Strain Name:
C57BL/6J-MtgxR0100Btlr/Mmmh
Stock Number:
038386-MU
Citation ID:
RRID:MMRRC_038386-MU
Other Names:
R0100 (G1), C57BL/6J-MtgxR0100Btlr
Major Collection:

Gene Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: Hrs, tn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235323
VEGA: 9
Homologene: 10840
Agrn
Name: agrin
Synonyms: Agrin, NMF380, nmf380
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, 6620402G01Rik, 9430077C05Rik, Etl-4, Skt, E330027G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 208618
Homologene: 10477
Ddx55
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
Synonyms: 2810021H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67848
Homologene: 12196
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18572
VEGA: 19
Homologene: 74968
Hip1
Name: huntingtin interacting protein 1
Synonyms: A930014B11Rik, HIP-1, 2610109B09Rik, E130315I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Gpatch2
Name: G patch domain containing 2
Synonyms: Gpatc2, 5830436K05Rik, 5830433G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67769
Homologene: 9976
Fam81a
Name: family with sequence similarity 81, member A
Synonyms: 6430514L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76886
Homologene: 17584
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 4921513O20Rik, D630001M17Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66725
Homologene: 18982
Cpxm2
Name: carboxypeptidase X 2 (M14 family)
Synonyms: 4632435C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 55987
Homologene: 69259
Il17b
Name: interleukin 17B
Synonyms: 1110006O16Rik, 1700006N07Rik, Zcyto7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 56069
VEGA: 18
HGNC: HGNC:5982
Homologene: 8689
H13
Name: histocompatibility 13
Synonyms: 4930443L17Rik, H-13, 1200006O09Rik, 5031424B04Rik, Spp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14950
Homologene: 7749
Dbr1
Name: debranching RNA lariats 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83703
Homologene: 9428
Dpp9
Name: dipeptidylpeptidase 9
Synonyms: DPRP2, 6430584G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224897
VEGA: 17
Homologene: 16385
Thoc6
Name: THO complex 6
Synonyms: Wdr58, F830014G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 386612
Homologene: 11533
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208263
Homologene: 9208
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223593
VEGA: 15
Homologene: 8898
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: B230373P09Rik, E030034C22Rik, Dnahc1, MDHC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22068
VEGA: 9
Homologene: 37944
Pram1
Name: PML-RAR alpha-regulated adaptor molecule 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 378460
Homologene: 12963
Atp6v0a4
Name: ATPase, H+ transporting, lysosomal V0 subunit A4
Synonyms: V-ATPase alpha 4, Atp6n1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 140494
HGNC: HGNC:866
Homologene: 39904
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106794
VEGA: 17
Homologene: 56267
4931406P16Rik
Name: RIKEN cDNA 4931406P16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233103
Homologene: 8795
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329628
Homologene: 14377
Plekhs1
Name: pleckstrin homology domain containing, family S member 1
Synonyms: 9930023K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226245
VEGA: 19
Homologene: 11770
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217944
VEGA: 12
Homologene: 56563
Gabrb2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
Synonyms: C030002O17Rik, C030021G16Rik, Gabrb-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Mocs3
Name: molybdenum cofactor synthesis 3
Synonyms: Uba4, 1700020H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69372
Homologene: 6108
Olfr1105
Name: olfactory receptor 1105
Synonyms: MOR172-7, GA_x6K02T2Q125-48521031-48520093, MOR0-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258085
Homologene: 121541
Fbxo47
Name: F-box protein 47
Synonyms: LOC380724, 2900052P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72973
Homologene: 47677
Gtf2ird2
Name: GTF2I repeat domain containing 2
Synonyms: 1700012P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 114674
Homologene: 24941
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 268527
Homologene: 8780
Atp13a4
Name: ATPase type 13A4
Synonyms: 9330174J19Rik, 4631413J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224079
Homologene: 75330
Osgepl1
Name: O-sialoglycoprotein endopeptidase-like 1
Synonyms: MGC13061, 2610001M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72085
Homologene: 5561
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240753
Homologene: 135779
Olfr346
Name: olfactory receptor 346
Synonyms: MOR136-11, GA_x6K02T2NLDC-33382467-33383396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258940
Homologene: 133616
Olfr1225
Name: olfactory receptor 1225
Synonyms: MOR233-11, GA_x6K02T2Q125-50650037-50649102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258893
Homologene: 17427
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 64899
Homologene: 84844
Spint5
Name: serine protease inhibitor, Kunitz type 5
Synonyms: Gm14316
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 641368
Homologene: 86198
Tnfrsf18
Name: tumor necrosis factor receptor superfamily, member 18
Synonyms: Gitr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21936
Homologene: 48270
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Nup210
Name: nucleoporin 210
Synonyms: gp210, gp190, Pom210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54563
Homologene: 41286
Olfr1344
Name: olfactory receptor 1344
Synonyms: MOR124-1, GA_x6K02T2QGBW-3169916-3170881, 4930415J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 257882
Mindy2
Name: MINDY lysine 48 deubiquitinase 2
Synonyms: Fam63b, B230380D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235461
VEGA: 9
Homologene: 101023
Ccdc51
Name: coiled-coil domain containing 51
Synonyms: 5730568A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66658
Homologene: 11646
Tmem106a
Name: transmembrane protein 106A
Synonyms: 0610008L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217203
Homologene: 16996
Bbof1
Name: basal body orientation factor 1
Synonyms: Ccdc176, 2900006K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 72873
Homologene: 75215
Tex22
Name: testis expressed gene 22
Synonyms: Tep22, 1700028O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 75671
Homologene: 84861
Trav7-6
Name: T cell receptor alpha variable 7-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 213480
Ift140
Name: intraflagellar transport 140
Synonyms: Tce5, Wdtc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106633
Homologene: 40979
Olfr121
Name: olfactory receptor 121
Synonyms: MOR263-4, GA_x6K02T2PSCP-2211113-2212078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258622
Homologene: 17195
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,323,213 bp
  • T to C, chromosome 1 at 133,270,177 bp
  • A to T, chromosome 1 at 156,007,075 bp
  • C to A, chromosome 1 at 187,225,817 bp
  • T to C, chromosome 2 at 20,339,905 bp
  • A to T, chromosome 2 at 36,688,911 bp
  • T to C, chromosome 2 at 87,033,595 bp
  • T to A, chromosome 2 at 89,171,087 bp
  • T to A, chromosome 2 at 152,689,863 bp
  • T to C, chromosome 2 at 160,905,340 bp
  • T to A, chromosome 2 at 164,717,000 bp
  • C to T, chromosome 2 at 168,231,190 bp
  • A to C, chromosome 3 at 38,980,248 bp
  • A to G, chromosome 4 at 156,028,366 bp
  • A to G, chromosome 4 at 156,174,958 bp
  • C to T, chromosome 5 at 124,556,782 bp
  • T to C, chromosome 5 at 134,217,015 bp
  • T to C, chromosome 5 at 135,436,453 bp
  • T to C, chromosome 6 at 38,076,815 bp
  • T to C, chromosome 6 at 48,908,604 bp
  • T to G, chromosome 6 at 91,069,193 bp
  • C to T, chromosome 7 at 6,440,400 bp
  • A to G, chromosome 7 at 34,254,011 bp
  • T to A, chromosome 7 at 132,054,871 bp
  • C to T, chromosome 9 at 8,653,034 bp
  • C to A, chromosome 9 at 49,035,932 bp
  • C to T, chromosome 9 at 70,102,809 bp
  • C to A, chromosome 9 at 70,607,449 bp
  • T to A, chromosome 9 at 99,583,669 bp
  • C to T, chromosome 9 at 109,091,998 bp
  • A to G, chromosome 11 at 42,487,314 bp
  • C to T, chromosome 11 at 97,868,606 bp
  • T to C, chromosome 11 at 101,586,258 bp
  • T to G, chromosome 11 at 120,482,852 bp
  • T to A, chromosome 12 at 16,680,224 bp
  • T to A, chromosome 12 at 84,411,055 bp
  • T to A, chromosome 12 at 113,088,772 bp
  • C to T, chromosome 12 at 117,721,299 bp
  • C to T, chromosome 14 at 31,262,152 bp
  • T to C, chromosome 14 at 53,717,072 bp
  • A to G, chromosome 15 at 59,344,098 bp
  • A to T, chromosome 15 at 91,745,796 bp
  • T to C, chromosome 16 at 29,421,724 bp
  • A to T, chromosome 17 at 23,669,850 bp
  • C to T, chromosome 17 at 25,090,954 bp
  • T to A, chromosome 17 at 33,641,399 bp
  • T to C, chromosome 17 at 37,752,703 bp
  • C to T, chromosome 17 at 56,205,854 bp
  • T to C, chromosome 17 at 80,275,156 bp
  • A to G, chromosome 18 at 61,690,271 bp
  • T to C, chromosome 19 at 47,102,666 bp
  • A to G, chromosome 19 at 56,478,502 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0100 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038386-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.