696 bp
  • T to A, chromosome 2 at 150,472,300 bp
  • A to T, chromosome 3 at 59,331,196 bp
  • A to T, chromosome 3 at 107,930,563 bp
  • T to A, chromosome 4 at 14,960,027 bp
  • T to A, chromosome 4 at 133,211,286 bp
  • C to T, chromosome 4 at 136,550,894 bp
  • T to C, chromosome 5 at 12,563,347 bp
  • T to C, chromosome 5 at 83,294,570 bp
  • T to A, chromosome 5 at 114,105,840 bp
  • T to G, chromosome 5 at 121,205,839 bp
  • T to C, chromosome 6 at 12,320,970 bp
  • C to A, chromosome 6 at 15,196,977 bp
  • C to A, chromosome 6 at 85,620,253 bp
  • T to C, chromosome 6 at 140,528,597 bp
  • T to A, chromosome 7 at 30,720,735 bp
  • T to C, chromosome 7 at 45,444,649 bp
  • T to C, chromosome 7 at 80,329,543 bp
  • A to C, chromosome 7 at 108,668,045 bp
  • A to T, chromosome 8 at 16,233,051 bp
  • A to G, chromosome 8 at 109,895,502 bp
  • G to A, chromosome 9 at 7,465,620 bp
  • T to C, chromosome 9 at 95,500,684 bp
  • A to G, chromosome 9 at 104,324,218 bp
  • A to G, chromosome 9 at 106,075,356 bp
  • A to C, chromosome 9 at 110,767,929 bp
  • T to A, chromosome 10 at 70,961,158 bp
  • T to C, chromosome 11 at 46,342,452 bp
  • C to T, chromosome 11 at 61,250,948 bp
  • G to T, chromosome 13 at 24,436,685 bp
  • T to C, chromosome 13 at 100,423,083 bp
  • G to A, chromosome 14 at 34,086,071 bp
  • T to C, chromosome 15 at 60,823,576 bp
  • A to G, chromosome 15 at 89,165,331 bp
  • A to G, chromosome 15 at 97,680,536 bp
  • T to C, chromosome 17 at 25,372,554 bp
  • A to T, chromosome 17 at 63,941,326 bp
  • A to G, chromosome 18 at 65,624,784 bp
  • T to G, chromosome 19 at 4,215,788 bp
  • T to C, chromosome 19 at 43,753,199 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0095 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038381-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.