Strain Name:
C57BL/6J-MtgxR0137Btlr/Mmmh
Stock Number:
038422-MU
Citation ID:
RRID:MMRRC_038422-MU
Other Names:
R0137 (G1), C57BL/6J-MtgxR0137Btlr
Major Collection:

Gene Information

Gene Symbol: Npr1 [MGI:97371] (Mus musculus (mouse))
Name: natriuretic peptide receptor 1
Synonyms: NPRA, GC-A, guanylyl cyclase-A, NPR-A
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Slc17a6 [MGI:2156052] (Mus musculus (mouse))
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: VGLUT2, 2900073D12Rik
Chromosome: 7
Alteration at locus: Chemically Induced
Gene Symbol: Hpcal1 [MGI:1855689] (Mus musculus (mouse))
Name: hippocalcin-like 1
Synonyms: visinin like 3, neural visinin-like 3, Vnsl3, VILIP3, Nvp3
Chromosome: 12
Alteration at locus: Chemically Induced
Gene Symbol: Prkdc [MGI:104779] (Mus musculus (mouse))
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PK, slip, DOXNPH, XRCC7, DNA-PKcs, dxnph
Chromosome: 16
Alteration at locus: Chemically Induced
Gene Symbol: Plekha1 [MGI:2442213] (Mus musculus (mouse))
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Synonyms: C920009D07Rik, TAPP1
Chromosome: 7
Alteration at locus: Chemically Induced
Gene Symbol: Gart [MGI:95654] (Mus musculus (mouse))
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Gaps, Prgs
Chromosome: 16
Alteration at locus: Chemically Induced
Gene Symbol: Scg3 [MGI:103032] (Mus musculus (mouse))
Name: secretogranin III
Synonyms: SgIII, Chgd, 1B1075
Chromosome: 9
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 38,019,243 bp
  • T to C, chromosome 1 at 52,645,429 bp
  • C to T, chromosome 1 at 74,679,692 bp
  • T to C, chromosome 1 at 91,262,254 bp
  • T to A, chromosome 2 at 31,672,485 bp
  • G to A, chromosome 2 at 31,908,616 bp
  • T to C, chromosome 2 at 35,692,376 bp
  • T to C, chromosome 2 at 91,494,982 bp
  • C to T, chromosome 2 at 91,625,730 bp
  • C to A, chromosome 2 at 93,199,351 bp
  • C to G, chromosome 2 at 156,912,225 bp
  • G to A, chromosome 3 at 76,707,479 bp
  • C to T, chromosome 3 at 90,455,937 bp
  • T to A, chromosome 4 at 76,136,903 bp
  • G to T, chromosome 4 at 92,147,200 bp
  • T to A, chromosome 4 at 119,393,548 bp
  • T to A, chromosome 4 at 132,232,108 bp
  • T to C, chromosome 4 at 135,751,006 bp
  • T to C, chromosome 4 at 148,470,624 bp
  • T to C, chromosome 5 at 6,770,534 bp
  • T to A, chromosome 5 at 26,035,984 bp
  • C to T, chromosome 5 at 49,963,840 bp
  • G to A, chromosome 5 at 87,778,967 bp
  • T to C, chromosome 5 at 91,957,599 bp
  • A to G, chromosome 5 at 115,332,201 bp
  • A to T, chromosome 5 at 122,800,632 bp
  • A to T, chromosome 5 at 134,559,460 bp
  • T to C, chromosome 5 at 135,366,633 bp
  • A to G, chromosome 5 at 139,293,221 bp
  • T to A, chromosome 6 at 27,762,390 bp
  • A to G, chromosome 6 at 41,462,561 bp
  • C to A, chromosome 6 at 88,297,649 bp
  • A to T, chromosome 6 at 126,533,383 bp
  • G to A, chromosome 6 at 127,080,165 bp
  • C to T, chromosome 6 at 129,732,208 bp
  • A to T, chromosome 7 at 4,124,720 bp
  • T to C, chromosome 7 at 18,614,633 bp
  • A to G, chromosome 7 at 24,105,733 bp
  • A to T, chromosome 7 at 34,239,219 bp
  • T to C, chromosome 7 at 35,287,242 bp
  • T to C, chromosome 7 at 45,897,662 bp
  • A to C, chromosome 7 at 51,666,144 bp
  • A to G, chromosome 7 at 80,320,578 bp
  • A to G, chromosome 7 at 104,003,502 bp
  • T to A, chromosome 7 at 127,611,686 bp
  • C to T, chromosome 7 at 130,897,446 bp
  • A to G, chromosome 8 at 22,243,039 bp
  • A to T, chromosome 8 at 83,724,898 bp
  • A to T, chromosome 8 at 119,442,480 bp
  • A to T, chromosome 8 at 120,151,376 bp
  • C to A, chromosome 9 at 20,878,387 bp
  • A to T, chromosome 9 at 21,142,130 bp
  • A to G, chromosome 9 at 31,066,710 bp
  • A to T, chromosome 9 at 37,425,344 bp
  • C to A, chromosome 9 at 65,510,328 bp
  • A to T, chromosome 9 at 75,663,180 bp
  • G to C, chromosome 9 at 82,927,191 bp
  • A to G, chromosome 9 at 109,091,630 bp
  • A to T, chromosome 9 at 110,485,038 bp
  • T to C, chromosome 10 at 4,546,950 bp
  • G to A, chromosome 10 at 53,563,430 bp
  • C to A, chromosome 10 at 76,596,425 bp
  • T to A, chromosome 11 at 6,228,148 bp
  • T to C, chromosome 11 at 29,222,431 bp
  • A to G, chromosome 11 at 100,563,568 bp
  • A to G, chromosome 11 at 100,696,997 bp
  • A to T, chromosome 11 at 102,868,617 bp
  • A to C, chromosome 12 at 17,786,388 bp
  • A to G, chromosome 13 at 21,142,166 bp
  • A to C, chromosome 13 at 23,232,804 bp
  • A to T, chromosome 13 at 46,764,603 bp
  • T to A, chromosome 14 at 20,987,015 bp
  • G to A, chromosome 14 at 123,840,686 bp
  • A to T, chromosome 15 at 9,062,987 bp
  • G to T, chromosome 15 at 35,926,219 bp
  • T to C, chromosome 15 at 76,334,781 bp
  • G to T, chromosome 15 at 85,821,567 bp
  • G to C, chromosome 15 at 99,322,738 bp
  • A to T, chromosome 15 at 103,481,964 bp
  • T to C, chromosome 16 at 15,740,332 bp
  • T to C, chromosome 16 at 21,504,386 bp
  • T to A, chromosome 16 at 36,951,174 bp
  • A to G, chromosome 16 at 45,980,526 bp
  • T to A, chromosome 16 at 91,625,394 bp
  • A to G, chromosome 18 at 14,655,143 bp
  • G to T, chromosome 18 at 37,891,849 bp
  • G to A, chromosome 18 at 68,313,700 bp
  • A to G, chromosome 19 at 8,740,857 bp
  • G to A, chromosome 19 at 10,979,333 bp
  • T to C, chromosome 19 at 29,809,697 bp
  • A to C, chromosome 19 at 40,915,866 bp
  • T to C, chromosome 19 at 41,873,850 bp
  • A to T, chromosome 19 at 44,534,382 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0137 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038422-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.