Strain Name:
C57BL/6J-MtgxR0111Btlr/Mmmh
Stock Number:
038397-MU
Citation ID:
RRID:MMRRC_038397-MU
Other Names:
R0111 (G1), C57BL/6J-MtgxR0111Btlr
Major Collection:

Gene Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Pde1b
Name: phosphodiesterase 1B, Ca2+-calmodulin dependent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18574
VEGA: 15
HGNC: HGNC:8775
Homologene: 37370
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104831
Homologene: 135706
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225432
VEGA: 18
Homologene: 35410
Rufy3
Name: RUN and FYVE domain containing 3
Synonyms: 2810428M05Rik, 6330416M07Rik, D5Bwg0860e, Rpipx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52822
Homologene: 87809
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74206
Homologene: 77938
Pitpna
Name: phosphatidylinositol transfer protein, alpha
Synonyms: Pitp alpha, Pitpn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18738
HGNC: HGNC:9001
Homologene: 55958
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226432
Homologene: 5874
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668303
Homologene: 18970
Calcr
Name: calcitonin receptor
Synonyms: Clr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12311
HGNC: HGNC:1440
Homologene: 1320
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117146
Homologene: 13775
Zfp953
Name: zinc finger protein 953
Synonyms: E130120F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 629016
Shld2
Name: shieldin complex subunit 2
Synonyms: 3110001K24Rik, Fam35a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75698
VEGA: 14
Homologene: 56840
Nefm
Name: neurofilament, medium polypeptide
Synonyms: NF160, Nfm, NF-M, NF165, Nef3, neurofilament-M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18040
HGNC: HGNC:7734
Homologene: 137211
Ostm1
Name: osteopetrosis associated transmembrane protein 1
Synonyms: gl, 1200002H13Rik, HSPC019
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14628
Homologene: 32203
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Spryd3
Name: SPRY domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223918
Homologene: 13138
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Clec4d
Name: C-type lectin domain family 4, member d
Synonyms: mMCL, Mpcl, Clecsf8, mcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17474
Homologene: 7844
Septin5
Name: septin 5
Synonyms: Cdcrel1, Pnutl1, Sept5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 18951
VEGA: 16
HGNC: HGNC:9164
Homologene: 74446
Nos3
Name: nitric oxide synthase 3, endothelial cell
Synonyms: eNOS, ecNOS, Nos-3, 2310065A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18127
HGNC: HGNC:7876
Homologene: 504
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, Ptpri, PTPL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627537
Homologene: 129750
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Vmn2r15
Name: vomeronasal 2, receptor 15
Synonyms: EG211223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 211223
Homologene: 129606
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190-B, p190B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Pold2
Name: polymerase (DNA directed), delta 2, regulatory subunit
Synonyms: p50, po1D2, 50kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18972
HGNC: HGNC:9176
Homologene: 4538
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: EGF-TM7, D17Ertd479e, FIRE, Gpr127, Emr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Zfp595
Name: zinc finger protein 595
Synonyms: A230042K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218314
Homologene: 120258
Ccl20
Name: chemokine (C-C motif) ligand 20
Synonyms: MIP-3[a], ST38, MIP-3A, MIP3A, Scya20, CKb4, exodus-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20297
Homologene: 3375
Espnl
Name: espin-like
Synonyms: LOC227357
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227357
Homologene: 77795
Slc30a10
Name: solute carrier family 30, member 10
Synonyms: E130106K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226781
VEGA: 1
Homologene: 100946
Usp20
Name: ubiquitin specific peptidase 20
Synonyms: 1700055M05Rik, Vdu2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74270
Homologene: 4861
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: 4930431B09Rik, Fam46c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74645
Homologene: 56783
Olfr70
Name: olfactory receptor 70
Synonyms: mOR6, MOR262-10, GA_x6K02T2N78B-16239704-16240654
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56014
Homologene: 10459
Rab42
Name: RAB42, member RAS oncogene family
Synonyms: 9530096D07Rik, Rab42-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242681
Homologene: 85237
Themis2
Name: thymocyte selection associated family member 2
Synonyms: ICB-1, BC013712
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230787
Homologene: 21009
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Hoxa2
Name: homeobox A2
Synonyms: Hox-1.11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15399
HGNC: HGNC:5103
Homologene: 4901
Cracr2a
Name: calcium release activated channel regulator 2A
Synonyms: LOC381812, LOC243645, Efcab4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381812
Homologene: 41883
Tas2r110
Name: taste receptor, type 2, member 110
Synonyms: T2R10, Tas2r10, STC 9-1, mt2r57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387344
Homologene: 130069
Vsig10l
Name: V-set and immunoglobulin domain containing 10 like
Synonyms: 2210412E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75690
Homologene: 35386
Prss36
Name: protease, serine 36
Synonyms: polyserase-2, C330007D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77613
Homologene: 18303
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212326
Homologene: 27540
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Pb99, A030001G24Rik, Gpr97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54672
Homologene: 18129
Kiss1r
Name: KISS1 receptor
Synonyms: Gpr54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 114229
VEGA: 10
HGNC: HGNC:4510
Homologene: 11411
Thap2
Name: THAP domain containing, apoptosis associated protein 2
Synonyms: 2900040O07Rik, 9030625G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66816
VEGA: 10
Homologene: 12039
Olfr804
Name: olfactory receptor 804
Synonyms: GA_x6K02T2PULF-11383575-11384519, MOR110-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258068
Homologene: 133581
Ifi47
Name: interferon gamma inducible protein 47
Synonyms: 47kDa, IRG-47, Iigp4, Igrd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15953
Homologene: 49169
Ppp3cc
Name: protein phosphatase 3, catalytic subunit, gamma isoform
Synonyms: PP2BA gamma, Calnc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19057
VEGA: 14
HGNC: HGNC:9316
Homologene: 68475
Asic1
Name: acid-sensing (proton-gated) ion channel 1
Synonyms: BNaC2, ASIC, ASIC1a, ASICalpha, ASIC1 beta, B530003N02Rik, Accn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11419
VEGA: 15
HGNC: HGNC:100
Homologene: 121755
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106618
Homologene: 27066
Cdh2
Name: cadherin 2
Synonyms: N-cadherin, Ncad, N-CAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,344,760 bp
  • T to C, chromosome 1 at 53,468,684 bp
  • A to G, chromosome 1 at 83,118,086 bp
  • A to T, chromosome 1 at 84,759,133 bp
  • T to C, chromosome 1 at 91,344,742 bp
  • A to G, chromosome 1 at 135,405,924 bp
  • C to A, chromosome 1 at 185,455,547 bp
  • T to A, chromosome 2 at 31,002,612 bp
  • A to T, chromosome 2 at 67,508,378 bp
  • A to C, chromosome 2 at 181,237,802 bp
  • T to C, chromosome 3 at 98,138,761 bp
  • T to C, chromosome 3 at 100,472,786 bp
  • T to C, chromosome 4 at 43,696,648 bp
  • T to C, chromosome 4 at 132,302,365 bp
  • C to A, chromosome 4 at 132,789,925 bp
  • C to T, chromosome 5 at 24,372,704 bp
  • C to T, chromosome 5 at 88,630,584 bp
  • T to C, chromosome 5 at 103,580,763 bp
  • T to C, chromosome 5 at 109,287,156 bp
  • T to A, chromosome 5 at 114,390,376 bp
  • C to T, chromosome 6 at 3,374,946 bp
  • T to A, chromosome 6 at 3,717,157 bp
  • T to C, chromosome 6 at 29,454,340 bp
  • T to G, chromosome 6 at 52,164,487 bp
  • C to A, chromosome 6 at 123,268,047 bp
  • A to G, chromosome 6 at 127,604,061 bp
  • T to C, chromosome 6 at 132,868,203 bp
  • G to A, chromosome 7 at 29,348,318 bp
  • A to G, chromosome 7 at 43,468,101 bp
  • A to T, chromosome 7 at 109,934,754 bp
  • A to G, chromosome 7 at 127,934,545 bp
  • C to T, chromosome 8 at 45,341,146 bp
  • T to C, chromosome 8 at 95,035,110 bp
  • A to G, chromosome 9 at 55,602,790 bp
  • T to C, chromosome 9 at 110,385,623 bp
  • T to C, chromosome 10 at 42,679,258 bp
  • T to A, chromosome 10 at 74,626,819 bp
  • A to G, chromosome 10 at 79,918,689 bp
  • T to C, chromosome 10 at 115,372,627 bp
  • T to A, chromosome 10 at 129,705,277 bp
  • A to G, chromosome 11 at 5,876,760 bp
  • T to A, chromosome 11 at 49,096,070 bp
  • T to C, chromosome 11 at 75,625,484 bp
  • T to C, chromosome 12 at 52,559,960 bp
  • T to C, chromosome 12 at 112,163,337 bp
  • A to G, chromosome 13 at 67,320,920 bp
  • T to A, chromosome 13 at 67,343,075 bp
  • T to C, chromosome 14 at 34,267,729 bp
  • T to C, chromosome 14 at 68,124,542 bp
  • C to T, chromosome 14 at 70,256,359 bp
  • G to T, chromosome 15 at 76,178,646 bp
  • T to C, chromosome 15 at 99,696,983 bp
  • A to T, chromosome 15 at 102,128,537 bp
  • T to C, chromosome 15 at 103,503,513 bp
  • A to T, chromosome 16 at 18,624,469 bp
  • A to T, chromosome 16 at 34,031,590 bp
  • C to A, chromosome 17 at 19,522,120 bp
  • A to G, chromosome 17 at 25,848,444 bp
  • A to T, chromosome 17 at 55,817,073 bp
  • A to T, chromosome 17 at 67,737,498 bp
  • A to T, chromosome 18 at 16,774,509 bp
  • T to A, chromosome 18 at 42,305,672 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0111 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038397-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.