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Strain Name:
C57BL/6J-MtgxR0096Btlr/Mmmh
Stock Number:
038382-MU
Citation ID:
RRID:MMRRC_038382-MU
Other Names:
R0096 (G1), C57BL/6J-MtgxR0096Btlr
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Luc7l3
Name: LUC7-like 3 (S. cerevisiae)
Synonyms: 3300001P08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67684
Homologene: 75056
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: 2410141F18Rik, Jmjd2c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76804
Homologene: 41004
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: RBBP1L1, SAP180, BRCAA1, Rbp1l1, 6720480E17Rik, 6330417L24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, D030063F01Rik, C920006C10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Wdr59
Name: WD repeat domain 59
Synonyms: 5430401O09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319481
Homologene: 38685
Epb41l5
Name: erythrocyte membrane protein band 4.1 like 5
Synonyms: NBL5, 1700030C16Rik, E230025E14Rik, Lulu1, Epb4.1l5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226352
Homologene: 32492
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 71,053,730 bp
  • T to A, chromosome 1 at 119,623,911 bp
  • C to T, chromosome 1 at 170,312,034 bp
  • T to C, chromosome 1 at 170,329,247 bp
  • G to A, chromosome 2 at 10,251,378 bp
  • G to A, chromosome 2 at 18,889,039 bp
  • A to T, chromosome 2 at 89,156,296 bp
  • A to T, chromosome 2 at 120,502,529 bp
  • A to G, chromosome 2 at 121,301,505 bp
  • T to A, chromosome 2 at 150,472,300 bp
  • C to T, chromosome 2 at 163,087,536 bp
  • A to T, chromosome 2 at 169,021,109 bp
  • G to T, chromosome 2 at 178,403,735 bp
  • A to T, chromosome 3 at 72,928,267 bp
  • A to C, chromosome 3 at 97,767,467 bp
  • A to G, chromosome 4 at 74,357,343 bp
  • A to T, chromosome 4 at 113,597,768 bp
  • A to T, chromosome 5 at 62,843,040 bp
  • G to A, chromosome 5 at 89,701,717 bp
  • A to C, chromosome 6 at 48,931,188 bp
  • T to A, chromosome 6 at 127,732,627 bp
  • T to C, chromosome 6 at 132,115,606 bp
  • T to C, chromosome 7 at 3,497,551 bp
  • T to A, chromosome 7 at 10,580,058 bp
  • T to A, chromosome 7 at 82,465,699 bp
  • A to G, chromosome 7 at 87,037,319 bp
  • T to A, chromosome 7 at 105,638,230 bp
  • C to T, chromosome 7 at 127,489,487 bp
  • A to T, chromosome 8 at 105,708,931 bp
  • T to C, chromosome 8 at 111,504,373 bp
  • G to A, chromosome 8 at 122,485,370 bp
  • A to T, chromosome 9 at 3,758,928 bp
  • G to T, chromosome 9 at 9,009,313 bp
  • T to G, chromosome 9 at 35,611,834 bp
  • A to T, chromosome 9 at 38,539,536 bp
  • A to G, chromosome 9 at 65,273,670 bp
  • A to G, chromosome 9 at 103,222,159 bp
  • A to G, chromosome 10 at 24,050,254 bp
  • T to A, chromosome 10 at 78,748,705 bp
  • T to C, chromosome 10 at 90,074,062 bp
  • A to T, chromosome 11 at 30,114,739 bp
  • A to T, chromosome 11 at 58,386,757 bp
  • A to G, chromosome 11 at 79,038,247 bp
  • A to G, chromosome 11 at 80,484,332 bp
  • A to G, chromosome 11 at 94,301,494 bp
  • A to T, chromosome 11 at 100,706,471 bp
  • A to G, chromosome 11 at 113,903,144 bp
  • A to C, chromosome 11 at 114,754,332 bp
  • T to C, chromosome 12 at 55,739,505 bp
  • A to T, chromosome 12 at 70,191,166 bp
  • A to T, chromosome 12 at 100,838,651 bp
  • T to C, chromosome 13 at 14,129,194 bp
  • T to C, chromosome 13 at 24,805,940 bp
  • T to A, chromosome 13 at 32,886,283 bp
  • T to G, chromosome 13 at 97,931,254 bp
  • A to T, chromosome 14 at 47,064,297 bp
  • A to G, chromosome 15 at 65,855,441 bp
  • T to A, chromosome 15 at 90,499,915 bp
  • T to A, chromosome 15 at 98,893,988 bp
  • T to A, chromosome 16 at 14,204,367 bp
  • T to C, chromosome 16 at 88,034,226 bp
  • A to G, chromosome 17 at 20,227,479 bp
  • A to G, chromosome 17 at 24,895,669 bp
  • T to A, chromosome 17 at 67,805,413 bp
  • T to G, chromosome 18 at 22,921,858 bp
  • T to C, chromosome 18 at 58,598,757 bp
  • A to G, chromosome 19 at 8,778,517 bp
  • A to G, chromosome 19 at 29,631,388 bp
  • CCAGCAGCAGCAGCAGCA to CCAGCAGCAGCAGCA, chromosome X at 151,344,345 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0096 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038382-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.