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Strain Name:
C57BL/6J-MtgxR0208Btlr/Mmmh
Stock Number:
038461-MU
Citation ID:
RRID:MMRRC_038461-MU
Other Names:
R0208 (G1), C57BL/6J-MtgxR0208Btlr
Major Collection:

Strain Information

D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Gsr
Name: glutathione reductase
Synonyms: Gr-1, Gr1, D8Ertd238e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14782
HGNC: HGNC:4623
Homologene: 531
Pkp4
Name: plakophilin 4
Synonyms: p0071, Armrp, 5031422I09Rik, 9430019K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, SBP2, 2810012K13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Arfgef2
Name: ARF guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Cdk7
Name: cyclin dependent kinase 7
Synonyms: CRK4 PK (CDC2-related-kinase-4 protein kinase), Crk4, Cdkn7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12572
VEGA: 13
HGNC: HGNC:1778
Homologene: 1363
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: P112, S1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Gcfc2
Name: GC-rich sequence DNA binding factor 2
Synonyms: AW146020
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330361
HGNC: HGNC:1317
Homologene: 2411
Polr1d
Name: polymerase (RNA) I polypeptide D
Synonyms: mRPA16, 16kDa, 1110003G10Rik, Rpo1-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20018
Homologene: 22239
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Il2ra
Name: interleukin 2 receptor, alpha chain
Synonyms: IL-2R alpha chain, CD25, Ly-43, Il2r
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16184
HGNC: HGNC:6008
Homologene: 360
Hepacam2
Name: HEPACAM family member 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101202
Homologene: 18724
Hrct1
Name: histidine rich carboxyl terminus 1
Synonyms: 3830408D24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039781
Eng
Name: endoglin
Synonyms: CD105, Endo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13805
HGNC: HGNC:3349
Homologene: 92
Pcdhb18
Name: protocadherin beta 18
Synonyms: Pcdhb9, PcdhbR
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93889
Homologene: 137649
Spint1
Name: serine protease inhibitor, Kunitz type 1
Synonyms: HAI-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20732
Homologene: 9653
Nptxr
Name: neuronal pentraxin receptor
Synonyms: NPR, 1700036C17Rik, 5730406O18Rik, D15Bwg0580e, NPCD
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73340
HGNC: HGNC:7954
Homologene: 8620
Muc19
Name: mucin 19
Synonyms: apomucin, sld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239611
Ackr4
Name: atypical chemokine receptor 4
Synonyms: VSHK1, CCR11, CCBP2, PPR1, CCX-CKR, A630091E18Rik, Ccrl1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Usf3
Name: upstream transcription factor family member 3
Synonyms: LOC207806, LOC385650, 5530400K22Rik, Gm608
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207806
Homologene: 19504
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320495
Homologene: 32271
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG620718, EG667069
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: PBP, Moca
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 442801
Homologene: 18345
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: GA_x6K02T2RE5P-3430689-3429787, MOR202-24, EG667271, Olfr1458
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Arhgef5
Name: Rho guanine nucleotide exchange factor 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54324
Homologene: 66300
Clstn3
Name: calsyntenin 3
Synonyms: Cst-3, CSTN3, alcadein-beta, Clstn3b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232370
Homologene: 22836
Grik3
Name: glutamate receptor, ionotropic, kainate 3
Synonyms: Glur-7, Glur7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14807
HGNC: HGNC:4581
Homologene: 73901
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Aadacl2fm1
Name: AADACL2 family member 1
Synonyms: C130079G13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229333
Asb2
Name: ankyrin repeat and SOCS box-containing 2
Synonyms: 1110008E15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 65256
Homologene: 69202
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Mybphl
Name: myosin binding protein H-like
Synonyms: 1110037P11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68753
Homologene: 19221
Sec16b
Name: SEC16 homolog B, endoplasmic reticulum export factor
Synonyms: Rgpr-p117, Rgpr, Lztr2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 89867
Homologene: 13227
Scgb2b27
Name: secretoglobin, family 2B, member 27
Synonyms: C2a, Abpb, Scgb2b5, Abpbg5, Abpbg27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233099
Homologene: 83171
Klk1b9
Name: kallikrein 1-related peptidase b9
Synonyms: mGk-9, Egfbp-3, Egfbp3, Klk9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13648
Homologene: 68141
Slc28a1
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
Synonyms: Cnt1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434203
Homologene: 37902
Krtap9-3
Name: keratin associated protein 9-3
Synonyms: 2310040M23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75586
Homologene: 137392
Pgbd1
Name: piggyBac transposable element derived 1
Synonyms: 4921509E05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319207
Homologene: 130030
Cenpj
Name: centromere protein J
Synonyms: 4932437H03Rik, Sas4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219103
Homologene: 10204
H2-M10.4
Name: histocompatibility 2, M region locus 10.4
Synonyms: 15H
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224753
Homologene: 117973
Pold4
Name: polymerase (DNA-directed), delta 4
Synonyms: DNA polymerase delta smallest subunit p12, p12, 2410012M21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69745
VEGA: 19
Homologene: 10909
Or8h9
Name: olfactory receptor family 8 subfamily H member 9
Synonyms: GA_x6K02T2Q125-48446067-48445129, MOR206-3, Olfr1099
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258764
Homologene: 107003
Atp8a1
Name: ATPase phospholipid transporting 8A1
Synonyms: Atp3a2, B230107D19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11980
Homologene: 48402
Tada3
Name: transcriptional adaptor 3
Synonyms: ADA3, 1110004B19Rik, Tada3l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101206
Homologene: 4633
Rasip1
Name: Ras interacting protein 1
Synonyms: 2610025P08Rik, Rain
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69903
Homologene: 9847
Or5p73
Name: olfactory receptor family 5 subfamily P member 73
Synonyms: GA_x6K02T2PBJ9-10795522-10796514, MOR204-36, Olfr498
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258304
Homologene: 133600
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Zmat4
Name: zinc finger, matrin type 4
Synonyms: 9630048M01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320158
Homologene: 81899
Sgsm2
Name: small G protein signaling modulator 2
Synonyms: D630003G22Rik, Rutbc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 97761
Homologene: 14780
Serpinb6c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6c
Synonyms: SPIC, ovalbumin, Spi3C
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97848
HGNC: HGNC:8950
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,285,144 bp
  • T to C, chromosome 1 at 86,133,741 bp
  • G to C, chromosome 1 at 136,281,000 bp
  • G to T, chromosome 1 at 157,552,935 bp
  • A to G, chromosome 1 at 174,192,960 bp
  • A to C, chromosome 1 at 188,531,761 bp
  • T to C, chromosome 2 at 11,682,017 bp
  • A to G, chromosome 2 at 24,607,480 bp
  • A to T, chromosome 2 at 32,678,993 bp
  • A to G, chromosome 2 at 59,266,436 bp
  • G to T, chromosome 2 at 86,959,404 bp
  • T to C, chromosome 2 at 119,248,345 bp
  • C to T, chromosome 2 at 122,055,696 bp
  • C to T, chromosome 2 at 166,867,422 bp
  • C to T, chromosome 3 at 59,932,689 bp
  • T to C, chromosome 3 at 64,539,912 bp
  • T to C, chromosome 3 at 108,375,415 bp
  • C to T, chromosome 4 at 43,549,151 bp
  • C to A, chromosome 4 at 43,727,384 bp
  • T to C, chromosome 4 at 103,208,154 bp
  • C to T, chromosome 4 at 121,052,288 bp
  • T to A, chromosome 4 at 125,686,165 bp
  • C to A, chromosome 4 at 148,464,975 bp
  • A to T, chromosome 5 at 67,774,721 bp
  • T to A, chromosome 5 at 108,681,752 bp
  • A to C, chromosome 5 at 147,078,680 bp
  • A to T, chromosome 6 at 3,467,505 bp
  • A to G, chromosome 6 at 38,139,450 bp
  • A to G, chromosome 6 at 43,273,341 bp
  • A to T, chromosome 6 at 81,943,463 bp
  • A to T, chromosome 6 at 113,367,007 bp
  • A to G, chromosome 6 at 124,432,169 bp
  • C to A, chromosome 7 at 34,012,137 bp
  • T to A, chromosome 7 at 43,979,430 bp
  • C to A, chromosome 7 at 45,632,575 bp
  • A to T, chromosome 7 at 81,117,706 bp
  • A to G, chromosome 7 at 108,465,543 bp
  • A to G, chromosome 7 at 114,497,981 bp
  • T to A, chromosome 8 at 23,902,067 bp
  • T to A, chromosome 8 at 33,689,355 bp
  • A to G, chromosome 9 at 104,099,661 bp
  • G to T, chromosome 9 at 106,996,996 bp
  • A to G, chromosome 10 at 6,920,062 bp
  • A to T, chromosome 11 at 68,946,373 bp
  • A to G, chromosome 11 at 74,868,241 bp
  • A to G, chromosome 11 at 86,300,856 bp
  • A to G, chromosome 11 at 98,155,689 bp
  • C to A, chromosome 11 at 99,597,837 bp
  • G to A, chromosome 12 at 103,092,027 bp
  • T to A, chromosome 12 at 103,325,271 bp
  • A to C, chromosome 12 at 118,043,774 bp
  • A to C, chromosome 13 at 21,434,481 bp
  • G to A, chromosome 13 at 33,897,396 bp
  • A to G, chromosome 13 at 51,679,845 bp
  • G to T, chromosome 13 at 100,706,514 bp
  • G to T, chromosome 14 at 56,563,970 bp
  • T to C, chromosome 15 at 74,586,807 bp
  • A to T, chromosome 15 at 79,789,715 bp
  • A to G, chromosome 15 at 91,893,024 bp
  • C to A, chromosome 16 at 44,216,906 bp
  • A to G, chromosome 17 at 36,460,483 bp
  • T to C, chromosome 18 at 37,490,187 bp
  • T to A, chromosome 18 at 77,404,866 bp
  • T to G, chromosome 19 at 4,232,539 bp
  • G to A, chromosome 19 at 13,103,278 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0208 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038461-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.